1. I-Croscarmellose sodium(i-CMCNa exhunywe ngokuphambanayo): i-copolymer exhumene kakhulu ye-CMCNa
Izakhiwo: Impushana emhlophe noma emhlophe. Ngenxa yesakhiwo esixhumene nesiphambano, ayincibiliki emanzini; ikhukhumala ngokushesha emanzini izikhathi ezingu-4-8 umthamo wayo wokuqala. Impushana ine-fluidity enhle.
Isicelo: Kuyinto evame ukusetshenziswa super disintegrant. I-Disintegrant yamaphilisi omlomo, amaphilisi, ama-granules.
2. I-Carmellose calcium (i-CMCa exhunywe ngokuphambanayo):
Izakhiwo: Impushana emhlophe, engenaphunga, i-hygroscopic. Isixazululo esingu-1% pH 4.5-6. Cishe ayincibiliki ku-ethanol ne-ether solvent, ayincibiliki emanzini, ayincibiliki ku-dilute hydrochloric acid, inyibilika kancane ku-alkali encibilikayo. noma impushana emhlophe. Ngenxa yesakhiwo esixhumene nesiphambano, ayincibiliki emanzini; liyakhukhumala lapho limunca amanzi.
Isicelo: ithebhulethi disintegrant, binder, diluent.
3. I-Methylcellulose (MC):
Isakhiwo: i-methyl ether ye-cellulose
Izakhiwo: Impushana emhlophe ukuya kokuphuzi emhlophe noma ama-granules. Ayincibiliki emanzini ashisayo, isixazululo sikasawoti esigcwele, utshwala, i-ether, i-acetone, i-toluene, i-chloroform; Incibilika ku-glacial acetic acid noma ingxube elinganayo yotshwala ne-chloroform. Ukuncibilika emanzini abandayo kuhlobene nezinga lokushintshwa, futhi kuncibilika kakhulu uma izinga lokushintsha lingu-2.
Isicelo: i-tablet binder, i-matrix ye-ejenti ehlakazekayo yethebhulethi noma ukulungiswa kokukhishwa okuqhubekayo, ukhilimu noma ijeli, i-ejenti elengayo kanye ne-ejenti yokuqina, ukumbozwa kwethebhulethi, i-emulsion stabilizer.
4. I-Ethyl cellulose (EC):
Isakhiwo: I-Ethyl ether ye-cellulose
Izakhiwo: Impushana emhlophe noma ephuzi-mhlophe nama-granules. Ayincibiliki emanzini, oketshezini lwamathumbu, i-glycerol ne-propylene glycol. Incibilika kalula ku-chloroform ne-toluene, futhi yakha imvula emhlophe uma kune-ethanol.
Isicelo: Impahla efanelekile yenkampani yenethiwekhi engancibiliki emanzini, efaneleke njenge-matrix yezidakamizwa engezwani namanzi, isithwali esingancibiliki emanzini, isibophezelo sethebhulethi, impahla yefilimu, impahla ye-microcapsule kanye nokokunamathela okukhishwa okuqhubekayo, njll.
5. I-Hydroxyethyl Cellulose (HEC):
Isakhiwo: Ingxenye ye-hydroxyethyl ether ye-cellulose.
Izakhiwo: Impushana ephuzi ngokukhanyayo noma emhlophe ebisi. Incibilika ngokugcwele emanzini abandayo, emanzini ashisayo, i-asidi ebuthakathaka, isisekelo esibuthakathaka, i-asidi eqinile, isisekelo esiqinile, engancibiliki kuma-solvents amaningi e-organic (i-soluble ku-dimethyl sulfoxide, i-dimethylformamide), ku-diol polar organic solvents Inganwetshwa noma incibilike kancane.
Izicelo: Izinto ze-polymer ezincibilika emanzini ezingezona i-ionic; ama-thickeners okulungiselela i-ophthalmic, i-otology kanye nokusetshenziswa kwe-topical; I-HEC kumafutha okugcoba amehlo omile, amalensi okuxhumana nomlomo owomile; ezisetshenziswa izimonyo. Njenge-binder, i-ejenti eyenza ifilimu, i-ejenti yokuqina, i-ejenti yokumisa kanye ne-stabilizer yezidakamizwa nokudla, ingafaka izinhlayiya zezidakamizwa, ukuze izinhlayiya zezidakamizwa zidlale indima yokukhululwa kancane.
6. I-Hydroxypropyl Cellulose (HPC):
Isakhiwo: Ingxenye ye-polyhydroxypropyl ether ye-cellulose
Izakhiwo: I-HPC efakwe endaweni ephezulu imhlophe noma impushana ephuzi kancane. Incibilika ku-methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide kanye ne-dimethyl formamide, inguqulo ephakeme ye-viscosity ayincibiliki kalula. Ayincibiliki emanzini ashisayo, kodwa ingavuvukala. I-Thermal Gelation: incibilika kalula emanzini angaphansi kuka-38°C, igayiwe ngokushisisa, futhi yakha ukuvuvukala kwe-flocculent ku-40-45°C, okungatholakala ngokupholisa.
