Umehluko phakathi kwe-Hydroxypropyl Methylcellulose ne-Hydroxyethyl Cellulose

IHydroxypropyl Methylcellulose (HPMC) futhiI-Hydroxyethyl Cellulose (HEC) womabili okuphuma ku-cellulose, asetshenziswa kakhulu embonini, kwezokwelapha, kwezimonyo nakweminye imikhakha. Umehluko wabo oyinhloko ubonakala ekwakhiweni kwamangqamuzana, izici ze-solubility, izinkambu zohlelo lokusebenza nezinye izici.

1. Isakhiwo samangqamuzana

IHydroxypropyl Methylcellulose (HPMC)

I-HPMC iwukuphuma kokuncibilika emanzini okwethulwa ngokwethula amaqembu e-methyl (-CH3) kanye ne-hydroxypropyl (-CH2CHOHCH3) ochungechungeni lwengqamuzana ye-cellulose. Ngokukhethekile, ukwakheka kwamangqamuzana e-HPMC kuqukethe izinto ezimbili ezisebenzayo, i-methyl (-OCH3) ne-hydroxypropyl (-OCH2CH(OH)CH3). Ngokuvamile, isilinganiso sesingeniso se-methyl siphezulu, kuyilapho i-hydroxypropyl ingathuthukisa ngempumelelo ukunyibilika kwe-cellulose.

I-Hydroxyethyl Cellulose (HEC)

I-HEC iwukuphuma kokunye okwethulwa ngokwethula amaqembu e-ethyl (-CH2CH2OH) ochungechungeni lwe-cellulose yamangqamuzana. Esakhiweni se-hydroxyethyl cellulose, iqembu elilodwa noma ngaphezulu le-hydroxyl (-OH) ye-cellulose lithathelwa indawo ngamaqembu e-ethyl hydroxyl (-CH2CH2OH). Ngokungafani ne-HPMC, ukwakheka kwamangqamuzana e-HEC kunengxenye eyodwa kuphela ye-hydroxyethyl futhi ayiqukethe amaqembu e-methyl.

2. Ukuncibilika kwamanzi

Ngenxa yomehluko wesakhiwo, ukuncibilika kwamanzi kwe-HPMC ne-HEC kuhlukile.

I-HPMC: I-HPMC inokunyibilika okuhle kwamanzi, ikakhulukazi kumanani e-pH angathathi hlangothi noma ane-alkaline, ukunyibilika kwayo kungcono kune-HEC. Ukwethulwa kwamaqembu e-methyl kanye ne-hydroxypropyl kuthuthukisa ukunyibilika kwayo futhi kungandisa i-viscosity yayo ngokusebenzisana nama-molecule amanzi.

I-HEC: I-HEC ivame ukuncibilika emanzini, kodwa ukuncibilika kwayo kumbi kakhulu, ikakhulukazi emanzini abandayo, futhi ngokuvamile idinga ukuchithwa ngaphansi kwezimo zokushisa noma idinga ukugxila okuphezulu ukuze kuzuzwe imiphumela efanayo ye-viscosity. Ukunyibilika kwayo kuhlobene nomehluko wesakhiwo se-cellulose kanye ne-hydrophilicity yeqembu le-hydroxyethyl.

3. Viscosity kanye rheological izakhiwo

I-HPMC: Ngenxa yokuba khona kwamaqembu amabili ahlukene e-hydrophilic (i-methyl ne-hydroxypropyl) kuma-molecule ayo, i-HPMC inezinto ezinhle zokulungisa i-viscosity emanzini futhi isetshenziswa kakhulu ezintweni ezinamathelayo, ezinamekayo, ezihlahleni, ekulungiseni imithi nakwezinye izinkambu. Ezimweni ezihlukene, i-HPMC ingahlinzeka ngokulungiswa ukusuka ku-viscosity ephansi ukuya ku-viscosity ephezulu, futhi i-viscosity izwela kakhulu ekushintsheni kwe-pH.

I-HEC: I-viscosity ye-HEC ingabuye ilungiswe ngokushintsha ukugxila, kodwa uhla lwayo lokulungiswa kwe-viscosity luncane kunalolo lwe-HPMC. I-HEC isetshenziswa kakhulu ezimweni lapho i-viscosity ephansi kuya ephakathi idingeka, ikakhulukazi ekwakhiweni, okokuhlanza kanye nemikhiqizo yokunakekelwa komuntu siqu. Izakhiwo ze-rheological ze-HEC zizinzile, ikakhulukazi ezindaweni ezine-acidic noma ezingathathi hlangothi, i-HEC inganikeza i-viscosity ezinzile.

