IHydroxypropyl Methylcellulose (HPMC)iyi-polymer encibilika emanzini evame ukusetshenziswa embonini yezemithi, yezimonyo neyokudla. Ngenxa yokuncibilika kwamanzi okuhle kakhulu kanye nezakhiwo zokulungiswa kwe-viscosity, i-HPMC isetshenziswa kabanzi kumajeli, amafomu omthamo olawulwa yizidakamizwa, ukumiswa, ama-thickeners neminye imikhakha. Izinhlobo ezahlukene kanye nokucaciswa kwe-HPMC kunezinga lokushisa elihlukile, ikakhulukazi lapho ulungiselela amajeli e-HPMC, izinga lokushisa linethonya elibalulekile ekuncibilikeni kwayo, i-viscosity kanye nokuzinza.
Ukuqedwa kwe-HPMC kanye nebanga lokushisa lokwakheka kwejeli
Izinga lokushisa lokuqedwa
I-HPMC ivamise ukuncibilika emanzini anamanzi ashisayo, futhi izinga lokushisa lokuncibilika lincike esisindweni sayo samangqamuzana kanye nezinga le-methylation ne-hydroxypropylation. Ngokuvamile, izinga lokushisa lokuqedwa le-HPMC lisukela ku-70°C kuya ku-90°C, futhi izinga lokushisa elithile lokuncibilika lithintwa ukucaciswa kwe-HPMC kanye nokugxila kwesixazululo. Isibonelo, i-HPMC ene-viscosity ephansi ivamise ukuncibilika ekushiseni okuphansi (okungaba ngu-70°C), kuyilapho i-HPMC ene-viscosity ephezulu ingase idinge izinga lokushisa eliphezulu (eliseduze no-90°C) ukuze incibilike ngokuphelele.
I-Gel Formation Temperature (I-Gelation Temperature)
I-HPMC inendawo eyingqayizivele yejeli ye-thermoreversible, okungukuthi, izokwakha ijeli ngaphakathi kwebanga elithile lokushisa. Izinga lokushisa lejeli le-HPMC lithinteka kakhulu isisindo salo samangqamuzana, ukwakheka kwamakhemikhali, ukuhlushwa kwesisombululo nezinye izithasiselo. Ngokuvamile, izinga lokushisa lejeli le-HPMC livamise ukuba ngu-35°C kuya ku-60°C. Ngaphakathi kwalolu hlu, amaketango e-molecular e-HPMC azohlela kabusha ukuze akhe uhlaka lwenethiwekhi olunezinhlangothi ezintathu, okubangela ukuthi isisombululo sishintshe sisuke esimweni soketshezi siye esimweni sejeli.
Izinga lokushisa elithile lokwakheka kwejeli (okungukuthi, izinga lokushisa le-gelation) linganqunywa ngokuhlola. Izinga lokushisa le-gelation yejeli ye-HPMC ngokuvamile lincike ezintweni ezilandelayo:
Isisindo samangqamuzana: I-HPMC enesisindo samangqamuzana aphezulu ingakha ijeli ekushiseni okuphansi.
Ukugxila kwesixazululo: Uma kuphezulu ukugxila kwesisombululo, izinga lokushisa lokwakheka kwejeli livame ukuba liphansi.
Izinga le-methylation kanye nezinga le-hydroxypropylation: I-HPMC enezinga eliphezulu le-methylation ngokuvamile yakha ijeli ekushiseni okuphansi ngoba i-methylation inyusa ukusebenzisana phakathi kwama-molecule.
Umthelela wezinga lokushisa
Ezisetshenziswa ezingokoqobo, izinga lokushisa linomthelela omkhulu ekusebenzeni nasekuzinzeni kwejeli ye-HPMC. Amazinga okushisa aphakeme akhuphula uketshezi lwamaketanga e-molecular HPMC, ngaleyo ndlela athinte ukuqina nezici zokuncibilika kwejeli. Ngokuphambene nalokho, izinga lokushisa eliphansi lingase lenze buthaka ukugeleza kwejeli ye-HPMC futhi lenze isakhiwo sejeli singazinzi. Ngaphezu kwalokho, ukushintsha kwezinga lokushisa kungase futhi kubangele ukusebenzisana phakathi kwama-molecule e-HPMC kanye noshintsho ku-viscosity yesixazululo.
