Hydroxypropyl methylcellulose (HPMC), ua ib qho cellulose derivative, feem ntau siv rau hauv kev tsim kho, tshuaj, khoom noj, tshuaj txhua hnub thiab lwm yam lag luam. Qhov zoo ntawm HPMC feem ntau yog txiav txim siab los ntawm cov yam ntxwv ntawm lub cev thiab tshuaj lom neeg, kev ua haujlwm zoo thiab kev siv cov txiaj ntsig.
1. Qhov tsos thiab xim
HPMC feem ntau yog hmoov dawb lossis dawb tawm lossis granules. Yog tias muaj kev hloov pauv xim tseem ceeb, xws li daj, greying, thiab lwm yam, nws txhais tau tias nws qhov huv tsis siab lossis nws muaj kuab paug. Tsis tas li ntawd, qhov sib npaug ntawm qhov loj me ntawm cov khoom me me kuj qhia txog qib kev tswj hwm ntawm cov txheej txheem ntau lawm. Cov khoom me me zoo HPMC yuav tsum tau faib sib npaug yam tsis muaj kev sib sau ua ke lossis cov khoom tsis huv.
2. Kev sim tshuaj yaj
HPMC muaj cov dej solubility zoo, uas yog ib qho cim qhia tseem ceeb rau kev txiav txim siab nws qhov zoo. Los ntawm kev sim yooj yim, nws cov solubility thiab viscosity tuaj yeem soj ntsuam. Cov kauj ruam yog raws li nram no:
Siv me me ntawm HPMC hmoov, maj mam ntxiv rau hauv dej txias lossis dej kub hauv chav tsev, thiab saib nws cov txheej txheem yaj. HPMC zoo yuav tsum tau sib npaug zos hauv lub sijhawm luv luv yam tsis muaj cov dej nag pom tseeb, thiab thaum kawg tsim cov kua colloidal pob tshab lossis me ntsis turbid.
Qhov nrawm ntawm kev yaj ntawm HPMC muaj feem cuam tshuam nrog nws cov qauv molecular, qib ntawm kev hloov pauv, thiab cov txheej txheem purity. Cov HPMC tsis zoo yuav yaj qeeb thiab yooj yim tsim cov ntshav txhaws uas nyuaj rau decompose.
3. Kev ntsuas viscosity
Viscosity yog ib qho ntawm cov yam tseem ceeb tshaj plaws rau HPMC zoo. Nws cov viscosity hauv dej yog cuam tshuam los ntawm qhov hnyav molecular thiab qib ntawm kev hloov pauv, thiab feem ntau ntsuas los ntawm lub rotational viscometer lossis capillary viscometer. Txoj kev tshwj xeeb yog yaj ib qho nyiaj ntawm HPMC hauv dej, npaj cov tshuaj ntawm qee qhov concentration, thiab tom qab ntawd ntsuas qhov viscosity ntawm cov tshuaj. Raws li cov ntaub ntawv viscosity, nws tuaj yeem txiav txim siab tias:
Yog tias tus nqi viscosity qis dhau, nws txhais tau tias qhov hnyav molecular me me lossis nws tau raug puas tsuaj thaum lub sijhawm tsim khoom;
Yog tias tus nqi viscosity siab dhau, nws txhais tau tias qhov hnyav molecular loj dhau lossis qhov hloov pauv tsis sib xws.
4. Kev kuaj pom qhov huv
Qhov huv ntawm HPMC yuav cuam tshuam ncaj qha rau nws qhov kev ua tau zoo. Cov khoom uas muaj qhov huv qis feem ntau muaj ntau cov seem lossis cov khoom tsis huv. Kev txiav txim siab ua ntej tuaj yeem ua los ntawm cov txheej txheem yooj yim hauv qab no:
Kev sim cov khoom seem thaum hlawv: Muab me me ntawm HPMC qauv rau hauv lub cub tawg kub thiab hlawv nws. Qhov ntau ntawm cov khoom seem tuaj yeem cuam tshuam cov ntsiab lus ntawm cov ntsev inorganic thiab cov hlau ions. Cov khoom seem HPMC zoo yuav tsum me me heev.
Kev ntsuas tus nqi pH: Siv HPMC kom tsim nyog thiab yaj rau hauv dej, thiab siv daim ntawv kuaj pH lossis lub ntsuas pH los ntsuas tus nqi pH ntawm cov tshuaj. Hauv qab qhov xwm txheej ib txwm muaj, HPMC cov tshuaj aqueous yuav tsum ze rau qhov nruab nrab. Yog tias nws yog acidic lossis alkaline, tej zaum yuav muaj cov khoom tsis huv lossis cov khoom seem.