4. Izinkambu zokufaka isicelo

I-Hydroxypropyl methylcellulose (HPMC)

Imboni yezokwakha: I-HPMC ivamise ukusetshenziswa odakeni lukasimende nasezimbotsheni embonini yezokwakha ukuze kuthuthukiswe uketshezi, ukusebenza kahle nokuvimbela imifantu.

Imboni yezemithi: Njenge-ejenti elawula ukukhishwa kwezidakamizwa, i-HPMC isetshenziswa kakhulu embonini yezemithi. Ngeke isetshenziswe kuphela njenge-ejenti yokwakha yamaphilisi nama-capsules, kodwa futhi njenge-adhesive ukusiza ukukhululwa kwezidakamizwa ngokulinganayo.

Imboni yokudla: I-HPMC ivamise ukusetshenziswa ekucubunguleni ukudla njengesiqinisi, ukuqina noma i-emulsifier ukuthuthukisa ukuthungwa nokunambitha kokudla.

Imboni yezimonyo: Njengokuqina, i-HPMC isetshenziswa kakhulu emikhiqizweni efana nokhilimu, ama-shampoos, nama-conditioner ukukhulisa i-viscosity nokuzinza kwemikhiqizo.

I-Hydroxyethyl cellulose (HEC)

Imboni yezokwakha: I-HEC ivamise ukusetshenziswa kusimende, igypsum, nezinamatheliso zamathayela ukuze kuthuthukiswe ukugeleza kwamanzi kanye nesikhathi sokugcinwa komkhiqizo.

Abahlanza: I-HEC ivame ukusetshenziswa ezihlanzini zasendlini, okokuhlanza izingubo neminye imikhiqizo ukwandisa i-viscosity yomkhiqizo futhi kuthuthukiswe umphumela wokuhlanza.

Imboni yezimonyo: I-HEC isetshenziswa kakhulu emikhiqizweni yokunakekelwa kwesikhumba, amajeli eshawa, ama-shampoos, njll. njenge-ejenti ejiyayo nemisayo ukuze kuthuthukiswe ukuthungwa nokuzinza komkhiqizo.

Ukukhipha uwoyela: I-HEC ingasetshenziswa futhi ekukhishweni kukawoyela njenge-thickener emanzini okumba asekelwe emanzini ukusiza ukwandisa i-viscosity yoketshezi futhi kuthuthukise umphumela wokumba.

5. Ukuzinza kwe-pH

I-HPMC: I-HPMC izwela kakhulu ekushintsheni kwe-pH. Ngaphansi kwezimo ezine-acidic, ukuncibilika kwe-HPMC kuncipha, okungase kuthinte ukusebenza kwayo. Ngakho-ke, ngokuvamile isetshenziswa endaweni engathathi hlangothi ukuya endaweni ene-alkaline.

I-HEC: I-HEC ihlala izinzile ku-pH ebanzi. Inokuvumelana nezimo okuqinile ezindaweni ezine-acidic kanye ne-alkaline, ngakho-ke ivame ukusetshenziswa ekwakhiweni okudinga ukuzinza okuqinile.

I-HPMCfuthiI-HECziyahlukahluka ngesakhiwo samangqamuzana, ukuncibilika, ukusebenza kokulungiswa kwe-viscosity, kanye nezindawo zokusebenzisa. I-HPMC inokuncibilika okuhle kwamanzi nokusebenza kokulungiswa kwe-viscosity, futhi ifanele izinhlelo zokusebenza ezidinga i-viscosity ephezulu noma ukusebenza okuqondile kokukhishwa okulawulwayo; kuyilapho i-HEC inokuqina okuhle kwe-pH kanye nohlu olubanzi lwezinhlelo zokusebenza, futhi ifanele izikhathi ezidinga i-viscosity ephakathi nendawo kanye nokuvumelana nezimo kwemvelo okuqinile. Ekusetshenzisweni kwangempela, ukukhetha ukuthi iyiphi impahla edinga ukuhlolwa ngokusekelwe ezidingweni ezithile.