(1) Kev Taw Qhia Txog HPMC
Hydroxypropyl Methylcellulose (HPMC) yog ib qho tseem ceeb nonionic cellulose ether siv dav hauv cov tshuaj ntxuav tes, cov ntaub ntawv tsim kho, khoom noj, tshuaj thiab lwm yam teb. Hauv cov tshuaj ntxuav khaub ncaws, HPMC yog siv los ua cov khoom ua kom tuab kom muab kev ruaj khov thiab solubility zoo heev, txhim kho qhov lo thiab ntxuav ntawm cov tshuaj ntxuav khaub ncaws. Txawm li cas los xij, txhawm rau kom ua tiav qhov viscosity zoo tshaj plaws ntawm HPMC hauv cov tshuaj ntxuav khaub ncaws, ntau yam yuav tsum tau xav txog, suav nrog hom, koob tshuaj, cov xwm txheej yaj, kev ntxiv, thiab lwm yam ntawm HPMC.
(2) Cov yam ntxwv uas cuam tshuam rau HPMC viscosity
1. Hom thiab qauv ntawm HPMC
Qhov hnyav molecular thiab qib ntawm kev hloov pauv (methoxy thiab hydroxypropyl hloov pauv) ntawm HPMC cuam tshuam ncaj qha rau nws cov viscosity thiab solubility cov yam ntxwv. Ntau hom HPMC muaj ntau yam viscosity sib txawv. Kev xaiv tus qauv HPMC uas haum rau koj cov kev xav tau ntawm cov tshuaj ntxhua khaub ncaws yog qhov tseem ceeb. Feem ntau hais lus, qhov hnyav molecular siab dua HPMCs muab viscosities siab dua, thaum qhov hnyav molecular qis dua HPMCs muab viscosities qis dua.
2. Kev siv tshuaj HPMC
Qhov ntau ntawm HPMC muaj qhov cuam tshuam loj rau qhov viscosity. Feem ntau, HPMC raug ntxiv rau hauv qhov ntau ntawm 0.5% thiab 2% hauv cov tshuaj ntxhua khaub ncaws. Qhov ntau tsawg dhau yuav tsis ua tiav qhov thickening effect xav tau, thaum qhov ntau dhau yuav ua rau muaj teeb meem xws li nyuaj rau yaj thiab sib tov tsis sib xws. Yog li ntawd, qhov ntau ntawm HPMC yuav tsum tau hloov kho raws li qhov xav tau tshwj xeeb thiab cov txiaj ntsig sim kom ua tiav qhov viscosity zoo tshaj plaws.
3. Cov xwm txheej yaj
Cov xwm txheej yaj ntawm HPMC (kub, pH tus nqi, kev sib xyaw ceev, thiab lwm yam) muaj qhov cuam tshuam tseem ceeb rau nws cov viscosity:
Kub: HPMC yaj qeeb dua ntawm qhov kub qis dua tab sis tuaj yeem muab cov viscosities siab dua. Yaj sai dua ntawm qhov kub siab tab sis muaj viscosity qis dua. Nws raug pom zoo kom yaj HPMC ntawm 20-40 ° C kom ntseeg tau tias nws ruaj khov thiab viscosity.
pH: HPMC ua tau zoo tshaj plaws nyob rau hauv cov xwm txheej nruab nrab. Cov nqi pH siab heev (acidic dhau los yog alkaline dhau) tuaj yeem rhuav tshem cov qauv ntawm HPMC thiab txo nws cov viscosity. Yog li ntawd, kev tswj hwm tus nqi pH ntawm cov tshuaj ntxhua khaub ncaws ntawm 6-8 pab tswj kev ruaj khov thiab viscosity ntawm HPMC.
Kev sib xyaw ceev: Kev sib xyaw ceev kom haum tuaj yeem ua rau HPMC yaj, tab sis kev sib xyaw ntau dhau yuav ua rau muaj npuas thiab cuam tshuam rau qhov sib xws ntawm cov tshuaj. Feem ntau nws raug pom zoo kom siv qhov kev sib xyaw qeeb thiab sib npaug kom yaj tag nrho HPMC.
4. Ntxiv qhov kev txiav txim
HPMC yooj yim tsim cov agglomerates hauv cov kua, cuam tshuam rau nws cov kev yaj thiab viscosity. Yog li ntawd, qhov kev txiav txim uas HPMC ntxiv yog qhov tseem ceeb:
Ua ntej sib tov: Sib tov HPMC nrog lwm cov hmoov qhuav sib npaug thiab tom qab ntawd maj mam ntxiv rau hauv dej, uas tuaj yeem tiv thaiv kev tsim cov pawg thiab pab kom yaj sib npaug.
