Ukuqonda i-Hydroxypropyl Methyl Cellulose (HPMC)
IHydroxypropyl Methyl Cellulose (HPMC) iyi-polymer eguquguqukayo esetshenziswa kabanzi ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ukudla, izimonyo, nezokwakha. Izakhiwo zayo eziyingqayizivele, njengokuncibilika kwamanzi, i-gelation phezu kokushisa, kanye nekhono lokwenza ifilimu, kuyenza ibe isithako esibalulekile ekwakhekeni okuningi. Enye yezinto ezibalulekile ze-HPMC yi-viscosity yayo, enomthelela kakhulu ekusebenzeni kwayo nasekusetshenzisweni kwayo.
Izinto Ezithonya I-Viscosity ye-HPMC
Kunezici ezimbalwa ezithinta i-viscosity ye-HPMC, kufaka phakathi:
Isisindo samangqamuzana: Amamaki e-HPMC anesisindo esiphezulu samangqamuzana ngokuvamile abonisa i-viscosity ephezulu.
Ukugxila: I-viscosity iyanda ngokugxila kwe-HPMC esixazululweni.
Izinga lokushisa: I-Viscosity iyancipha ngokukhuphuka kwezinga lokushisa ngenxa yamaketanga e-polymer ahamba kancane.
I-pH: I-HPMC izinzile kulo lonke uhla lwe-pH olubanzi, kodwa amazinga e-pH adlulele angathinta i-viscosity.
I-Degree of Substitution (DS) kanye ne-Molar Substitution (MS): Izinga lokushintsha (inani lamaqembu e-hydroxyl elithathelwe indawo amaqembu e-methoxy noma i-hydroxypropyl) kanye nokushintshwa kwe-molar (inombolo yamaqembu e-hydroxypropyl ngeyunithi ngayinye ye-glucose) kuthonya ukunyibilika kanye ne-viscosity ye-HPMC
I-Viscosity Efanelekile Yezicelo Ezihlukene
I-viscosity efanele ye-HPMC incike kuhlelo lokusebenza oluthile. Nakhu ukubuka okuningiliziwe kokuthi izidingo ze-viscosity zihluka kanjani kuzo zonke izimboni ezahlukene:
1. Imithi
Kwezemithi, i-HPMC isetshenziswa njenge-binder, ifilimu-yangaphambili, kanye ne-ejenti ekhishwa okulawulwayo kumaphilisi namaphilisi.
I-Tablet Coating: I-viscosity ephansi kuya emaphakathi I-HPMC (isixazululo esingu-3-5% esinama-50-100 cps) ifanele ukumbozwa kwefilimu, ihlinzeka ngesendlalelo esibushelelezi, esivikelayo.
Ukukhishwa okulawulwayo: I-viscosity ephezulu ye-HPMC (isixazululo esingu-1% esine-1,500-100,000 cps) sisetshenziswa kumathebhulethi e-matrix ukulawula izinga lokukhululwa kwesithako esisebenzayo, ukuqinisekisa ukukhululwa okuqhubekayo ngokuhamba kwesikhathi.
I-Binder in Granulation: I-HPMC ye-viscosity emaphakathi (isixazululo esingu-2% esino-400-4,000 cps) siyakhethwa ezinqubweni ze-granulation ezimanzi ukuze zakhe ama-granules anamandla amahle omshini.
2. Imboni Yokudla
Embonini yokudla, i-HPMC isetshenziswa njenge-thickener, stabilizer, kanye ne-emulsifier.
I-Ejenti Ewugqinsi: I-viscosity ephansi kuya emaphakathi I-HPMC (isixazululo esingu-1-2% esino-50-4,000 cps) sisetshenziselwa ukujiyisa amasoso, okokugqoka, namasobho.
I-Emulsifier ne-Stabilizer: I-viscosity ephansi I-HPMC (isixazululo esingu-1% esine-10-50 cps) ifanele ukuqiniswa kwe-emulsion namagwebu, inikeze ukuthungwa okufiselekayo emikhiqizweni efana no-ayisikhilimu kanye nokugcotshwa okuphehliwe.
