IHydroxypropyl Methylcellulose (HPMC)yipolima enyibilikayo emanzini eqhele ukusetyenziswa kumayeza, ukutya, izinto zokuthambisa, kunye namashishini okwakha. Isiqulatho sokufuma se-HPMC sidlala indima ebalulekileyo ekusetyenzweni nasekuzinzeni kwayo. Ichaphazela iipropati ze-rheological, ukunyibilika, kunye nobomi beshelufu bezinto eziphathekayo. Ukuqonda umxholo wokufuma kubalulekile ekuqulunqweni kwawo, ukugcinwa, kunye nokusetyenziswa kokuphela kokusetyenziswa.
Umxholo wokufuma we-HPMC
Ubumanzi be-AnxinCel®HPMC bugqitywe ngokubanzi ngeemeko zenkqubo kunye nebakala elithile lepolymer esetyenzisiweyo. Ubumanzi bunokwahluka ngokuxhomekeke kwizinto ezikrwada, iimeko zokugcina, kunye nenkqubo yokomisa. Ngokuqhelekileyo ibonakaliswa njengepesenti yobunzima besampulu ngaphambi nangemva kokumisa. Ukusetyenziswa kwemizi-mveliso, umxholo wokufuma ubalulekile, njengoko ukufuma okugqithisileyo kunokukhokelela ekuthotyweni, ekudibaneni, okanye ekucuthekeni kokusebenza kwe-HPMC.
Isiqulatho sokufuma se-HPMC sinokusuka kwi-5% ukuya kwi-12%, nangona uluhlu oluqhelekileyo luphakathi kwe-7% kunye ne-10%. Isiqulatho sokufuma sinokumiselwa ngokomisa isampuli kwiqondo lobushushu elithile (umzekelo, i-105 ° C) de ifikelele kubunzima obungaguqukiyo. Umahluko kubunzima phambi nasemva kokomisa umele ukufuma.
Izinto ezichaphazela isiqulatho sokufuma kwi-HPMC
Izinto ezininzi zinokuphembelela umxholo wokufuma we-HPMC:
Ukufuma kunye neeMeko zokuGcina:
Ukufuma okuphezulu okanye iimeko zokugcina ezingafanelekanga zinokunyusa umthamo wokufuma we-HPMC.
I-HPMC yi-hygroscopic, oku kuthetha ukuba ithande ukufunxa ukufuma kumoya oyingqongileyo.
Ukupakishwa kunye nokutywinwa kwemveliso kunokunciphisa ukufunxa ukufuma.
Iimeko Zokusebenza:
Ubushushu bokomisa kunye nexesha ngexesha lokwenziwa kwemveliso kunokuchaphazela umxholo wokufuma wokugqibela.
Ukomisa ngokukhawuleza kunokubangela ukufuma okushiyekileyo, ngelixa ukomisa kade kusenokubangela ukuba kugcinwe ukufuma.
IBanga le-HPMC:
Amabanga ahlukeneyo e-HPMC (umzekelo, i-viscosity ephantsi, i-viscosity ephakathi, okanye i-viscosity ephezulu) ingaba neziqulatho zokufuma eziguquguqukayo ngenxa yomahluko kulwakhiwo lwemolekyuli kunye nokusetyenzwa.
IiNgcaciso zoMboneleli:
Ababoneleli banokubonelela i-HPMC ngesiqulatho sokufuma esicacisiweyo esihambelana nemigangatho yoshishino.
Isiqulatho sokuFumana esiSiseko se-HPMC ngokweBanga
Isiqulatho sokufuma se-HPMC siyahluka ngokuxhomekeke kwibakala kunye nokusetyenziswa okucetywayo. Nantsi itheyibhile ebonisa amanqanaba esiqulatho sokufuma aqhelekileyo kumabanga ahlukeneyo e-HPMC.
| IBanga leHPMC | Viscosity (cP) | Isiqulatho sokufuma (%) | Usetyenziso |
| Viscosity ephantsi HPMC | 5 – 50 | 7 – 10 | Amachiza (iipilisi, iipilisi), izithambiso |
| Medium Viscosity HPMC | 100 - 400 | 8 – 10 | Amachiza (ukukhululwa okulawulwayo), ukutya, ukunamathela |
| High Viscosity HPMC | 500 - 2000 | 8 – 12 | Ulwakhiwo (olusekwe kwisamente), ukutya (i-arhente yokutyebisa) |
| I-HPMC yezamayeza | 100 - 4000 | 7 – 9 | Iipilisi, iingubo ze-capsule, i-gel formulations |
| Ukutya-iBanga HPMC | 50 - 500 | 7 – 10 | Ukuqina kokutya, i-emulsification, iingubo |
| IBanga loKwakha HPMC | 400 - 10000 | 8 – 12 | Udaka, i-adhesives, i-plasters, imixube eyomileyo |
Uvavanyo kunye nokumiselwa koMxholo wokufuma
Kukho iindlela ezininzi eziqhelekileyo zokumisela umxholo wokufuma we-HPMC. Ezona ndlela zimbini zixhaphakileyo zezi:
Indlela yeGravimetric (Ilahleko ekomisweni, LOD):
Le yeyona ndlela isetyenziswa kakhulu ekumiseleni umthamo wokufuma. Ubunzima obaziwayo be-HPMC bubekwe kwi-oven yokomisa ebekwe kwi-105°C. Emva kwexesha elichaziweyo (ngokuqhelekileyo iiyure ezingama-2-4), isampuli ilinganiswa kwakhona. Umahluko kubunzima unika umxholo wokufuma, obonakaliswa njengepesenti yobunzima besampulu yokuqala.
