IHydroxypropyl methylcellulose (HPMC)yi-ether ye-cellulose engekho i-ionic esetyenziswa ngokubanzi kwizinto zokwakha, amayeza, ukutya, izimonyo kunye namanye amashishini. Iimpawu eziphambili zezobugcisa ze-HPMC ziquka iipropati zomzimba kunye neekhemikhali, ukunyibilika, i-viscosity, i-degree of substitution, njl.
1. Ukubonakala kunye neempawu ezisisiseko
I-HPMC idla ngokuba ngumgubo omhlophe okanye ongekho-mhlophe, ongenavumba, ongenancasa, ongenatyhefu, kunye nokunyibilika kakuhle kwamanzi kunye nokuzinza. Inokusasazeka ngokukhawuleza kwaye inyibilike emanzini abandayo ukwenza isisombululo se-colloidal esicacileyo okanye esine-turbid kancinane, kwaye ayinakunyibilika kakubi kwizinyibilikisi zezinto eziphilayo.
2. I-Viscosity
I-Viscosity yenye yezona zibonakaliso ezibalulekileyo zezobugcisa ze-HPMC, ezimisela ukusebenza kwe-AnxinCel®HPMC kwizicelo ezahlukeneyo. I-viscosity ye-HPMC ilinganiswa ngokubanzi njenge-2% yesisombululo se-aqueous kwi-20 ° C, kwaye uluhlu oluqhelekileyo lwe-viscosity lusuka kwi-5 mPa · ukuya kwi-200,000 mPa · s. Iphezulu i-viscosity, inamandla ngakumbi isiphumo sokuqina kwesisombululo kwaye ingcono i-rheology. Xa isetyenziswe kumashishini afana nokwakhiwa kunye neyeza, ibakala elifanelekileyo le-viscosity kufuneka likhethwe ngokweemfuno ezithile.
3. IMethoxy kunye neHydroxypropoxy Content
Iimpawu zeekhemikhali ze-HPMC zichongwa kakhulu yi-methoxy (-OCH₃) kunye ne-hydroxypropoxy (-OCH₂CHOHCH₃) idigri zokutshintsha. I-HPMC enezidanga ezahlukeneyo zokubeka endaweni ibonisa ukunyibilika okwahlukileyo, umsebenzi womphezulu kunye nobushushu be-gelation.
Umxholo we-Methoxy: Ngokuqhelekileyo phakathi kwe-19.0% kunye ne-30.0%.
Umxholo weHydroxypropoxy: Ngokuqhelekileyo phakathi kwe-4.0% kunye ne-12.0%.
4. Umxholo wokufuma
Umxholo wokufuma we-HPMC ulawulwa ngokubanzi kwi-≤5.0%. Isiqulatho esiphakamileyo sokufuma siya kuchaphazela uzinzo kunye nokusetyenziswa kwesiphumo semveliso.
5. Umxholo wothuthu
Umlotha yintsalela emva kokuba i-HPMC itshisiwe, ubukhulu becala kwiityuwa ezingaphiliyo ezisetyenziswa kwinkqubo yemveliso. Umxholo womlotha udla ngokulawulwa kwi-≤1.0%. Isiqulatho sothuthu esiphezulu kakhulu sinokuchaphazela ukungafihli kunye nokucoceka kwe-HPMC.
6. Ukunyibilika kunye nokungafihli
I-HPMC ine-solubility efanelekileyo yamanzi kwaye inokunyibilika ngokukhawuleza emanzini abandayo ukwenza isisombululo esifanayo se-colloidal. Ukucaca kwesisombululo kuxhomekeke ekucocekeni kwe-HPMC kunye nenkqubo yokuchithwa kwayo. Isisombululo se-HPMC esikumgangatho ophezulu sikholisa ukucaca okanye sibisi kancinci.