3. Izimonyo Nokunakekela Umuntu
I-HPMC isetshenziswa ezimonyoni ngenxa yokujiya kwayo, ukwenza ifilimu, kanye nezakhiwo zokuthambisa.
Ama-lotions nama-Creams: I-HPMC ye-viscosity ephansi kuya ephakathi (isixazululo esingu-1% esino-50-4,000 cps) sinikeza ukuvumelana nokuqina okufunayo.
Imikhiqizo Yokunakekelwa Kwezinwele: I-HPMC ye-viscosity emaphakathi (isixazululo esingu-1% esino-400-4,000 cps) sisetshenziswa kuma-shampoos nama-conditioner ukuthuthukisa ukuthungwa nokusebenza.
4. Imboni Yezokwakha
Ekwakhiweni, i-HPMC iyingxenye ebalulekile emikhiqizweni efana nezinamatheliso zamathayela, amaplasta, nezinto ezisekelwe usimende.
Izinamatheliso Zamathayela namaGrouts: I-HPMC ye-viscosity emaphakathi kuya phezulu (isixazululo esingu-2% esine-4,000-20,000 cps) ithuthukisa ukusebenza, ukugcinwa kwamanzi, kanye nezakhiwo zokunamathela.
Ama-Cement Plaster: I-HPMC ye-viscosity emaphakathi (isixazululo esingu-1% esinama-cps angu-400-4,000) sithuthukisa ukugcinwa kwamanzi nokusebenza, ukuvimbela ukuqhekeka nokuthuthukisa isiphetho.
I-Viscosity Measurement kanye namazinga
I-Viscosity ye-HPMC ivamise ukukalwa kusetshenziswa i-viscometer, futhi imiphumela ichazwa nge-centipoise (cps). Izindlela ezijwayelekile ezifana ne-Brookfield viscometry noma i-capillary viscometry zisetshenziswa kuye ngobubanzi be-viscosity. Ukukhethwa kwebanga elifanele le-HPMC kuqondiswa yizicaciso ezinikezwe abakhiqizi, okubandakanya amaphrofayili e-viscosity anemininingwane.
Ukucatshangelwa Okuwusizo
Lapho ukhetha i-HPMC yohlelo oluthile, kufanele kucatshangelwe izinto ezimbalwa ezisebenzayo:
Ukulungiselela Isixazululo: Ukufakwa kwe-hydration efanele kanye nokuhlakazeka kubalulekile ukuze kuzuzwe i-viscosity oyifunayo. Ukwengeza kancane kancane emanzini ngokunyakazisa okuqhubekayo kusiza ukuvimbela ukwakheka kwesigaxa.
Ukuhambisana: Ukuhambisana kwe-HPMC nezinye izithako zokwakheka kufanele kuhlolwe ukuze kuqinisekiswe ukuzinza nokusebenza kahle.
Izimo Zokugcina: I-Viscosity ingathinteka izimo zokugcina ezifana nezinga lokushisa kanye nomswakama. Ukugcinwa okufanele endaweni epholile, neyomile kubalulekile ukugcina ikhwalithi ye-HPMC.
I-viscosity efanelekile ye-Hydroxypropyl Methyl Cellulose (HPMC) iyahlukahluka kakhulu kuye ngesicelo, kusukela ku-viscosity ephansi ye-emulsification kanye nokuqiniswa emikhiqizweni yokudla kuya ku-viscosity ephezulu yokukhishwa kwezidakamizwa okulawulwayo emithini yemithi. Ukuqonda izidingo ezithile zomkhakha ngamunye kanye nesicelo kubalulekile ekukhetheni ibanga elilungile le-HPMC, ukuqinisekisa ukusebenza okuphelele nokusebenza kahle. Ngokucabangela izici ezifana nesisindo samangqamuzana, ukugxilisa ingqondo, izinga lokushisa, kanye ne-pH, abakhiqizi bangakwazi ukulungisa izixazululo ze-HPMC ukuze zihlangabezane nezidingo zokwakheka ezinembile.
Isikhathi sokuthumela: May-22-2024