(1) Okwu Mmalite maka HPMC
Hydroxypropyl Methylcellulose (HPMC) bụ ihe dị mkpa nke na-abụghị nke ionic cellulose ether nke a na-ejikarị eme ihe nchacha, ihe owuwu ụlọ, nri, ọgwụ na ihe ndị ọzọ. N'ime ihe nchacha ákwà, a na-eji HPMC eme ihe dị ka ihe na-eme ka ọ sie ike ma na-agbaze nke ọma, na-eme ka nrapado na ịsa ákwà nke ọma. Agbanyeghị, iji nweta oke viscosity nke HPMC na ihe nchacha ákwà, a ga-atụle ọtụtụ ihe, gụnyere ụdị, dose, ọnọdụ mgbaze, usoro mgbakwunye, wdg. nke HPMC.
(2) Ihe ndị na-emetụta viscosity HPMC
1. Ụdị na ụdị nke HPMC
Ibu na oke nke mgbanwe molekul (methoxy na hydroxypropyl nnọchi) nke HPMC na-emetụta kpọmkwem viscosity na njirimara mmiri ya. Ụdị HPMC dị iche iche nwere oke viscosity dị iche iche. Ịhọrọ ụdị HPMC nke dabara na ihe achọrọ maka nhazi saịpụ ákwà gị dị mkpa. N'ozuzu, HPMC dị arọ molekul dị elu na-enye viscosity dị elu, ebe HPMC dị ala na-enye viscosity dị ala.
2. Ọnụọgụ nke HPMC
Ọnụọgụ HPMC na-enwe mmetụta dị ukwuu na viscosity. Dịka ọ na-adịkarị, a na-agbakwunye HPMC n'etiti 0.5% na 2% na ncha ákwà. Ọnụọgụ nke dị oke ala agaghị enweta mmetụta siri ike achọrọ, ebe ọnụọgụ nke dị oke elu nwere ike ibute nsogbu dịka nsogbu na mgbaze na ngwakọta na-adịghị mma. Ya mere, a ga-agbanwe usoro nke HPMC dịka mkpa ụfọdụ na nsonaazụ nnwale si dị iji nweta viscosity kacha mma.
3. Ọnọdụ mgbaze
Ọnọdụ mgbasa nke HPMC (okpomọkụ, uru pH, ọsọ mkpali, wdg) nwere mmetụta dị mkpa na viscosity ya:
Okpomọkụ: HPMC na-agbaze nwayọ nwayọ na obere okpomọkụ mana ọ nwere ike inye viscosity dị elu. Ọ na-agbaze ngwa ngwa na oke okpomọkụ mana ọ nwere obere viscosity. A na-atụ aro ka a gbazee HPMC n'etiti 20-40°C iji hụ na ọ kwụsiri ike ma nwee viscosity.
pH: HPMC na-arụ ọrụ nke ọma n'okpuru ọnọdụ na-anọpụ iche. Oke pH (oke acidic ma ọ bụ oke alkaline) nwere ike imebi nhazi nke HPMC ma belata viscosity ya. Ya mere, ijikwa uru pH nke sistemụ ịsa ákwà n'etiti 6-8 na-enyere aka ịnọgide na-enwe nkwụsi ike na viscosity nke HPMC.
Ọsọ ịkpalite: Ọsọ ịkpalite kwesịrị ekwesị nwere ike ime ka HPMC gbazee, mana oke ịkpalite nwere ike ibute afụfụ ma metụta otu ihe ngwọta ahụ. A na-atụkarị aro ka ejiri ọsọ nwayọ na nke na-akpali akpali gbazee HPMC kpamkpam.
4. Tinye iwu
HPMC na-emepụta agglomerates ngwa ngwa na mmiri, na-emetụta mgbasa ya na arụmọrụ viscosity ya. Ya mere, usoro e si etinye HPMC dị oke mkpa:
Ịgwakọta ya tupu oge eruo: Gwakọta HPMC na ntụ ntụ ndị ọzọ kpọrọ nkụ nke ọma wee jiri nwayọọ nwayọọ tinye ha na mmiri, nke nwere ike igbochi mkpụkọ ma nyere aka ịgbaze nke ọma.
