I-Hydroxypropyl methylcellulose (HPMC)ifilimu inokusebenza okuhle kakhulu, kodwa ngenxa yokuthi i-HPMC iyijeli elishisayo, i-viscosity ekushiseni okuphansi iphansi kakhulu, engahambisani nokugqoka (noma ukucwilisa) nokomisa ekushiseni okuphansi ukuze kulungiswe ifilimu edliwayo, okuholela ekusebenzeni kabi kokucubungula; ngaphezu kwalokho, izindleko zayo eziphakeme zikhawulela ukusetshenziswa kwayo. I-Hydroxypropyl isitashi (HPS) ijeli elibandayo elishibhile, ukungezwa kwayo kungakhuphula i-viscosity ye-HPMC ekushiseni okuphansi, kuthuthukise ukusebenza kokucubungula kwe-HPMC, futhi kunciphise izindleko zokukhiqiza, ngokuqhubekayo, i-hydrophilicity efanayo , amayunithi e-glucose namaqembu e-hydroxypropyl konke kunomthelela ekuthuthukiseni ukuhambisana kwalawa ma-polymers amabili. Ngakho-ke, uhlelo lokuhlanganisa ijeli elibandayo lwalungiswa ngokuhlanganisa i-HPS ne-HPMC, futhi umphumela wokushisa esakhiweni sejeli ye-HPMC/HPS ye-hot-cold gel blend system yacwaningwa ngendlela ehlelekile ngokusebenzisa i-rheometer kanye namasu amancane okuhlakazeka kwe-X-ray. , kuhlanganiswe nomthelela wezimo zokwelashwa kokushisa ku-microstructure kanye nezakhiwo zesistimu ye-membrane, bese kwakha ubudlelwano phakathi kwesakhiwo sejeli se-blend system-membrane structure-membrane properties ngaphansi kwezimo zokwelashwa kokushisa.
Imiphumela ibonisa ukuthi ekushiseni okuphezulu, ijeli enezinga eliphezuluI-HPMCokuqukethwe kunemodulus ephezulu kanye nokuziphatha okuqinile okufana nokuqinile, ukwakheka okuzifaniselayo kwama-gel scatterers kuminyene, futhi usayizi wama-gel aggregate mkhulu; ezingeni lokushisa eliphansi, okuqukethwe kwe-HPS Amasampula ejeli aphezulu anemodulus ephezulu, ukuziphatha okugqame kakhulu okufana nokuqinile, kanye nesakhiwo esiminyene esizifanayo sama-scatterers wejeli. Kumasampuli anesilinganiso esifanayo sokuxuba, imodulus nokubaluleka kokuziphatha okuqinile kanye nokuminyana kwesakhiwo esizifaniselayo samajeli abuswa yi-HPMC kumazinga okushisa aphezulu aphakeme kunalawo abuswa i-HPS emazingeni okushisa aphansi. Ukushisa okomisa kungathinta ukwakheka kwejeli yesistimu ngaphambi kokoma, bese kuthinta isakhiwo se-crystalline kanye nesakhiwo se-amorphous sefilimu, futhi ekugcineni sibe nomthelela obalulekile ezindaweni zomshini wefilimu, okuholela ekuqineni kwamandla kanye ne-modulus yefilimu omisiwe ekushiseni okuphezulu. Iphakeme kunokomile ekushiseni okuphansi. Izinga lokupholisa alinawo umthelela osobala esakhiweni se-crystalline sohlelo, kodwa linomthelela ekushubeni kwe-microdomain umzimba ofana nawo wefilimu. Kulesi simiso, ukuminyana kwesakhiwo esizimele sefilimu singathinta izakhiwo zemishini zefilimu. Ukusebenza kunomthelela omkhulu.
Ngokusekelwe ekulungiseleleni ulwelwesi oluhlanganisiwe, ucwaningo lwathola ukuthi ukusetshenziswa kwesisombululo se-iodine ukudaya ngokukhetha ulwelwesi oluhlanganisiwe lwe-HPMC/HPS kusungule indlela entsha yokubuka ngokucacile ukusatshalaliswa kwesigaba kanye noshintsho lwesigaba sesistimu ehlanganisiwe ngaphansi kwesibonakhulu. indlela, enokubaluleka kwesiqondiso se-methodological ocwaningweni lokusatshalaliswa kwesigaba sezinhlelo zokuhlanganisa ezisuselwe kwisitashi. Kusetshenziswa le ndlela entsha yocwaningo, ehlanganiswe ne-infrared spectroscopy, ukuskena i-electron microscopy kanye ne-extensometer, ukuguqulwa kwesigaba, ukuhambisana kanye nezakhiwo zemishini zesistimu zahlaziywa futhi zafundwa, futhi ukuhambisana, ukuguqulwa kwesigaba nokubukeka kwefilimu kwakhiwa. ubudlelwano phakathi kokusebenza. Imiphumela yokubhekwa kwe-microscope ibonisa ukuthi uhlelo ludlula ukuguqulwa kwesigaba lapho isilinganiso se-HPS singama-50%, futhi isenzakalo sokuxuba i-interphase sikhona kufilimu, okubonisa ukuthi uhlelo lunezinga elithile lokuhambisana; i-infrared, i-thermogravimetric analysis kanye nemiphumela ye-SEM iqhubeka nokuqinisekisa ukuhlangana. Uhlelo lunezinga elithile lokuhambisana. Imoduli yefilimu ehlanganisiwe iyashintsha lapho okuqukethwe kwe-HPS kungu-50%. Lapho i-I-HPSokuqukethwe kukhulu kuno-50%, i-engeli yokuxhumana yesampula ehlanganisiwe ichezuka emugqeni oqondile oxhuma ama-engeli okuxhumana amasampula amsulwa, futhi uma ingaphansi kuka-50%, ichezuka kabi kulo mugqa oqondile. , okubangelwa ikakhulukazi ukuguqulwa kwesigaba.
Isikhathi sokuthumela: Apr-25-2024