Ukuziphatha kwe-HPMC gelation ku-pH ehlukile namandla e-ionic
Ukuziphatha kwe-gelation kwe-HPMC akuthintwa izinga lokushisa kuphela, kodwa futhi yi-pH namandla e-ionic esisombululo. Isibonelo, ukuncibilika nokuziphatha kwe-gelation kwe-HPMC ngamavelu e-pH ahlukene kuzohluka. Ukunyibilika kwe-HPMC kungase kuncishiswe ezindaweni ezine-asidi, kuyilapho ukunyibilika kwayo kungase kwenyuswe ezindaweni ezine-alkali. Ngokufanayo, ukwanda kwamandla e-ionic (njengokwengezwa kosawoti) kuzothinta ukusebenzisana phakathi kwama-molecule e-HPMC, ngaleyo ndlela kushintshe ukwakheka nokuzinza kwejeli.
Ukusetshenziswa kwejeli ye-HPMC nezici zayo zokushisa
Izici zokushisa zejeli ye-HPMC ziyenza isetshenziswe kabanzi ekukhululweni kwezidakamizwa, ukulungiswa kwezimonyo neminye imikhakha:
Ukukhishwa kwezidakamizwa okulawulwayo
Emalungiselelweni ezidakamizwa, i-HPMC ivame ukusetshenziswa njenge-matrix yokukhululwa elawulwayo, futhi izakhiwo zayo ze-gelation zisetshenziselwa ukulawula izinga lokukhululwa kwezidakamizwa. Ngokulungisa izinga lokushisa lokuhlushwa kanye ne-gelation ye-HPMC, ukukhishwa kwezidakamizwa kungalawulwa ngokunembile. Ukushintsha kwezinga lokushisa kwezidakamizwa emgudwini wamathumbu kungakhuthaza ukuvuvukala kwejeli ye-HPMC kanye nokukhululwa kancane kancane kwezidakamizwa.
Izimonyo Nemikhiqizo Yokunakekela Umuntu
I-HPMC ivamise ukusetshenziswa kuzimonyo ezifana nokuthambisa, amajeli, izifutho zezinwele, nokhilimu besikhumba. Ngenxa yokuzwela kwayo kwezinga lokushisa, i-HPMC ingalungisa ukuthungwa nokuzinza kwemikhiqizo ngaphansi kwezimo ezihlukene zokushisa. Ukushintsha kwezinga lokushisa ekwenziweni kwezimonyo kunomthelela omkhulu ekuziphatheni kwe-gelation kwe-HPMC, ngakho-ke ukucaciswa okufanele kwe-HPMC kumele kukhethwe ngokucophelela lapho kudizayinwa imikhiqizo.
Imboni Yokudla
Ekudleni, i-HPMC isetshenziswa kabanzi njenge-thickener ne-emulsifier, ikakhulukazi ekudleni okulungele ukudliwa naseziphuzweni. Izakhiwo zayo ezizwelayo kukushisa zivumela i-HPMC ukuthi iguqule isimo sayo somzimba ngesikhathi sokushisisa noma ukupholisa, ngaleyo ndlela ithinte ukunambitheka nokwakheka kokudla.
Izici zokushisa zeI-HPMCamajeli ayisici esibalulekile ekusebenzeni kwawo. Ngokulungisa izinga lokushisa, ukugxilisa ingqondo, nokuguqulwa kwamakhemikhali, izakhiwo zamajeli e-HPMC, njengokuncibilika, amandla ejeli, nokuzinza, zingalawulwa ngokunembile. Izinga lokushisa lokwakheka kwejeli livamise ukuba phakathi kuka-35°C no-60°C, kuyilapho izinga lokushisa layo lokuncibilika livamise ukuba ngu-70°C kuya ku-90°C. I-HPMC isetshenziswa kakhulu embonini yezemithi, yezimonyo, neyokudla ngenxa yokuziphatha kwayo kwe-gelation eyingqayizivele eshisayo kanye nokuzwela kwezinga lokushisa.
Isikhathi sokuthumela: Jan-16-2025