Izici ezivelele ze-L-HPC: ezingancibiliki emanzini nasezincibilikisini eziphilayo, kodwa ezivuvukalayo emanzini, futhi impahla evuvukalayo iyanda ngokwanda kwezinto ezibambile.
Isicelo: I-HPC efakwe endaweni ephezulu isetshenziswa njengesibophezelo sethebhulethi, i-ejenti ye-granulating, izinto zokumboza ifilimu, futhi ingasetshenziswa njengempahla yefilimu ene-microencapsulated, impahla ye-matrix kanye nezinto ezisizayo zethebhulethi yokugcinwa kwesisu, i-thickener ne-Protective colloids, nayo evame ukusetshenziswa kuma-patches e-transdermal.
I-L-HPC: Isetshenziswa kakhulu njenge-disintegrant yethebhulethi noma i-binder ye-granulation emanzi, njenge-matrix yethebhulethi ekhishwa okuqhubekayo, njll.
7. I-Hypromellose (HPMC):
Isakhiwo: Ingxenye ye-methyl nengxenye ye-polyhydroxypropyl ether ye-cellulose
Izakhiwo: Impushana emhlophe noma emhlophe noma i-granular. Iyancibilika emanzini abandayo, ayincibiliki emanzini ashisayo, futhi inezakhiwo ze-thermal gelation. Iyancibilika ku-methanol ne-ethanol solutions, i-chlorinated hydrocarbons, i-acetone, njll. Ukuncibilika kwayo kuzinyibilikisi zemvelo kungcono kunokuncibilika emanzini.
Isicelo: Lo mkhiqizo uyisisombululo samanzi esine-viscosity ephansi esisetshenziswa njengento yokumboza ifilimu; isisombululo se-organic solvent high-viscosity sisetshenziswa njenge-tablet binder, futhi umkhiqizo we-viscosity ephezulu ungasetshenziswa ukuvimba i-matrix yokukhululwa kwezidakamizwa ezincibilika emanzini; njengoba iso lehla i-thickener ye-lacquer nezinyembezi zokwenziwa, kanye ne-ejenti yokumanzisa ama-contact lens.
8. I-Hypromellose Phthalate (HPMCP):
Isakhiwo: I-HPMCP i-phthalic acid half ester ye-HPMC.
Izakhiwo: I-Beige noma ama-flakes amhlophe noma ama-granules. Ayincibiliki emanzini nesisombululo esimuncu, ayincibiliki ku-hexane, kodwa incibilika kalula ku-acetone:methanol, acetone:ethanol noma methanol:ingxube ye-chloromethane.
Uhlelo lokusebenza: Uhlobo olusha lwezinto zokumboza ezisebenza kahle kakhulu, ezingasetshenziswa njengefilimu ukuvala iphunga elingavamile lamaphilisi noma ama-granules.
9. I-Hypromellose Acetate Succinate (HPMCAS):
Isakhiwo: I-acetic ehlanganisiwe ne-succinic esters yeI-HPMC
Izakhiwo: Impushana emhlophe ukuya kokuphuzi emhlophe noma ama-granules. Incibilika ku-sodium hydroxide ne-sodium carbonate solution, incibilika kalula ku-acetone, i-methanol noma i-ethanol: emanzini, i-dichloromethane:ingxube ye-ethanol, ayincibiliki emanzini, i-ethanol ne-ether.
Isicelo: Njengengxenye ye-tablet enteric enamathela, impahla enamathelayo yokukhululwa okuqhubekayo kanye nezinto zokumboza ifilimu.
10. I-Agari:
Isakhiwo: I-Agar iyingxube okungenani yama-polysaccharide amabili, cishe u-60-80% we-agarose engathathi hlangothi kanye no-20-40% we-agarose. I-Agarose yakhiwe amayunithi aphindayo e-agarobiose lapho i-D-galactopyranosose ne-L-galactopyranosose ixhunywe ngokushintshana ku-1-3 naku-1-4.
Izakhiwo: I-Agar iyashintshashintsha, isilinda esiyisikwele esiphuzi ngokukhanyayo, umucu ozacile noma i-scaly flake noma into eyimpuphu. Ayincibiliki emanzini abandayo, incibilika emanzini abilayo. Ivuvukala izikhathi ezingu-20 emanzini abandayo.
Isicelo: Njenge-ejenti ebophayo, isisekelo sokugcoba, isisekelo se-suppository, i-emulsifier, i-stabilizer, i-ejenti yokumisa, futhi njenge-poultice, i-capsule, isiraphu, i-jelly ne-emulsion.
Isikhathi sokuthumela: Apr-26-2024