Isimo sokuthuthukiswa kobuchwepheshe bokukhiqiza be-HPMC kanye nenqubo ye-hydroxypropyl methyl cellulose e-China

Isimo sokuthuthukiswa kobuchwepheshe bokukhiqiza be-HPMC kanye nenqubo ye-hydroxypropyl methyl cellulose e-China

I-Hydroxypropyl methyl celluloseI-HPMCekukhiqizeni kwasekhaya kwamanje kunikezwa kuqala nge-liquid phase method technology, lobu buchwepheshe bumelelwa yi-wuxi chemical industry research and design Institute e-China iyunithi yocwaningo ngeminyaka yawo-1970, impumelelo yocwaningo ngesisekelo sokugqugquzelwa, i-original iyona indlela yegesi yesigaba se-etherification yokusabela, ngoba imishini ayihambisani nezwe lethu, yabe isisebenza ngaphandle kwesigaba se-liquid indlela etherification yokusabela, Kuze kube manje inqubo yokukhiqiza i-ether ephezulu iyindlela yokukhiqiza uketshezi eyaziwayo. abakhiqizi be-cellulose ether.

I-domestic hydroxypropyl methyl cellulose Ukukhiqizwa kwe-HPMC ngokuvamile kusebenzisa ukotini ocolile njengempahla eluhlaza (abanye abakhiqizi nabo baqala ukuzama ukusebenzisa uginindela wokhuni), futhi ukugaya ukugaya kwasekhaya noma ukusebenzisa ngokuqondile ukucwenga ukotini alkalization, i-etherification kusetshenziswa i-solvent ehlanganisiwe kanambambili, ukusabela ku-reactor eqondile. Inqubo yokuhlanza isebenzisa inqubo yesikhashana lapho i-solvent yemvelo ikhishwa ku-reactor futhi umkhiqizo ongahluziwe uhlanzwa ngokugeza okuningana kanye nokuphelelwa amanzi emzimbeni ngokusebenzisa izihlikihli nama-centrifuges. Iqediwe ukucutshungulwa komkhiqizo nge-granulation ephakathi, ngaphansi kwesimo sokushisa (kukhona nomkhiqizi ngaphandle kwe-granulation), ukomisa nokuchoboza ngendlela evamile, iningi lokucubungula okukhethekile liwukubambezeleka nje isikhathi sokuchithwa komkhiqizo (ukuncibilika ngokushesha) ukucubungula ngaphandle kokuvimbela isikhutha nokusabalalisa ukucubungula, ukupakisha sebenzisa indlela yezandla.

Indlela yesigaba se-liquid inezinzuzo ezilandelayo: imishini yenqubo yokusabela ingcindezi yangaphakathi incane, izidingo zomthamo wemishini ziphansi, ingozi encane; Ngemuva kokukhulelwa ku-lye,i-celluloseinganwetshwa ngokugcwele futhi yenziwe i-alkali ngokulinganayo. I-Lye inokungena kangcono nokuvuvukala kwe-cellulose. I-reactor etherification incane, ihambisana nokuvuvukala komfaniswano we-alkali cellulose, ngakho-ke ikhwalithi yomkhiqizo kulula ukuyilawula, i-substitution degree kanye ne-viscosity ingatholakala imikhiqizo efanayo, izinhlobonhlobo nazo zilula ukushintshwa.

Kodwa-ke, le nqubo nayo inezinkinga ezilandelayo: i-reactor ngokuvamile ayinkulu kakhulu, ukulinganiselwa kwezibalo kuholela kumthamo omncane wokukhiqiza, ukuze kuthuthukiswe okukhiphayo, kuyadingeka ukwandisa inani lama-reactors; Imikhiqizo engahluziwe ecolisisiwe nehlanjululwe idinga imishini eyengeziwe, ukusebenza okuyinkimbinkimbi, umfutho wabasebenzi; Ngoba akukho anti-mildew kanye nokwelashwa okuhlanganisiwe, okuholela ekuzinzeni kwe-viscosity yomkhiqizo kanye nezindleko zokukhiqiza ziyathinteka; Ukupakisha ngendlela yezandla, umfutho wabasebenzi, izindleko eziphezulu zabasebenzi; Idigri ye-automation yokulawula ukusabela iphansi kunaleyo yenqubo yesigaba segesi, ngakho ukunemba kokulawula kuphansi kakhulu. Uma kuqhathaniswa nenqubo yesigaba segesi, izinhlelo zokubuyisela i-solvent eziyinkimbinkimbi ziyadingeka.

Ngokuthuthukiswa kwe-hydroxypropyl methyl cellulose yasekhayaI-HPMCubuchwepheshe bokukhiqiza, amanye amabhizinisi ngokuqamba okusha okuqhubekayo okuzimele, indlela yesigaba soketshezi lweketela elikhulu iye yathuthukiswa ngokugxuma nezindlela, futhi inezici zayo zobuchwepheshe. I-Anxin chemistry isebenzisa inqubo yokukhiqiza ye-HPMC yasekuqaleni, hhayi kuphela inqubo yokukhiqiza enengqondo, imingcele yokulawula ukusebenza inembile futhi inokwethenjelwa, ukusetshenziswa okugcwele nokunengqondo kwezinto ezingavuthiwe nezinye izici, kanye neziqu zokushintsha umkhiqizo zifana, ukusabela kuphelele ngokuphelele, ukukhanya kwesixazululo kuhle, futhi ngesikhathi esifanayo ukuqinisekisa ukuzinza kwekhwalithi yomkhiqizo. Umugqa wokukhiqiza we-HPMC wamanye amabhizinisi uguqulwe ngokuzenzakalelayo, ukuze kuzuzwe izidingo zokulawula okuzenzakalelayo zedivayisi ye-DCS, izinto zokwakha ezihlanganisa uketshezi, izinto zokusetshenziswa eziqinile zingasetshenziswa ukulinganisa ngokunembile futhi wengeze uhlelo lwe-DCS, izinga lokushisa nokulawula ingcindezi kunqubo yokusabela konke kuqashelwe ukulawulwa okuzenzakalelayo kwe-DCS nokuqapha okukude, Ngokuya nokwenzeka, ukwethembeka, ukuzinza nokuphepha kokukhiqiza, ngokusobala akusiyo imodi yokukhiqiza yendabuko ethuthukisiwe kuphela, imodi yokukhiqiza ayithuthukisiwe kuphela. umfutho, kodwa futhi ithuthukisa indawo yokusebenza esizeni.