IHydroxypropyl Methylcellulose (HPMC)iyi-polymer encibilika emanzini evame ukusetshenziswa ezimbonini zemithi, zokudla, izimonyo, nezokwakha. Umswakamo we-HPMC udlala indima ebalulekile ekucutshungulweni kwayo nasekuzinzeni. Kuthinta izakhiwo ze-rheological, ukuncibilika, nempilo yeshalofu yezinto ezibonakalayo. Ukuqonda okuqukethwe komswakama kubalulekile ekwakhiweni kwawo, ekugcinweni kwawo, nasekusetshenzisweni kwawo ekugcineni.
Okuqukethwe Umswakama kwe-HPMC
Umswakama we-AnxinCel®HPMC ngokuvamile unqunywa izimo zenqubo kanye nebanga elithile le-polymer esetshenzisiwe. Umswakamo ungahluka kuye ngezinto ezingavuthiwe, izimo zokuwugcina, kanye nenqubo yokomisa. Ngokuvamile kuvezwa njengephesenti lesisindo sesampula ngaphambi nangemuva kokumiswa. Ezisetshenziswa ezimbonini, umswakama obalulekile ubalulekile, njengoba umswakama owedlulele ungaholela ekulimaleni, ekuqoqweni, noma ekwehliseni ukusebenza kwe-HPMC.
Umswakamo we-HPMC ungasukela ku-5% ukuya ku-12%, nakuba ububanzi obujwayelekile buphakathi kuka-7% no-10%. Umswakamo unganqunywa ngokomisa isampula ezingeni lokushisa elithile (isb., 105°C) uze ufinyelele isisindo esingaguquki. Umehluko ngesisindo ngaphambi nangemuva kokoma umele umswakama.
Izinto Ezithinta Okuqukethwe Komswakama ku-HPMC
Izinto ezimbalwa zingaba nomthelela ekujuleni komswakama we-HPMC:
Umswakamo Nezimo Zokugcina:
Umswakama ophezulu noma izimo ezingafanele zokugcina zingakhuphula umswakama we-HPMC.
I-HPMC i-hygroscopic, okusho ukuthi ijwayele ukumunca umswakama emoyeni ozungezile.
Ukupakishwa nokuvala umkhiqizo kunganciphisa ukumuncwa komswakama.
Izimo Zokucubungula:
Izinga lokushisa lokumisa nesikhathi ngesikhathi sokukhiqiza kungaba nomthelela ekugcineni umswakama.
Ukomisa ngokushesha kungabangela umswakama osele, kuyilapho ukomisa kancane kungase kubangele umswakama owengeziwe ukuba ugcinwe.
Ibanga le-HPMC:
Amabanga ahlukene e-HPMC (isb, i-viscosity ephansi, i-viscosity emaphakathi, noma i-viscosity ephezulu) angase abe nokuqukethwe komswakamo okuhluka kancane ngenxa yomehluko wesakhiwo samangqamuzana nokucutshungulwa.
Imininingwane Yomhlinzeki:
Abahlinzeki bangase banikeze i-HPMC okuqukethwe komswakama okucacisiwe okuhambisana nezindinganiso zezimboni.
Okuqukethwe Okujwayelekile Kokuswakama kwe-HPMC ngokweBanga
Umswakama we-HPMC uyahlukahluka kuye ngebanga kanye nokusetshenziswa okuhlosiwe. Nali ithebula elibonisa amazinga omswakama ajwayelekile wamabanga ahlukene e-HPMC.
| Ibanga le-HPMC | I-Viscosity (cP) | Okuqukethwe Umswakama (%) | Izinhlelo zokusebenza |
| I-HPMC ye-Viscosity ephansi | 5 – 50 | 7 – 10 | Imithi (amaphilisi, amaphilisi), izimonyo |
| I-Medium Viscosity HPMC | 100 - 400 | 8 – 10 | Imithi (ukukhululwa okulawulwayo), ukudla, okunamathelayo |
| High Viscosity HPMC | 500 - 2000 | 8 – 12 | Ukwakhiwa (okusekelwe kusimende), ukudla (i-ejenti yokuqina) |
| I-HPMC yezemithi | 100 - 4000 | 7-9 | Amathebulethi, i-capsule coatings, ukwakheka kwejeli |
| Ukudla-Ibanga HPMC | 50 - 500 | 7 – 10 | Ukuqina kokudla, i-emulsification, i-coatings |
| Ibanga Lokwakha i-HPMC | 400 - 10000 | 8 – 12 | Udaka, ama-adhesives, ama-plaster, izingxube ezomile |
Ukuhlola kanye Nokunqunywa Kokuqukethwe Komswakama
Kunezindlela ezimbalwa ezijwayelekile zokunquma okuqukethwe komswakama we-HPMC. Izindlela ezimbili ezivame kakhulu yilezi:
Indlela yeGravimetric (Ukulahlekelwa Ekomisweni, LOD):
Lena indlela esetshenziswa kakhulu yokunquma okuqukethwe komswakama. Isisindo esaziwayo se-HPMC sifakwa kuhhavini wokomisa obekwe ku-105°C. Ngemva kwesikhathi esibekiwe (imvamisa amahora angu-2-4), isampula liyakalwa futhi. Umehluko ngesisindo unikeza okuqukethwe komswakama, okuvezwa njengephesenti lesisindo sesampula sokuqala.