Moisturizing: Ua ntej ntxiv HPMC rau hauv cov tshuaj ntxhua khaub ncaws, koj tuaj yeem ua ntej ntub nws nrog me ntsis dej txias, thiab tom qab ntawd ntxiv dej kub kom yaj nws. Qhov no tuaj yeem txhim kho qhov ua tau zoo ntawm kev yaj thiab viscosity ntawm HPMC.
(3) Cov kauj ruam los ua kom zoo dua HPMC viscosity
1. Tsim qauv mis
Xaiv tus qauv HPMC thiab cov koob tshuaj raws li kev siv kawg thiab qhov yuav tsum tau ua ntawm cov tshuaj ntxhua khaub ncaws. Cov tshuaj ntxhua khaub ncaws ua haujlwm tau zoo yuav xav tau HPMC viscosity siab, thaum cov khoom ntxuav dav dav yuav xaiv HPMC viscosity nruab nrab mus rau qis.
2. Kev sim ua ntej
Ua cov kev sim me me hauv chav kuaj mob kom pom nws qhov cuam tshuam rau qhov viscosity ntawm cov tshuaj ntxhua khaub ncaws los ntawm kev hloov pauv qhov ntau npaum li cas, cov xwm txheej yaj, kev txiav txim ntxiv, thiab lwm yam ntawm HPMC. Sau cov kev ntsuas thiab cov txiaj ntsig ntawm txhua qhov kev sim kom txiav txim siab qhov sib xyaw ua ke zoo tshaj plaws.
3. Kev hloov kho txheej txheem
Siv cov zaub mov txawv zoo tshaj plaws hauv chav kuaj thiab cov txheej txheem rau cov kab ntau lawm thiab kho lawv rau kev tsim khoom loj. Xyuas kom meej tias kev faib tawm thiab kev yaj ntawm HPMC sib npaug thaum lub sijhawm tsim khoom kom tsis txhob muaj teeb meem xws li cov pawg thiab kev yaj tsis zoo.
4. Kev tswj xyuas zoo
Los ntawm cov txheej txheem kuaj xyuas zoo, xws li kev ntsuas viscometer, kev tshuaj xyuas qhov loj me ntawm cov khoom me me, thiab lwm yam, kev ua haujlwm ntawm HPMC hauv cov tshuaj ntxhua khaub ncaws raug saib xyuas kom ntseeg tau tias nws ua tiav qhov viscosity thiab siv tau zoo. Ua qhov kev tshuaj xyuas zoo tsis tu ncua thiab kho cov txheej txheem thiab cov mis sai sai yog tias pom muaj teeb meem.
(4) Cov lus nug thiab cov kev daws teeb meem uas nug ntau zaus
1. Kev yaj tsis zoo ntawm HPMC
Vim li cas: Qhov kub yaj tsis tsim nyog, qhov ceev do sai dhau los yog qeeb dhau, qhov kev txiav txim ntxiv tsis raug, thiab lwm yam.
Kev daws teeb meem: Kho qhov kub ntawm kev yaj mus rau 20-40 ° C, siv qhov ceev qeeb thiab sib npaug, thiab ua kom zoo dua qhov kev sib ntxiv.
2. HPMC viscosity tsis yog txog li tus qauv
Vim li cas: Tus qauv HPMC tsis tsim nyog, qhov ntau npaum li cas tsis txaus, tus nqi pH siab dhau lossis qis dhau, thiab lwm yam.
Kev daws teeb meem: Xaiv cov qauv HPMC thiab cov koob tshuaj uas tsim nyog, thiab tswj tus nqi pH ntawm cov tshuaj ntxhua khaub ncaws ntawm 6-8.
3. Kev tsim cov pawg HPMC
Vim li cas: HPMC tau ntxiv ncaj qha rau hauv cov tshuaj, cov xwm txheej tsis zoo ntawm kev yaj, thiab lwm yam.
Kev daws teeb meem: Siv txoj kev ua ntej sib tov, ua ntej sib tov HPMC nrog lwm cov hmoov qhuav, thiab maj mam ntxiv rau hauv dej kom yaj.
Yuav kom ua tiav qhov viscosity zoo tshaj plaws ntawm HPMC hauv cov tshuaj ntxhua khaub ncaws, cov yam xws li hom, koob tshuaj, cov xwm txheej yaj, thiab kev txiav txim ntawm kev ntxiv HPMC yuav tsum tau txiav txim siab tag nrho. Los ntawm kev tsim cov mis tshuaj, kev sim sim thiab kev hloov kho cov txheej txheem, qhov kev ua tau zoo ntawm viscosity ntawm HPMC tuaj yeem ua kom zoo dua, yog li txhim kho cov txiaj ntsig siv thiab kev sib tw ua lag luam ntawm cov tshuaj ntxhua khaub ncaws.
Lub sijhawm tshaj tawm: Lub Xya Hli-08-2024