7. Ubushushu beGel
Isisombululo samanzi se-HPMC siya kwenza ijeli kubushushu obuthile. Ukushisa kwayo kwe-gel ngokuqhelekileyo phakathi kwe-50 kunye ne-90 ° C, kuxhomekeke kumxholo we-methoxy kunye ne-hydroxypropoxy. I-HPMC enomxholo ophantsi we-methoxy inobushushu bejeli ephezulu, ngelixa i-HPMC enomxholo ophezulu we-hydroxypropoxy inobushushu obuphantsi bejeli.
8. ixabiso le-pH
Ixabiso le-pH ye-AnxinCel®HPMC isisombululo samanzi ngokuqhelekileyo phakathi kwe-5.0 kunye ne-8.0, engathathi hlangothi okanye i-alkaline engenamandla kwaye ifanelekile kwiindawo ezahlukeneyo zesicelo.
9. Ubungakanani besuntswana
Ukulunga kwe-HPMC kubonakaliswa ngokubanzi njengepesenti edlula kwi-80-mesh okanye i-100-mesh screen. Ngokuqhelekileyo kufunwa ukuba ≥98% idlule kwisikrini se-80-mesh ukuqinisekisa ukuba inokusabalalisa okulungileyo kunye ne-solubility xa isetyenziswa.
10. Umxholo wentsimbi enzima
Umxholo wentsimbi enzima (efana nelothe kunye ne-arsenic) ye-HPMC kufuneka ihambelane nemigangatho yoshishino efanelekileyo. Ngokuqhelekileyo, umxholo okhokelayo ngu-≤10 ppm kwaye umxholo we-arsenic ngu-≤3 ppm. Ngokukodwa kwibakala lokutya kunye neyeza le-HPMC, iimfuno zesiqulatho sentsimbi enzima zingqongqo.
11. Iimpawu ezincinci
Kwibakala lamayeza kunye nokutya i-AnxinCel®HPMC, ukungcoliseka kwe-microbial kufuneka kulawulwe, kubandakanywa inani elipheleleyo lekholoni, ukungunda, igwele, i-E. coli, njl., edla ngokufuna:
Ubalo lwekholoni iyonke ≤1000 CFU/g
Inani lokungunda kunye negwele lilonke ≤100 CFU / g
I-E. coli, i-Salmonella, njl
12. Iindawo zesicelo eziphambili
I-HPMC isetyenziswa ngokubanzi kumashishini amaninzi ngenxa yokuqina kwayo, ukugcinwa kwamanzi, ukwenza ifilimu, ukuthambisa, ukumilisela kunye nezinye iimpawu:
Umzi-mveliso wokwakha: Njenge-ejenti yokuqina kunye nokugcinwa kwamanzi kwi-samente yodaka, i-putty powder, i-adhesive tile, kunye ne-coating engenamanzi ukuphucula umsebenzi wokwakha.
Umzi-mveliso wamachiza: Isetyenziswa njengento yokuncamathelisa, ehlala ikhutshwa, kunye neqokobhe le-capsule imathiriyeli ekrwada kwiipilisi zamachiza.
Ishishini lokutya: lisetyenziswa njenge-emulsifier, i-stabilizer, i-thickener, isetyenziswa kwijeli, iziselo, izinto ezibhakiweyo, njl.
Ishishini lemihla ngemihla lemichiza: isetyenziswa njenge-thickener kunye ne-emulsifier stabilizer kwiimveliso zokhathalelo lwesikhumba, izicoci, kunye neeshampu.
Iimpawu zobugcisa zeHPMCzibandakanya i-viscosity, i-degree of substitution (umxholo weqela le-hydrolyzed), umswakama, umxholo womlotha, ixabiso le-pH, ubushushu be-gel, ubuhle, umxholo wensimbi enzima, njl. Ezi zalathi zinquma ukusebenza kwayo kwesicelo kwiinkalo ezahlukeneyo. Xa ukhetha i-HPMC, abasebenzisi kufuneka bamisele iinkcukacha ezifanelekileyo ngokweemfuno ezithile zesicelo ukuqinisekisa eyona mpembelelo yokusetyenziswa.
Ixesha lokuposa: Feb-11-2025