Gịnị bụ Hydroxypropyl Methylcellulose (HPMC)?

Hydroxypropyl Methylcellulose (HPMC)bụ cellulose ether nke na-abụghị ionic nke e ji ihe polymer eke mee - owu a nụchara anụcha ma ọ bụ pulp osisi site na ọgwụgwọ alkali na usoro mgbanwe mmeghachi omume kemịkalụ. HPMC nwere ezigbo mgbaze, nkwụsi ike okpomọkụ na ihe ndị na-emepụta ihe nkiri. Ọ bụ ihe dị mkpa maka kemịkalụ nwere ọtụtụ ojiji. A na-ejikarị ya eme ihe n'iwu ụlọ, ọgwụ, nri, ihe ịchọ mma na ngalaba ndị ọzọ.

1. Nhazi kemịkalụ na ihe ndị bụ isi

Isi ihe dị na HPMC bụ na ụfọdụ otu hydroxyl dị na molekul cellulose ka ejiri methyl (–CH₃) na hydroxypropyl (–CH₂CHOHCH₃) dochie, si otú a na-emepụta cellulose ether agbanwere agbanwe. N'ihi ịdị n'otu nke otu hydrophilic na hydrophobic na nhazi molekul ya, ọ nwere ọrụ elu na ihe ndị na-emepụta fim dị mma.

HPMC bụ ntụ ntụ ọcha ma ọ bụ granule na-acha ọcha ma ọ bụ nke na-acha ọcha, ọ naghị esi isi ma na-enweghị ụtọ, a pụkwara ịgbaze ya na mmiri oyi iji mepụta mmiri colloidal doro anya ma ọ bụ nke na-agbaze ntakịrị. Ọ naghị agbaze na mmiri ọkụ, ethanol, chloroform na ether, mana ọ na-agbaze na ụfọdụ ihe mgbaze organic agwakọtara (dịka methanol/mmiri, ethanol/mmiri agwakọtara).

Njirimara anụ ahụ nke HPMC gụnyere

Njupụta doro anya: ihe dị ka 0.3 ~ 0.5 g/cm³;

nkwụsi ike nke pH: pH nke mmiri mmiri kwụsiri ike n'etiti 3 ~ 11;

Thermogelation: Ngwọta HPMC nwere ihe ndị na-eme ka okpomọkụ dị. Mgbe a na-ekpo ọkụ ya ruo n'okpomọkụ ụfọdụ, ọ ga-agbanwe usoro iji mepụta jel, wee laghachi n'ọnọdụ ngwọta ahụ mgbe ọ jụrụ oyi;

Ọrụ elu: O nwere ezigbo emulsification, mgbasa na ihe ndị na-ejide mmiri;

Ike imebi ihe: Ebe ọ bụ na ọ bụ ihe sitere n'okike ma ọ naghị egbu egbu, ọ na-adịghị emerụ gburugburu ebe obibi ma na-emebi ihe.

2. Usoro mmepụta

A na-ejikarị cellulose eke eme HPMC site na usoro usoro ndị a:

Mmeghachi omume alkaline: Jiri owu ma ọ bụ mkpụrụ osisi a nụchara anụcha mee ihe n'okpuru ọnọdụ alkaline iji mebie usoro cellulose molekul ma mee ka ọrụ mmeghachi omume dịkwuo elu;

Mmeghachi omume nke mmetọ: Meghachi omume na methyl chloride na propylene oxide n'okpuru ọnọdụ okpomọkụ na nrụgide kwesịrị ekwesị iji webata otu methyl na hydroxypropyl;

Nkwụsị, ịsa na ịkpọ nkụ: Wepụ ihe ndị na-adịghị na ihe ndị na-adịghị na ya, ma kpọọ ha nkụ ka ha bụrụ ngwaahịa emechara emechaa;

Ịkpọcha na inyocha ihe: Ghichaa ihe kpọrọ nkụ ahụ n'ime nha ihe achọrọ ma tinye ya n'ime akpa.

3. Ebe ndị bụ isi e ji eme ihe

3.1. Ụlọ ọrụ ihe owuwu

A na-ejikarị HPMC eme ihe n'ọtụtụ ebe n'ụlọ ọrụ ihe owuwu, a na-ejikarị ya eme ihe n'ime ngwa agha akọrọ, ihe nrapado taịlị, ngwaahịa gypsum, ngwa agha mkpuchi okpomọkụ, ala nhazi onwe ya na ngwaahịa ndị ọzọ, yana ọrụ ndị a:

Mmiri siri ike iji gbochie mmiri ịla n'iyi tupu oge eruo;

Mee ka njikọta dịkwuo mma ma melite arụmọrụ owuwu;

Meziwanye arụmọrụ owuwu na arụmọrụ mgbochi sag;

Jikwaa oge ntọala na mmiri nke simenti.