I-Karl Fischer Titration:
Le ndlela inembe kakhulu kune-LOD futhi ibandakanya ukusabela kwamakhemikhali okulinganisa okuqukethwe kwamanzi. Le ndlela ivame ukusetshenziswa lapho kudingeka ukunqunywa okunembile komswakama.
Umthelela Wokuqukethwe Komswakama Ezimpahleni ze-HPMC
Umswakamo we-AnxinCel®HPMC unomthelela ekusebenzeni kwayo ezinhlelweni ezahlukene:
I-Viscosity:Okuqukethwe umswakama kungathinta i-viscosity yezixazululo ze-HPMC. Umswakama ophezulu ungakhuphula i-viscosity ekwakhekeni okuthile, kuyilapho umswakama ophansi ungase uholele ekubonakaleni okuphansi.
Ukunyibilika:Umswakama oweqile ungaholela ekuhlanganisweni noma ekuncipheni kokuncibilika kwe-HPMC emanzini, kuyenze ingasebenzi kahle kwezinye izinhlelo zokusebenza, njengokwakheka okulawulwayo okukhishwayo embonini yezemithi.
Ukuzinza:I-HPMC ngokuvamile izinzile ezimeni ezomile, kodwa umswakama ophezulu ungaholela ekukhuleni kwamagciwane noma ukuwohloka kwamakhemikhali. Ngalesi sizathu, i-HPMC ivamise ukugcinwa ezitsheni ezivaliwe ezindaweni ezinomswakama ophansi.
Okuqukethwe Umswakama kanye Nokupakishwa kwe-HPMC
Ngenxa yemvelo ye-hygroscopic ye-HPMC, ukupakishwa okufanele kubalulekile ukuze kuvinjelwe ukumuncwa komswakamo emkhathini. I-HPMC ivamise ukupakishwa ezikhwameni ezivikela umswakama noma iziqukathi ezenziwe ngezinto ezifana ne-polyethylene noma amalayini anezingqimba eziningi ukuze ivikeleke kumswakama. Ukupakishwa kuqinisekisa ukuthi okuqukethwe umswakama kuhlala ngaphakathi kwebanga elifiswayo ngesikhathi sokugcina nokuthutha.
Ukulawulwa Kokuqukethwe Komswakama Kwezokukhiqiza
Ngesikhathi sokwenziwa kwe-HPMC, kubalulekile ukuqapha nokulawula okuqukethwe komswakama ukuze kugcinwe ikhwalithi yomkhiqizo. Lokhu kungafinyelelwa ngokusebenzisa:
Amasu Okomisa:I-HPMC ingomiswa kusetshenziswa umoya oshisayo, i-vacuum drying, noma izikomisi ezijikelezayo. Izinga lokushisa nobude besikhathi sokumisa kufanele kuthuthukiswe ukuze kugwenywe kokubili ukomiswa okuncane (okunomswakama ophezulu) kanye nokomisa ngokweqile (okungase kuholele ekulimazeni okushisayo).
Ukulawulwa Kwemvelo:Ukugcina indawo elawulwayo enomswakama ophansi endaweni yokukhiqiza kubalulekile. Lokhu kungabandakanya okokususa umswakama, isimo somoya, kanye nokusetshenziswa kwezinzwa zomswakama ukuze kuqashwe izimo zomkhathi ngesikhathi sokucubungula.
Okuqukethwe umswakama I-HPMCngokuvamile iwela phakathi kwebanga elingu-7% ukuya ku-10%, nakuba lingahluka kuye ngezinga, uhlelo lokusebenza, nezimo zokulondoloza. Okuqukethwe komswakamo kuyipharamitha ebalulekile ethinta izici ze-rheological, ukunyibilika, nokuzinza kwe-AnxinCel®HPMC. Abakhiqizi nabakhi kumele balawule ngokucophelela futhi baqaphe okuqukethwe komswakama ukuze baqinisekise ukusebenza kahle ezinhlelweni zabo zokusebenza ezithile.
Isikhathi sokuthumela: Jan-20-2025