Izici zobuchwepheshe bokushisa okuphezulu kwe-hydroxypropyl methylcellulose

I-Hydroxypropyl methylcellulose (HPMC)kuyinto ebalulekile yamakhemikhali, esetshenziswa kabanzi ezintweni zokwakha, imithi, ukudla kanye neminye imikhakha. Ikakhulukazi embonini yezokwakha, i-HPMC isetshenziswa kabanzi ngenxa yokusebenza kwayo okuhle kakhulu. Ubuchwepheshe bokushisa okuphezulu budlala indima ebalulekile ekukhiqizeni nasekusetshenzisweni kwe-HPMC.

1. Indima yobuchwepheshe bokushisa okuphezulu ku-HPMC

ukukhiqizwa I-Hydroxypropyl methylcellulose itholakala ngochungechunge lokusabela kwamakhemikhali okufana ne-alkalization kanye ne-etherification ye-cellulose yemvelo. Ubuchwepheshe bokushisa obuphezulu busetshenziswa ikakhulukazi ezigabeni zokuqedwa, zomiswe kanye nokubumba zenqubo yokusabela. Ukwelashwa kokushisa okuphezulu akukwazi nje ukusheshisa izinga lokuphendula, kodwa futhi kuthuthukise ukuhlanzeka nokuzinza komkhiqizo.

Ukusebenza kahle kokusabela okuthuthukisiwe

Ngaphansi kwezimo zokushisa eziphakeme, izinga lokuphendula le-cellulose ne-sodium hydroxide liyashesha, elikhuthaza ukusabela kwe-hydroxypropyl kanye ne-methyl esikhundleni sama-molecule e-cellulose, ngaleyo ndlela kuthuthukiswe izinga lokushintshwa (DS) nokufana kwe-HPMC.

Susa ukungcola

Indawo yokushisa ephezulu ingasusa ngempumelelo imikhiqizo ekhiqizwe ngesikhathi sokusabela, njengesixazululo se-alkali esingaphenduliwe kanye ne-solvent, futhi ithuthukise ubumsulwa be-HPMC.

Ukwenza ngcono ukomisa ukusebenza kahle

Ngesikhathi senqubo yokumisa izinga lokushisa eliphezulu, umswakama we-HPMC uyahwamuka ngokushesha, ugwema umkhiqizo ukuthi ungahlangani noma ungabi namazinga okushisa aphansi, futhi uthuthukise ukuzinza nokusebenza kokugcinwa komkhiqizo.

2. Umthelela wobuchwepheshe bezinga lokushisa eliphezulu ekusebenzeni kwe-HPMC

Ubuchwepheshe bezinga lokushisa eliphezulu abuthinti nje kuphela isakhiwo somzimba se-HPMC, kodwa futhi bunomthelela omkhulu kumakhemikhali ayo kanye nemiphumela yokusetshenziswa kwayo.

Ukulungiswa kwe-viscosity

Inqubo yokushisa ephezulu ingalawula ngempumelelo ukusatshalaliswa kwesisindo samangqamuzana e-HPMC, ngaleyo ndlela ilungise i-viscosity yayo. Amazinga okushisa aphezulu asiza ukunciphisa amathuba okuphuka kweketango lamangqamuzana, okwenza i-viscosity ye-HPMC kusisombululo esinamanzi izinze kakhudlwana.

Ukumelana nokushisa okuthuthukisiwe

Ukuzinza okushisayo kwe-HPMC kuthuthukiswa kakhulu ngokwelashwa okunezinga lokushisa eliphezulu. Ekwakheni udaka namathayela anamathelayo, i-HPMC isengakwazi ukugcina izakhiwo ezinhle zokunamathela kanye nezokulwa nokuntenga ngaphansi kwezimo zokushisa eziphezulu.

Ukunyibilika okuthuthukisiwe

Ngesikhathi senqubo yokumisa izinga lokushisa eliphezulu, i-microstructure ye-HPMC iyathuthukiswa, iyenze incibilike kakhulu emanzini abandayo. Ikakhulukazi ezindaweni zokwakha ezisezingeni eliphansi, i-HPMC ingancibilika ngokushesha futhi yakhe isisombululo se-colloidal esifanayo.

3. Ukusetshenziswa okuqondile kobuchwepheshe bokushisa okuphezulu kwinqubo yokukhiqiza ye-HPMC

Isiteji sokusabela se-Etherification

Ngokwenza ukusabela kwe-etherification ezingeni lokushisa eliphezulu lika-80-100°C, ukusabela kokufakwa esikhundleni kwe-hydroxypropyl namaqembu e-methyl kungasheshiswa, ukuze i-HPMC ibe nezinga eliphezulu lokushintsha kanye nokuzinza okungcono.

Isiteji sokumisa nokuchoboza

Ubuchwepheshe bokomisa umoya oshisayo ngaphezu kwe-120 ° C abukwazi nje ukususa umswakama, kodwa futhi buvimbele i-HPMC powder ekuhlanganiseni phakathi nenqubo yokomisa. Kamuva, ubuchwepheshe bokuchoboza izinga lokushisa eliphezulu busetshenziselwa ukwenza izinhlayiya ze-HPMC zempushana zibe buthakathaka futhi zifane, futhi ukuhlakazeka komkhiqizo kuyathuthukiswa.

Ukushisa okuphezulu kokwelapha ukwelashwa

Lapho i-HPMC isetshenziswa ezintweni zokwakha noma okokuhlanganisa, ukwelapha okuphulukisa izinga lokushisa eliphezulu kungathuthukisa ukumelana kwayo nokuqhekeka, ukumelana ne-sag nokusebenza kokugcinwa kwamanzi, kuqinisekise umphumela omuhle wokwakha ezindaweni ezinokhahlo.

4. Izinzuzo zobuchwepheshe bokushisa okuphezulu emikhakheni yesicelo se-HPMC

Izinto zokwakha

Ngaphansi kwesimo sokushisa okuphezulu, i-HPMC ikhombisa ukujiya okuhle kakhulu nokugcinwa kwamanzi odakeni kanye ne-putty powder, ukuvimbela udaka ekuphelelweni kwamanzi ngokushesha nokuqhekeka.

Imboni kapende

I-HPMC ehlanganiswe izinga lokushisa eliphezulu inemiphumela emihle yokulinganisa kanye ne-anti-sagging kupende we-latex, othuthukisa ukunamathela nokumelana nokugqokwa kokunamathela.

Imboni yezemithi

Ubuchwepheshe bezinga lokushisa eliphezulu bungathuthukisa ukufana kwe-HPMC embotsheni yezidakamizwa futhi kuqinisekise ukuzinza komphumela wokukhululwa oqhubekayo wesidakamizwa.

Ukusetshenziswa kobuchwepheshe bokushisa okuphezulu kwei-hydroxypropyl methylcelluloseakugcini nje ukuthuthukisa ukusebenza kahle kokukhiqiza, kodwa futhi kuthuthukisa ukusebenza komkhiqizo. Ngenqubo yokushisa ephezulu, i-viscosity, ukunyibilika kanye nokuzinza okushisayo kwe-HPMC kuye kwathuthukiswa kakhulu, okuyenza ibe nethemba elibanzi lesicelo emikhakheni yokwakha, ukumboza kanye nemithi. Ngokuzayo, ngokusungulwa okuqhubekayo kobuchwepheshe bokushisa okuphezulu, ukusebenza kwe-HPMC kuzothuthukiswa nakakhulu, kube negalelo elikhulu ekuthuthukisweni kwezinto eziluhlaza kanye nemvelo.