3.2. Ụlọ ọrụ ọgwụ

A na-eji HPMC eme ihe dị ka ihe mkpuchi kapsụl, ihe na-arapara mbadamba, ihe na-adịgide adịgide, ihe na-eme ka ihe dị nro, wdg. na nkwadebe ọgwụ. Ọ bụ ihe a na-ejikarị eme ọgwụ nwere njirimara ndị a:

Ọ naghị egbu egbu, ọ naghị ewe iwe, a pụkwara ịṅụ ya n'ọnụ;

Ezigbo ihe onwunwe nke na-emepụta ihe nkiri, nke enwere ike iji chịkwaa ọnụego mwepụta nke ọgwụ;

Enwere ike iji ya dị ka ihe eji emepụta kapsụl ndị anaghị eri anụ iji dochie gelatin;

Njirimara Thermogel dị mma maka mwepụta ọgwụ ndị na-ebelata okpomọkụ.

3.3. Ụlọ ọrụ nri

N'ihe gbasara nhazi nri, a na-ejikarị HPMC eme ihe dị ka emulsifier, thickener, stabilizer, gluu, wdg. Dịka ọmụmaatụ:

Dịka ihe na-ejide mmiri na ihe na-eme ka ihe ndị e ji eme achịcha ka mma;

Meziwanye uto na arụmọrụ nkwụsịtụ n'ihe ọṅụṅụ;

Dịka ihe na-ejide mmiri na ihe na-eme ka anụ ahụ ka mma;

A na-eji ya dochie mmanụ na abụba dị n'ime nri ndị nwere obere abụba iji nweta ihe ngosi uto.

3.4. Ihe ịchọ mma na ngwaahịa kemịkalụ kwa ụbọchị

A na-eji HPMC eme ihe n'ọtụtụ ebe n'ihe gbasara nlekọta akpụkpọ ahụ, ncha ntutu, ihe nhicha ezé, ihe nhicha ihu, wdg, ma na-arụ ọrụ ndị a:

Sistemụ emulsion na-eme ka ọ sie ike ma na-eme ka ọ sie ike;

Ime ka mgbasa ya dịkwuo mma ma melite ịdị ire ụtọ nke ngwaahịa;

Nhazi ihe nkiri na inye mmetụta mmiri mmiri;

Enwere ike iji ya kwadebe gels ma ọ bụ emulsions doro anya.

3.5. Ụlọ ọrụ ndị ọzọ

Ụlọ ọrụ mkpuchi: eji ya dị ka ihe na-eme ka ihe dị arọ ma na-agbasa ihe maka mkpuchi mmiri;

Ọrụ Ugbo: eji ya eme ihe dị ka ihe na-ebu ọgwụ ahụhụ na fatịlaịza iji wepụta ngwa ngwa;

Ụlọ ọrụ mbipụta akwụkwọ: eji ya dị ka ihe na-eme ka ihe na-eme ka ihe dị arọ maka ibipụta ink;

Seramiki na ihe owuwu ụlọ: eji ya dị ka ihe na-eme ka ọ dị nro ma na-eme ka ọ dị nro n'ime usoro ịkpụzi ihe.

4. Nchekwa na nchekwa gburugburu ebe obibi

A na-esi n'eriri osisi eke enweta HPMC, ọ na-enwekwa ezigbo nkwekọ na ire ere. Ọ naghị egbu egbu ma ọ dịghị emerụ ahụ mmadụ ahụ mgbe ejiri ya mee ihe n'ime oke ọnụọgụgụ kwesịrị ekwesị, ọ na-emezukwa ụkpụrụ nchekwa maka ihe mgbakwunye nri na ọgwụ. Ọ naghị emerụ gburugburu ebe obibi, enwere ike imebi ya n'okpuru ọnọdụ eke, ọ gaghịkwa ebute ibu arọ gburugburu ebe obibi.

Hydroxypropyl methylcellulose (HPMC), dịka cellulose ether nke nwere arụmọrụ dị mma na ojiji sara mbara, bụ ihe mgbakwunye dị mkpa maka ọtụtụ ọrụ na ụlọ ọrụ ọgbara ọhụrụ. Site na ezigbo ihe onwunwe anụ ahụ na kemịkalụ ya, nchekwa na nchekwa gburugburu ebe obibi, HPMC na-aga n'ihu na-arụ ọrụ dị mkpa n'ọtụtụ ubi. Site na mmepe nke kemistri akwụkwọ ndụ akwụkwọ ndụ na echiche mmepe na-adigide,ubi ngwa nke HPMC ga-anọgide na-agbasa, na atụmanya mmepe ya sara mbara.