Mmiri mmiri: Tupu ị tinye HPMC na mmiri ịsa ákwà, ị nwere ike ibu ụzọ tinye obere mmiri oyi n'ime ya, wee tinye mmiri ọkụ iji gbazee ya. Nke a nwere ike ime ka arụmọrụ ịgbaze na ịdị nro nke HPMC ka mma.
(3) Usoro iji melite viscosity HPMC
1. Nhazi usoro
Họrọ ụdị na ọnụọgụ HPMC kwesịrị ekwesị dabere na ojiji na ihe achọrọ maka ncha ákwà. Ncha ákwà nhicha dị elu nwere ike ịchọ oke viscosity HPMC, ebe ngwaahịa nhicha izugbe nwere ike ịhọrọ oke viscosity HPMC dị ọkara ruo obere.
2. Nnwale nnwale
Mee obere nnwale n'ime ụlọ nyocha iji hụ mmetụta ya na viscosity nke ihe nhicha ákwà site n'ịgbanwe ọnụọgụ, ọnọdụ nkesa, usoro mgbakwunye, wdg. nke HPMC. Dekọọ paramita na nsonaazụ nke nnwale ọ bụla iji chọpụta ngwakọta kacha mma.
3. Nhazi usoro
Tinye usoro nri na ọnọdụ nhazi kachasị mma nke ụlọ nyocha ahụ n'ahịrị mmepụta ma gbanwee ha maka mmepụta buru ibu. Hụ na HPMC na-ekesa ma na-agbaze otu otu n'oge usoro mmepụta iji zere nsogbu dịka mkpọmkpọ na ịgbaze na-adịghị mma.
4. Njikwa ịdị mma
Site na usoro nnwale mma, dịka nha viscometer, nyocha nha ihe, wdg, a na-enyocha arụmọrụ nke HPMC na ncha ákwà iji hụ na o ruru viscosity a tụrụ anya ya na mmetụta ojiji ya. Mee nyocha mma mgbe niile ma gbanwee usoro na usoro ozugbo ma ọ bụrụ na achọpụta nsogbu.
(4) Ajụjụ na azịza ndị a na-ajụkarị
1. Mgbasa nke HPMC adịghị mma
Ihe Ndị Mere Ya: Okpomọkụ na-adịghị mma nke na-agbasa, ọsọ na-akpali akpali nke ukwuu ma ọ bụ na-adịghị nwayọ, usoro mgbakwunye na-ekwesịghị ekwesị, wdg.
Ngwọta: Gbanwee okpomọkụ nke ịgbaze ruo 20-40°C, jiri ọsọ nwayọ na nke na-akpali akpali, ma mee ka usoro mgbakwunye ahụ ka mma.
2. viscosity HPMC adịghị mma
Ihe Ndị Mere: Ụdị HPMC adịghị mma, usoro onunu ogwu ezughi oke, uru pH dị oke elu ma ọ bụ dị ala, wdg.
Ngwọta: Họrọ ụdị na usoro HPMC kwesịrị ekwesị, ma chịkwaa uru pH nke sistemụ ịsa ákwà n'etiti 6-8.
3. Nhazi nke mkpokọta HPMC
Ihe kpatara ya: E tinyere HPMC ozugbo n'ime ngwọta ahụ, ọnọdụ mgbaze na-ezighi ezi, wdg.
Ngwọta: Jiri usoro tupu agwakọta ya, buru ụzọ gwakọta HPMC na ntụ ntụ ndị ọzọ kpọrọ nkụ, wee jiri nwayọ tinye ya na mmiri ka ọ gbazee.
Iji nweta oke ikuku nke HPMC na ihe eji asa ákwà, a ga-atụle ihe ndị dị ka ụdị, ọnụọgụ, ọnọdụ mgbaze, na usoro itinye HPMC. Site na nhazi usoro sayensị, nnwale nnwale na mgbanwe usoro, enwere ike ime ka arụmọrụ viscosity nke HPMC ka mma nke ọma, si otú a na-eme ka mmetụta ojiji na asọmpi ahịa nke ihe eji asa ákwà dịkwuo mma.
Oge ozi: Julaị-08-2024