Zeziphi iintlobo ezahlukeneyo zeHPMC?

IHydroxypropyl Methylcellulose (HPMC) yipolymer eguquguqukayo esetyenziswa kumashishini ahlukeneyo kubandakanya amayeza, ulwakhiwo, ukutya, kunye nezithambiso. Ithathwe kwi-cellulose, i-polymer yendalo efumaneka kwizityalo. I-HPMC ixatyiswa ngokubanzi ngokwenza ifilim, ukutyeba, ukuzinzisa, kunye neempawu zokugcina amanzi. Kwishishini loxubo mayeza, lisetyenziswa ngokuqhelekileyo njengeyeza leyeza kwiifom zedosi yomlomo, amalungiselelo e-ophthalmic, imixube yamachiza, kunye neenkqubo zokuhanjiswa kweziyobisi ezilawulwayo.

I-HPMC ingahlelwa ngokusekelwe kwiiparamitha ezininzi ezibandakanya ubunzima bayo bemolekyuli, iqondo lokutshintshwa, kunye nobukhulu bamasuntswana. Nantsi isishwankathelo seentlobo ezahlukeneyo ze-HPMC esekwe kwezi parameters:

Ngokusekwe kubunzima beMolekyuli:

High Molecular Weight HPMC: Olu hlobo lwe-HPMC lunobunzima obuphezulu be-molecular, obukhokelela ekuphuculeni i-viscosity kunye neempawu zokwenza ifilimu. Ihlala ikhethwa kwizicelo apho i-viscosity ephezulu ifunekayo, njengakwimiqulu elawulwayo yokukhutshwa.

Ubunzima beMolekyuli obuphantsi HPMC: Ngokuchaseneyo, ubunzima bemolekyuli ephantsi i-HPMC ine-viscosity esezantsi kwaye isetyenziswa kwizicelo apho i-viscosity esezantsi kunye nokuchithwa ngokukhawuleza kufunwa.

Ngokusekelwe kwiSidanga sokuTshintsha (DS):

I-High Substitution HPMC (HPMC-HS): I-HPMC eneqondo eliphezulu lokutshintshwa ngokuqhelekileyo ibonisa ukunyibilika okungcono emanzini kwaye inokusetyenziswa kwimixube efuna ukuchithwa ngokukhawuleza.

Medium Substitution HPMC (HPMC-MS): Olu hlobo HPMC inika ibhalansi phakathi solubility kunye viscosity. Isetyenziswa ngokuqhelekileyo kwiintlobo ezahlukeneyo zamachiza.

I-Low Substitution HPMC (HPMC-LS): I-HPMC eneqondo elisezantsi lokutshintshwa ibonelela ngamazinga okuchithwa okucothayo kunye ne-viscosity ephezulu. Isoloko isetyenziswa kwiifom zedosi yokukhutshwa okuzinzileyo.

Ngokusekwe kubungakanani beNcam:

I-Fine Particle Size HPMC: I-HPMC enesayizi encinci yamasuntswana ibonelela ngeempawu zokuqukuqela ezingcono kwaye ihlala ikhethwa kwiifomu zedosi eqinileyo efana neetafile kunye neecapsules.

I-Coarse Particle Ubungakanani be-HPMC: Amasuntswana angama-Coarser afanelekile kwizicelo apho ukukhutshwa okulawulwayo okanye iipropati zokukhutshwa okwandisiweyo zifunwa. Ngokuqhelekileyo zisetyenziswa kwiipilisi ze-matrix kunye neepelisi.

AmaBanga awodwa:

I-Enteric HPMC: Olu hlobo lwe-HPMC lwenzelwe ngokukodwa ukuxhathisa ulwelo lwe-gastric, luyivumela ukuba idlule esiswini kwaye ikhulule iyeza emathunjini. Iqhele ukusetyenziselwa amachiza anovelwano kwi-pH yesisu okanye unikezelo ekujoliswe kulo.

Ukukhutshwa okuZinzileyo kwe-HPMC: Le mixube iyilelwe ukukhulula isithako esisebenzayo ngokuthe ngcembe kwithuba elongeziweyo, okukhokelela kwisenzo sechiza ixesha elide kunye nokuncipha kwe-dosing frequency. Zihlala zisetyenziswa kwiimeko ezingapheliyo apho ukugcina amanqanaba eziyobisi rhoqo egazini kubalulekile.

Amabanga adityanisiweyo:

I-HPMC-Acetate Succinate (HPMC-AS): Olu hlobo lwe-HPMC ludibanisa iipropati ze-HPMC kunye namaqela e-acetyl, okwenza ukuba ilungele ukugquma kwe-enteric kunye neenkqubo zokuhanjiswa kweziyobisi ezithintekayo nge-pH.

I-HPMC-Phthalate (HPMC-P): I-HPMC-P i-polymer exhomekeke kwi-pH edla ngokusetyenziswa kwiingubo ze-enteric ukukhusela ichiza kwiimeko ze-acidic esiswini.

Imixube eyenzelwe wena:

Abavelisi banokudala imidibaniso elungiselelweyo ye-HPMC kunye nezinye iipholima okanye abancedisi ukufikelela kwiimfuno ezithile zokuyila ezifana neeprofayili eziphuculweyo zokukhupha ichiza, uzinzo olongeziweyo, okanye iimpawu ezingcono zokufihla incasa.

iipropathi ezahlukahlukeneyo ze-HPMC zivumela ukusetyenziswa kwayo kuluhlu olubanzi lokuqulunqwa kwamayeza, nganye ilungiselelwe ukuhlangabezana neemfuno ezithile ezifana nokunyibilika, i-viscosity, i-kinetics yokukhulula, kunye nokuzinza. Ukuqonda iindidi ezahlukeneyo ze-HPMC kunye neempawu zazo kubalulekile kubaqulunqi bayile iinkqubo ezisebenzayo neziphuculweyo zokuhanjiswa kwamachiza.