I-Hydroxypropyl methylcellulose (HPMC)i-non-ionic cellulose ether esetshenziswa kabanzi ezintweni zokwakha, imithi, ukudla, izimonyo nezinye izimboni. Izinkomba zobuchwepheshe eziyinhloko ze-HPMC zihlanganisa izakhiwo zomzimba namakhemikhali, ukuncibilika, i-viscosity, izinga lokushintshwa, njll.
1. Ukubukeka kanye nezici eziyisisekelo
I-HPMC ivamise ukuba yimpushana emhlophe noma emhlophe, engenaphunga, ayinambitheki, engenabuthi, enokuncibilika okuhle kwamanzi nokuzinza. Ingahlakazeka ngokushesha futhi incibilike emanzini abandayo ukuze yakhe isixazululo se-colloidal esobala noma esithuthukile kancane, futhi ibe nokuncibilika okungalungile kuzinyibilikisi zemvelo.
2. I-Viscosity
I-Viscosity ingenye yezinkomba zezobuchwepheshe ezibaluleke kakhulu ze-HPMC, enquma ukusebenza kwe-AnxinCel®HPMC ezinhlelweni ezahlukene. I-viscosity ye-HPMC ngokuvamile ikalwa njengesixazululo esinamanzi esingu-2% ku-20°C, futhi ububanzi be-viscosity obuvamile busuka ku-5 mPa·s kuya ku-200,000 mPa·s. Ukuphakama kwe-viscosity, kunamandla umphumela wokuqina wesixazululo futhi ngcono i-rheology. Uma isetshenziswa ezimbonini ezifana nezokwakha kanye nemithi, ibanga elifanele le-viscosity kufanele likhethwe ngokuya ngezidingo ezithile.
3. Okuqukethwe kwe-Methoxy kanye ne-Hydroxypropoxy
Izici zamakhemikhali ze-HPMC zinqunywa ngokuyinhloko i-methoxy (–OCH₃) ne-hydroxypropoxy (–OCH₂CHOHCH₃) amadigri ayo esikhundleni. I-HPMC enamadigri ahlukile ahlukile abonisa ukunyibilika okuhlukile, umsebenzi ongaphezulu kanye nezinga lokushisa le-gelation.
Okuqukethwe kwe-Methoxy: Ngokuvamile phakathi kuka-19.0% no-30.0%.
Okuqukethwe kwe-Hydroxypropoxy: Ngokuvamile phakathi kuka-4.0% no-12.0%.
4. Okuqukethwe Umswakama
Umswakamo we-HPMC uvamise ukulawulwa ku-≤5.0%. Umswakama ophezulu uzothinta ukuzinza kanye nomthelela wokusetshenziswa komkhiqizo.
5. Okuqukethwe Umlotha
Umlotha uyinsalela ngemva kokushiswa kwe-HPMC, ikakhulukazi kusawoti wezinto ezingaphili ezisetshenziswa enqubweni yokukhiqiza. Okuqukethwe komlotha kuvame ukulawulwa kokuthi ≤1.0%. Okuqukethwe komlotha okuphezulu kakhulu kungase kuthinte obala nobumsulwa be-HPMC.
6. Ukuncibilika nokungafihli
I-HPMC inokuncibilika okuhle kwamanzi futhi ingancibilika ngokushesha emanzini abandayo ukuze yakhe isixazululo se-colloidal esifanayo. Ukucaca kwesixazululo kuncike ekuhlanzekeni kwe-HPMC kanye nenqubo yayo yokuhlakazwa. Isixazululo sekhwalithi ephezulu se-HPMC sivamise ukuba sobala noma sibisi kancane.
7. Gel Temperature
Isixazululo samanzi se-HPMC sizokwakha ijeli ekushiseni okuthile. Izinga lokushisa lejeli layo ngokuvamile liphakathi kuka-50 no-90°C, kuye ngokuqukethwe kwe-methoxy ne-hydroxypropoxy. I-HPMC enokuqukethwe okuphansi kwe-methoxy inezinga lokushisa lejeli eliphakeme, kuyilapho i-HPMC enokuqukethwe okuphezulu kwe-hydroxypropoxy inezinga lokushisa eliphansi lejeli.
