Yintoni efakwe endaweni ephezulu ihydroxypropyl cellulose?

I-highly substituted hydroxypropyl cellulose (HSHPC) luhlobo olulungisiweyo lweselulosi, i-polysaccharide yendalo efumaneka kwizityalo. Le nto iphumayo yenziwa ngenkqubo yokuguqulwa kweekhemikhali apho amaqela e-hydroxypropyl aziswa kwi-cellulose backbone. Izinto ezibangelwayo zibonisa iipropati ezizodwa ezenza ukuba zixabiseke kwizicelo ezahlukeneyo zoshishino kunye namayeza.

I-Cellulose iqulethwe ngokuphindaphindiweyo kweeyunithi ze-glucose ezidityaniswe kunye ne-beta-1,4-glycosidic bonds. Yeyona polymer ininzi kakhulu emhlabeni kwaye isebenza njengenxalenye yesakhiwo kwiindonga zeeseli zezityalo. Nangona kunjalo, uhlobo lwayo lwendalo lunemida ngokubhekiselele kwi-solubility, iimpawu ze-rheological, kunye nokuhambelana nezinye izinto. Ngokuguqula iikhemikhali zeselulosi, izazinzulu zinokwenza iipropathi zayo zilungele usetyenziso oluthile.

Iselulosi yeHydroxypropyl (HPC)yinto eqhelekileyo eyenziwa yi-cellulose derivative eyenziwa yi-etherification ye-cellulose nge-propylene oxide. Olu tshintsho lwazisa amaqela e-hydroxypropyl kwi-cellulose backbone, inika ukunyibilika kumanzi kunye nezinyibilikisi eziphilayo. Nangona kunjalo, i-HPC yesiqhelo ayinakuhlala ihlangabezana neemfuno zezicelo ezithile ngenxa yenqanaba layo elilinganiselweyo lokutshintsha.

I-cellulose ye-hydroxypropyl efakwe endaweni ephezulu, njengoko igama libonisa, idlula inkqubo yokuguqulwa ebanzi, ekhokelela kwiqondo eliphezulu lokutshintshwa kwamaqela e-hydroxypropyl. Olu tshintsho lwandisiweyo lonyusa ukunyibilika kwepolymer, umthamo wokudumba, kunye neempawu zokwenza ifilim, kuyenza ibe luncedo ngakumbi kwizicelo ezizodwa apho ezi mpawu zibaluleke kakhulu.

Ukwenziwa kwe-HSHPC ngokuqhelekileyo kubandakanya ukusabela kweselulosi kunye nepropylene oxide phambi kwe-catalyst phantsi kweemeko ezilawulwayo. Iqondo lokutshintsha lingahlengahlengiswa ngeparameters ezahlukeneyo ezifana nexesha lokusabela, ubushushu, kunye nomlinganiselo wereactants. Ngokusebenzisa ngononophelo, abaphandi banokufikelela kwinqanaba elinqwenelekayo lokutshintshwa ukuze bahlangabezane neendlela ezithile zokusebenza.

Esinye sezicelo eziphambili ze-HSHPC kushishino loxubo-mayeza, apho lusebenza njengomncedisi oguquguqukayo kuqulunqo lwamachiza. Abaxhamli zizithako ezingasebenziyo zongezwa kwiimveliso zamayeza ukuphucula ukwenziwa kwazo, ukuzinza, ukubakho kwezinto eziphilayo, kunye nokwamkeleka kwesigulane. I-HSHPC ixatyiswe ngokukodwa ngokukwazi kwayo ukusebenza njenge-binder, disintegrant, ifilimu yangaphambili, kunye ne-viscosity modifier kwiifom ezahlukeneyo zedosi.

Kuqulunqo lwepilisi, i-HSHPC ingasetyenziswa njengesibophelelo ukubamba izithako ezisebenzayo kunye, ukuqinisekisa ukuhanjiswa kweyeza okufanayo kunye nokuhanjiswa kwedosi engaguqukiyo. I-solubility yayo ephezulu ivumela ukuchithwa ngokukhawuleza kweepilisi xa kufakwe, kuququzelele ukukhutshwa kweziyobisi kunye nokufunxa emzimbeni. Ngaphezu koko, iipropathi zefilimu ze-HSHPC zenza ukuba zilungele iipilisi zokugquma, zibonelela ngokhuseleko kumswakama, ukukhanya, kunye ne-oxidation, kunye nokufihla incasa engathandekiyo okanye ivumba.

Ukongeza kwiipilisi, i-HSHPC ifumana izicelo kwezinye iifom zedosi ezifana neegranules, iipellets, ii-capsules, kunye ne-topical formulations. Ukuhambelana kwayo kunye noluhlu olubanzi lwezithako ezisebenzayo zamachiza (APIs) kunye nabanye abaxhamli benza ukuba kube yinto ekhethiweyo yokukhetha abaqulunqi abafuna ukunyusa iinkqubo zokuhanjiswa kweyeza.

Ngaphandle kweshishini lamachiza, i-HSHPC isetyenziswa kwizicelo ezahlukeneyo zemizi-mveliso, kubandakanywa izincamathelisi, iingubo, iimveliso zokhathalelo lomntu, kunye nezongezo zokutya. Iipropati zayo zokwenza ifilimu kunye nokuqina zenza ukuba zixabiseke kwi-adhesive formulations yephepha, ukupakisha kunye nezinto zokwakha. Kwiingubo, i-HSHPC inokuphucula iimpawu zokuhamba, ukunamathela, kunye nokumelana nokufuma kwepeyinti, i-varnishes, kunye ne-sealants.

Kwiimveliso zokhathalelo lomntu ezifana nezithambiso, i-HSHPC isebenza njenge-thickener, stabilizer, kunye ne-emulsifier kwiikhrimu, izinto zokuthambisa, iishampu, kunye neegels. Ubuchule bayo bokuphucula i-viscosity kunye nokubonelela ngokugudileyo, ukuthungwa okukhazimlayo kuyenza ibe sesona sithako sithandwayo kukhathalelo lwesikhumba kunye nolwakhiwo lweenwele. Ngaphezu koko, i-biocompatibility ye-HSHPC kunye ne-non-toxicity iyenza ilungele ukusetyenziswa kwiimveliso zokhathalelo lomlomo ezifana nentlama yamazinyo kunye nokuhlamba umlomo.

I-cellulose ye-hydroxypropyl efakwe endaweni ephezulu yipolymer eguquguqukayo kunye noluhlu olubanzi lwezicelo kumayeza, izithambiso, izinto zokuncamathelisa, iingubo kunye namanye amashishini. Inhlanganisela yayo ekhethekileyo yokunyibilika, amandla okuvuvukala, iipropati zokwenza ifilimu, kunye ne-biocompatibility yenza ukuba ibe yinto ebaluleke kakhulu kwimiqulu eyahlukeneyo, igalelo ekuphuhliseni iimveliso ezintsha ezihlangabezana neemfuno zeemarike ezahlukeneyo kunye nabathengi.