I-Cellulose, enye yezinhlanganisela ezitholakala kakhulu eMhlabeni, ithola ukusetshenziswa okubanzi ezimbonini ezahlukahlukene ngenxa yezakhiwo zayo ezihlukile. Embonini yezemithi, i-cellulose kanye nokuphuma kwayo kudlala indima ebalulekile ezinhlelweni zokulethwa kwezidakamizwa, ukwakhiwa kwamaphilisi, ukubopha amanxeba, nokunye.
1. I-Binder Ekwakhiweni Kwethebhulethi:
Okuphuma ku-cellulose okufana ne-microcrystalline cellulose (MCC) kanye ne-cellulose eyimpushana kusebenza njengezibophezelo ezisebenzayo ekwakhiweni kwethebhulethi. Athuthukisa ukuhlangana namandla emishini yamaphilisi, aqinisekise ukusatshalaliswa kwezidakamizwa okufanayo kanye namaphrofayili okukhululwa angaguquki.
2. I-Disintegrant:
Okuphuma ku-cellulose njenge-croscarmellose sodium ne-sodium carboxymethyl cellulose (NaCMC) kusebenza njengama-disintegrants kumaphilisi, okwenza kube lula ukuhlukana ngokushesha kwe-matrix yethebhulethi lapho kuthintana noketshezi olunamanzi. Lesi sakhiwo sithuthukisa ukuchithwa kwezidakamizwa kanye ne-bioavailability.
3. Izinhlelo Ezilawulwayo Zokulethwa Kwezidakamizwa:
Okuphuma kokuphuma ku-cellulose kuyizingxenye ezibalulekile ekwakhiweni kokukhishwa okulawulwayo. Ngokushintsha ukwakheka kwamakhemikhali noma usayizi wezinhlayiyana ze-cellulose, amaphrofayli aqhubekayo, anwetshiwe, noma ahlosiwe okukhishwa kwezidakamizwa angafinyelelwa. Lokhu kuvumela ukulethwa kwezidakamizwa okuthuthukisiwe, ukunciphisa imvamisa yomthamo, kanye nokuthobela isiguli okuthuthukisiwe.
4. Izinto Zokuhlanganisa:
Okuphuma ku-cellulose okufana ne-ethyl cellulose ne-hydroxypropyl methylcellulose (HPMC) kuvame ukusetshenziswa njengezingubo zefilimu zamaphilisi nama-granules. Zinikeza umgoqo ovikelayo, zifihla ukuthanda okungajabulisi, zilawule ukukhululwa kwezidakamizwa, futhi zithuthukise ukuzinza.
5. I-ejenti Yokuqina Nokuqina:
Ama-cellulose ethers afana ne-HPMC kanye ne-sodium carboxymethyl cellulose asetshenziswa njengama-ejenti aqinisayo futhi aqinisayo kumafomu omthamo owuketshezi njengokumiswa, ama-emulsion, nama-syrups. Bathuthukisa i-viscosity, bavimbele ukubola, futhi baqinisekise ukusatshalaliswa kwezidakamizwa okufanayo.
6. Isiza Ekwenziweni Kwezihloko:
Ekwakhiweni kwezihloko ezifana nokhilimu, amafutha okugcoba, namajeli, okuphuma ku-cellulose kusebenza njengezilungisi ze-viscosity, ama-emulsifiers, neziqinisi. Banikeza izici ezifiselekayo ze-rheological, bathuthukise ukusabalala, futhi bakhuthaze ukunamathela esikhumbeni noma kulwelwesi lwamafinyila.
7. Ukugqoka Amanxeba:
Izinto ezisekelwe ku-cellulose, okuhlanganisa i-cellulose e-oxidized ne-carboxymethyl cellulose, zisetshenziswa ekugqokeni amanxeba ngenxa yezakhiwo zazo ze-hemostatic, absorbent, kanye ne-antimicrobial. Lezi zingubo zokugqoka zikhuthaza ukuphulukiswa kwesilonda, zivimbele ukutheleleka, futhi zigcine indawo yamanxeba emanzi.
8. I-scaffold in Tissue Engineering:
Izikafula zeCellulose zinikeza i-matrix evumelana ne-biocompatible ne-biodegradable yezinhlelo zokusebenza zobunjiniyela bezicubu. Ngokuhlanganisa ama-bioactive agents noma amaseli, ama-scaffolds asekelwe ku-cellulose angasekela ukuvuselelwa kwezicubu kanye nokulungiswa kwezimo ezihlukahlukene zezokwelapha.
9. Ukwakhiwa kwe-Capsule:
Okuphuma ku-cellulose okufana ne-hypromellose ne-hydroxypropyl cellulose asetshenziswa njengezinto zokwakha i-capsule, enikeza enye indlela yama-gelatin capsules. Amaphilisi asekelwe ku-cellulose afaneleka kokubili ukwakhiwa kokukhishwa okusheshayo nokushintshiwe futhi ancanyelwa emikhawulweni yemifino noma yezenkolo.
10. Inkampani Yenethiwekhi Ezinhlelweni Zokuhlakazeka Eziqinile:
Ama-cellulose nanoparticles athole ukunakwa njengabathwali bezidakamizwa ezingancibiliki kahle emanzini ezinhlelweni eziqinile zokuhlakazeka. Indawo yabo ephezulu, i-porosity, kanye ne-biocompatibility kusiza ukuqedwa kwezidakamizwa okuthuthukisiwe kanye nokuba khona kwe-bioavailability.
11. Izicelo Zokulwa Nokwenziwa Komgunyathi:
Izinto ezisekelwe ku-cellulose zingafakwa emaphaketheni emithi njengezinyathelo zokulwa nomgunyathi. Amathegi ahlukile asuselwa ku-cellulose noma amalebula anezici zokuphepha ezishumekiwe angasiza ukuqinisekisa imikhiqizo yemithi futhi anqande abazenzisi.
12. Ukulethwa Kwezidakamizwa Eziphefumulayo:
Okuphuma ku-cellulose okufana ne-microcrystalline cellulose ne-lactose asetshenziswa njengezithwali zokwakheka kokuhogela kwempushana eyomile. Lezi zithwali ziqinisekisa ukuhlakazeka okufanayo kwezidakamizwa futhi zenze kube lula ukulethwa okuphumelelayo emgudwini wokuphefumula.
i-cellulose kanye nokuphuma kwayo kusebenza njengezinto ezisizayo nezisetshenziswa ngezindlela eziningi embonini yezemithi, okunikela ekuthuthukisweni kwemikhiqizo yezidakamizwa ephephile, esebenzayo, nelungele isiguli. Izakhiwo zabo ezihlukile zivumela ukusetshenziswa okubanzi, kusukela ekwakhiweni kwethebhulethi kuya ekunakekelweni kwamanxeba kanye nobunjiniyela bezicubu, okwenza i-cellulose ibe ingxenye ebaluleke kakhulu ekwenziweni kwemithi yesimanje kanye namathuluzi ezokwelapha.
Isikhathi sokuthumela: Apr-18-2024