UKarl Fischer Titration:
Le ndlela ichaneke ngakumbi kune-LOD kwaye ibandakanya ukusabela kweekhemikhali ezilinganisa umthamo wamanzi. Le ndlela idla ngokusetyenziswa xa kufuneka uqinisekiso oluchanekileyo lokufuma.
Impembelelo yesiqulatho sokufuma kwiiPropati zeHPMC
Ubumanzi be-AnxinCel®HPMC buchaphazela ukusebenza kwayo kwizicelo ezahlukeneyo:
Viscosity:Isiqulatho sokufuma sinokuchaphazela i-viscosity yezisombululo ze-HPMC. Ukufuma okuphezulu kunokunyusa i-viscosity kwimixube ethile, ngelixa ukufuma okuphantsi kunokukhokelela kwi-viscosity ephantsi.
Ukunyibilika:Ukufuma okugqithisileyo kunokukhokelela kwi-agglomeration okanye ekunciphiseni ukunyibilika kwe-HPMC emanzini, kuyenza ingasebenzi kakuhle kwizicelo ezithile, ezinje ngemigaqo yokukhululwa elawulwayo kushishino lwamayeza.
Uzinzo:I-HPMC izinzile ngokubanzi kwiimeko ezomileyo, kodwa isiqulatho sokufuma esiphezulu sinokubangela ukukhula kwentsholongwane okanye ukuthotywa kweekhemikhali. Ngesi sizathu, i-HPMC igcinwa ngokwesiqhelo kwizikhongozeli ezitywiniweyo kwindawo ezinobumanzi obuphantsi.
Isiqulatho sokufuma kunye nokuPakisha kwe-HPMC
Ngenxa yobume be-hygroscopic ye-HPMC, ukupakishwa okufanelekileyo kubalulekile ukunqanda ukufunxa ukufuma emoyeni. I-HPMC idla ngokupakishwa kwiingxowa ezinobungqina bokufuma okanye izikhongozeli ezenziwe ngezinto ezifana ne-polyethylene okanye iilayiti ezininzi zokuyikhusela kumanzi. Ukupakishwa kuqinisekisa ukuba isiqulatho sokufuma sihlala ngaphakathi koluhlu olufunekayo ngexesha lokugcinwa nokuthutha.
Ulawulo loMxholo wokufuma kwiMveliso
Ngexesha lokwenziwa kwe-HPMC, kubalulekile ukubeka iliso nokulawula isiqulatho sokufuma ukugcina umgangatho wemveliso. Oku kunokufezekiswa ngokuthi:
Iindlela Zokomisa:I-HPMC inokomiswa kusetyenziswa umoya oshushu, ivacuum dryer, okanye izomisi ezijikelezayo. Ubushushu kunye nobude bexesha lokumisa kufuneka buphuculwe ukunqanda ukomisa ngaphantsi (umthamo wokufuma okuphezulu) kunye nokomisa kakhulu (okunokukhokelela ekuthotyweni kobushushu).
Ulawulo lokusingqongileyo:Ukugcina indawo elawulwayo kunye nokufuma okuphantsi kwindawo yemveliso kubalulekile. Oku kunokubandakanya i-dehumidifiers, i-air conditioning, kunye nokusetyenziswa kwezinzwa zokufuma ukujonga iimeko ze-atmospheric ngexesha lokucubungula.
Umxholo wokufuma we HPMCngokuqhelekileyo iwela phakathi koluhlu lwe-7% ukuya kwi-10%, nangona lunokwahluka ngokuxhomekeke kwibakala, isicelo, kunye neemeko zokugcina. Umxholo wobumanzi yiparameter ebalulekileyo echaphazela iimpawu ze-rheological, i-solubility, kunye nokuzinza kwe-AnxinCel®HPMC. Abavelisi kunye nabaqulunqi kufuneka balawule ngononophelo kwaye babeke iliso kwisiqulatho sokufuma ukuze baqinisekise ukusebenza kakuhle kwizicelo zabo ezithile.
Ixesha lokuposa: Jan-20-2025