Hydroxypropyl Methylcellulose (HPMC) bụ ihe dị mkpa e ji emepụta cellulose ether nke ejirila mee ihe n'ọtụtụ ebe n'ụlọ ọrụ mmepụta ihe n'ihi na ọ nwere ihe pụrụ iche na nke kemịkalụ. Ọdịdị ya bụ otu n'ime ihe ndị kacha mkpa HPMC nwere, na-emetụta arụmọrụ ya ozugbo n'ọtụtụ ngwa.
1. Njirimara bụ isi nke HPMC
HPMC bụ cellulose ether nke na-abụghị ionic nke e nwetara site na iji dochie akụkụ nke otu hydroxyl (–OH) dị na molekul cellulose site na iji otu methoxy (–OCH3) na otu hydroxypropyl (–OCH2CH(OH)CH3). O nwere ezigbo mgbaze na mmiri na ụfọdụ ihe mgbaze organic, na-emepụta ngwọta colloidal doro anya. A na-ekpebi oke viscosity nke HPMC site na ibu molekul ya, ogo nnọchi (DS, Ogo Mgbanwe) na nkesa nnọchi.
2. Nchọpụta nke viscosity nke HPMC
A na-ejikarị ihe na-atụgharị agbagharị ma ọ bụ ihe na-eme ka ihe dị n'ime mmiri tụọ oke mmiri nke ngwọta HPMC. Mgbe a na-atụ ya, a ga-eleba anya na ntinye, okpomọkụ na ọnụego nsị nke ngwọta ahụ, n'ihi na ihe ndị a nwere ike imetụta uru viscosity nke ngwọta ahụ nke ukwuu.
Njupụta nke ngwọta: Njupụta nke HPMC na-abawanye ka mmụba nke njupụta nke ngwọta ahụ si dị ala. Mgbe njupụta nke ngwọta HPMC dị ala, mmekọrịta dị n'etiti molekul na-adị ike ma njupụta ahụ na-adị ala. Ka njupụta ahụ na-abawanye, njupụta na mmekọrịta dị n'etiti molekul na-abawanye, na-eme ka mmụba dị ukwuu na njupụta ahụ sikwuo ike.
Okpomọkụ: Ọbara mmiri nke ngwọta HPMC na-enwe mmetụta dị ukwuu na okpomọkụ. N'ozuzu, ka okpomọkụ na-abawanye, ọbara mmiri nke ngwọta HPMC ga-ebelata. Nke a bụ n'ihi mmụba okpomọkụ nke na-eduga na mmụba nke mmegharị molekul na mmekọrịta intermolecular na-adịghị ike. Ọ dị mkpa ịmara na HPMC nwere ọkwa dị iche iche nke nnọchi na ibu molekul nwere mmetụta dị iche iche na okpomọkụ.
Ọnụego ịkpụcha: Ngwọta HPMC na-egosipụta omume pseudoplastic (ịkpụcha akpụcha), ya bụ, viscosity dị elu na obere ọnụego ịkpụcha akpụcha ma na-ebelata na nnukwu ọnụego ịkpụcha akpụcha. Omume a bụ n'ihi ike ịkpụcha akpụcha nke na-ahazi agbụ molekul n'akụkụ ebe a na-akpụcha akpụcha, si otú a na-ebelata njikọ na mmekọrịta dị n'etiti molekul.
3. Ihe ndị na-emetụta viscosity HPMC
Ibu molekul: Ibu molekul nke HPMC bụ otu n'ime ihe ndị bụ isi na-ekpebi viscosity ya. N'ikwu ya n'ozuzu, ka ibu molekul buru ibu, otú ahụ ka viscosity nke ngwọta ahụ si dị elu. Nke a bụ n'ihi na molekul HPMC nwere ibu molekul dị elu nwere ike ịmepụta netwọk ndị kekọtara agwakọta, si otú a na-eme ka esemokwu dị n'ime nke ngwọta ahụ dịkwuo elu.
Ọkwa nke mgbanwe na nkesa ihe nnọchi anya: Ọnụọgụgụ na nkesa nke ihe nnọchi anya methoxy na hydroxypropyl na HPMC na-emetụtakwa viscosity ya. N'ozuzu, ka ọkwa mgbanwe methoxy (DS) dị elu, otú ahụ ka viscosity nke HPMC na-ebelata, n'ihi na ntinye nke ihe nnọchi anya methoxy ga-ebelata ike njikọ hydrogen n'etiti molekul. Ntinye nke ihe nnọchi anya hydroxypropyl ga-eme ka mmekọrịta dị n'etiti molekul dịkwuo elu, si otú a na-eme ka viscosity dịkwuo elu. Na mgbakwunye, nkesa otu nke ihe nnọchi anya na-enyere aka ịmepụta usoro ngwọta kwụsiri ike ma na-eme ka viscosity nke ngwọta dịkwuo elu.
Uru pH nke ngwọta ahụ: Ọ bụ ezie na HPMC bụ polima na-abụghị ionic na viscosity ya anaghị emetụta mgbanwe na uru pH nke ngwọta ahụ, oke pH (dị oke acidic ma ọ bụ alkaline) nwere ike ibute mmebi nke nhazi molekul nke HPMC, si otú a na-emetụta viscosity ahụ.
4. Ngwa ubi nke HPMC
N'ihi njirimara viscosity ya dị mma, a na-ejikarị HPMC eme ihe n'ọtụtụ ebe:
Ihe owuwu ụlọ: N'ihe owuwu ụlọ, a na-eji HPMC eme ihe dị ka ihe na-eme ka ihe sie ike ma na-ejide mmiri iji melite arụmọrụ owuwu ma mee ka mgbochi mgbawa dịkwuo elu.
Ụlọ ọrụ ọgwụ: N'ụlọ ọrụ ọgwụ, a na-eji HPMC eme ihe dị ka ihe na-ejikọ mbadamba, ihe na-emepụta ihe nkiri maka mkpụrụọgwụ na ihe na-ebu ọgwụ ndị na-adịgide adịgide.
Ụlọ ọrụ nri: A na-eji HPMC eme ihe dị ka ihe na-eme ka ihe sie ike ma na-eme ka ọ sie ike n'ụlọ ọrụ nri maka imepụta ice cream, jelii na ngwaahịa mmiri ara ehi.
Ngwaahịa kemịkalụ kwa ụbọchị: N'ime ngwaahịa kemịkalụ kwa ụbọchị, a na-eji HPMC eme ihe dị ka ihe na-eme ka ihe sie ike ma na-eme ka ọ sie ike maka imepụta shampoo, jel ịsa ahụ, ihe nhicha ezé, wdg.
Àgwà viscosity nke HPMC bụ ntọala maka arụmọrụ ya dị mma n'ọtụtụ ngwa. Site n'ịchịkwa ibu molekul, ogo nnọchi, na ọnọdụ ngwọta nke HPMC, enwere ike ịgbanwe viscosity ya ka ọ zute mkpa ngwa dị iche iche. N'ọdịnihu, nnyocha miri emi gbasara mmekọrịta dị n'etiti nhazi molekul HPMC na viscosity ga-enyere aka ịmepụta ngwaahịa HPMC nwere arụmọrụ ka mma ma gbasaa ubi ngwa ya.
Oge ozi: Julaị-20-2024