5. Cov khoom siv thermal thiab thermal stability
Los ntawm kev ua kom sov cov qauv HPMC, nws qhov kev ruaj khov thermal tuaj yeem pom. HPMC zoo yuav tsum muaj kev ruaj khov thermal siab thaum lub sijhawm ua kom sov thiab yuav tsum tsis txhob lwj lossis ua tsis tiav sai. Cov kauj ruam yooj yim ntawm kev sim ua haujlwm thermal suav nrog:
Ua kom sov me me ntawm cov qauv rau ntawm lub phaj kub thiab saib nws qhov melting point thiab decomposition kub.
Yog tias cov qauv pib lwj lossis hloov xim ntawm qhov kub qis dua, nws txhais tau tias nws qhov kev ruaj khov thermal tsis zoo.
6. Kev txiav txim siab txog cov dej noo
Cov dej noo ntau dhau ntawm HPMC yuav cuam tshuam rau nws qhov kev ruaj khov thiab kev ua tau zoo ntawm kev khaws cia. Nws cov dej noo tuaj yeem txiav txim siab los ntawm txoj kev hnyav:
Muab cov qauv HPMC tso rau hauv qhov cub thiab ziab ntawm 105 ℃ kom txog qhov hnyav tas li, tom qab ntawd xam qhov sib txawv ntawm qhov hnyav ua ntej thiab tom qab ziab kom tau txais cov dej noo. HPMC zoo yuav tsum muaj cov dej noo tsawg, feem ntau tswj tau qis dua 5%.
7. Qib ntawm kev hloov pauv nrhiav tau
Qhov degree ntawm kev hloov pauv ntawm methoxy thiab hydroxypropoxy pawg ntawm HPMC cuam tshuam ncaj qha rau nws cov kev ua tau zoo, xws li solubility, gel kub, viscosity, thiab lwm yam. Qhov degree ntawm kev hloov pauv tuaj yeem txiav txim siab los ntawm kev titration tshuaj lossis infrared spectroscopy, tab sis cov txheej txheem no nyuaj dua thiab yuav tsum tau ua hauv chav kuaj mob. Hauv ntej, HPMC nrog kev hloov pauv qis muaj solubility tsis zoo thiab tuaj yeem tsim cov gels tsis sib xws hauv dej.
8. Kev ntsuas kub ntawm Gel
Qhov kub ntawm HPMC yog qhov kub uas nws tsim cov gel thaum lub sijhawm cua sov. HPMC zoo muaj qhov kub tshwj xeeb ntawm gel, feem ntau ntawm 60 ° C thiab 90 ° C. Txoj kev sim rau qhov kub ntawm gel yog:
Yaj HPMC hauv dej, maj mam nce qhov kub, thiab saib qhov kub uas cov tshuaj hloov pauv los ntawm pob tshab mus rau turbid, uas yog qhov kub ntawm gel. Yog tias qhov kub ntawm gel txawv ntawm qhov ib txwm muaj, nws txhais tau tias nws cov qauv molecular lossis qib kev hloov pauv tsis ua raws li tus qauv.
9. Kev ntsuam xyuas kev ua tau zoo
Qhov kev ua tau zoo ntawm daim ntawv thov HPMC rau ntau lub hom phiaj yuav txawv. Piv txwv li, hauv kev lag luam kev tsim kho, HPMC feem ntau siv ua tus neeg sawv cev khaws dej thiab ua kom tuab. Nws cov kev ua tau zoo khaws dej thiab cov nyhuv tuab tuaj yeem sim los ntawm kev sim mortar lossis putty. Hauv kev lag luam tshuaj thiab khoom noj, HPMC yog siv ua cov khoom siv zaj duab xis lossis cov khoom siv capsule, thiab nws cov nyhuv tsim zaj duab xis thiab cov khoom colloidal tuaj yeem sim los ntawm kev sim.
10. Cov ntxhiab tsw thiab cov khoom uas yaj tau yooj yim
HPMC zoo yuav tsum tsis muaj ntxhiab tsw qab. Yog tias cov qauv muaj ntxhiab tsw qab lossis saj txawv teb chaws, nws txhais tau tias cov tshuaj tsis xav tau tau nkag mus rau hauv nws cov txheej txheem ntau lawm lossis nws muaj cov tshuaj uas hloov pauv tau yooj yim. Tsis tas li ntawd, HPMC zoo yuav tsum tsis txhob tsim cov pa roj uas ua rau khaus ntawm qhov kub siab.
Qhov zoo ntawm HPMC tuaj yeem txiav txim siab los ntawm kev sim lub cev yooj yim xws li kev ntsuas qhov tsos, kev yaj thiab viscosity, lossis los ntawm cov tshuaj lom neeg xws li kev sim purity thiab kev sim thermal. Los ntawm cov txheej txheem no, kev txiav txim siab ua ntej tuaj yeem ua rau qhov zoo ntawm HPMC, yog li ua kom nws ruaj khov hauv kev siv tiag tiag.
Lub sijhawm tshaj tawm: Cuaj hlis-25-2024