8. inani le-pH
Inani le-pH lesisombululo samanzi se-AnxinCel®HPMC ngokuvamile liphakathi kuka-5.0 no-8.0, elingathathi hlangothi noma eline-alkaline elibuthakathaka futhi elifanele izindawo ezihlukahlukene zokusetshenziswa.
9. Usayizi Wezinhlayiya
Ukucoleka kwe-HPMC kuvame ukuvezwa njengephesenti elidlula kusikrini esingu-80-mesh noma 100-mesh. Ngokuvamile kudingekile ukuthi u-≥98% udlule esikrinini esinemeshi engu-80 ukuze kuqinisekiswe ukuthi sinokuhlakazeka okuhle nokuncibilika lapho sisetshenziswa.
10. Okuqukethwe kwensimbi esindayo
Okuqukethwe kwensimbi esindayo (njengomthofu ne-arsenic) ye-HPMC kufanele ihambisane namazinga emboni afanelekile. Ngokuvamile, okuqukethwe okuholayo kungu-≤10 ppm futhi okuqukethwe kwe-arsenic kungu-≤3 ppm. Ikakhulukazi ebangeni lokudla nelemithi ye-HPMC, izidingo zokuqukethwe kwensimbi esindayo ziqine kakhulu.
11. Izinkomba ze-Microbial
Ngebanga lemithi nelokudla i-AnxinCel®HPMC, ukungcoliswa kwamagciwane kufanele kulawulwe, okuhlanganisa inani eliphelele lamakholoni, isikhunta, imvubelo, i-E. coli, njll., ngokuvamile edinga:
Isibalo sekholoni esiphelele ≤1000 CFU/g
Inani lesikhunta nemvubelo ≤100 CFU/g
I-E. coli, i-Salmonella, njll. akumele itholwe
12. Izindawo zokufaka izicelo eziyinhloko
I-HPMC isetshenziswa kabanzi ezimbonini eziningi ngenxa yokuqina kwayo, ukugcinwa kwamanzi, ukwakhiwa kwefilimu, ukugcotshwa, i-emulsification nezinye izakhiwo:
Imboni yezokwakha: Njenge-ejenti ejiyayo negcina amanzi odakeni lukasimende, impushana ye-putty, i-adhesive yethayela, kanye nenamathela ekungangeni kwamanzi ukuze kuthuthukiswe ukusebenza komsebenzi wokwakha.
Imboni yezemithi: Isetshenziswa njengento enamathelayo, ekhishwa njalo, kanye nempahla eluhlaza yegobolondo lamaphilisi ezidakamizwa.
Imboni yokudla: isetshenziswa njenge-emulsifier, i-stabilizer, i-thickener, isetshenziswa kujeli, iziphuzo, izinto ezibhakwayo, njll.
Imboni yamakhemikhali yansuku zonke: isetshenziswa njenge-thickener ne-emulsifier stabilizer emikhiqizweni yokunakekelwa kwesikhumba, okokuhlanza, nama-shampoos.
Izinkomba zobuchwepheshe zeI-HPMCzihlanganisa i-viscosity, i-degree of substitution (okuqukethwe kweqembu le-hydrolyzed), umswakama, okuqukethwe komlotha, inani le-pH, izinga lokushisa le-gel, ubuhle, okuqukethwe kwensimbi esindayo, njll. Lezi zinkomba zinquma ukusebenza kwayo kwesicelo emikhakheni ehlukene. Lapho bekhetha i-HPMC, abasebenzisi kufanele banqume ukucaciswa okufanele ngokuya ngezidingo ezithile zohlelo lokusebenza ukuze kuqinisekiswe umphumela wokusebenzisa ongcono kakhulu.
Isikhathi sokuthumela: Feb-11-2025