Zeziphi izicelo zeselulosi kwishishini lamayeza?

I-Cellulose, enye yezona zixhobo zininzi zezinto eziphilayo emhlabeni, ifumana ukusetyenziswa okubanzi kumashishini ahlukeneyo ngenxa yeempawu zayo ezizodwa. Kwishishini lamayeza, i-cellulose kunye nezinto eziphuma kuyo zidlala indima ebalulekileyo kwiinkqubo zokuhanjiswa kweziyobisi, ukwakhiwa kweepilisi, ukubopha amanxeba, nokunye.

1. Isibophelelo kwiiNdlela zeThebhile:

I-cellulose derivatives efana ne-microcrystalline cellulose (MCC) kunye ne-powdered cellulose isebenza njengezibophelelo ezisebenzayo kwi-tablet formulations. Baphucula ukubambisana kunye namandla omatshini amacwecwe, ukuqinisekisa ukuhanjiswa kweziyobisi ezifanayo kunye neeprofayili zokukhululwa okuhambelanayo.

2. I-Disintegrant:

I-cellulose ephuma kwi-cellulose efana ne-croscarmellose sodium kunye ne-sodium carboxymethyl cellulose (NaCMC) zisebenza njenge-disintegrants kwiipilisi, ziququzelela ukuphuka ngokukhawuleza kwe-tablet matrix xa idibene nolwelo olumanzi. Le propati yongeza ukuchithwa kwechiza kunye ne-bioavailability.

3. Iinkqubo eziLawulwayo zokuhanjiswa kweziyobisi:

I-cellulose derivatives zizinto ezibalulekileyo kwiifomyula ezikhutshwayo ezilawulwayo. Ngokuguqula ulwakhiwo lweekhemikhali okanye ubungakanani besuntswana leselulosi, ukugcinwa, ukwandiswa, okanye iiprofayili zokukhutshwa kweziyobisi ezijoliswe kuzo zinokufezekiswa. Oku kuvumela ukuhanjiswa kwechiza okongezelelekileyo, ukunciphisa ukuphindaphindwa kwedosi, kunye nokuphuculwa kokuthotyelwa kwesigulana.

4. Izinto zokugquma:

I-cellulose derivatives efana ne-ethyl cellulose kunye ne-hydroxypropyl methylcellulose (HPMC) zisetyenziswa ngokuqhelekileyo njengeengubo zefilimu kwiipilisi kunye neegranules. Babonelela ngomqobo okhuselayo, bagqume incasa engathandekiyo, balawule ukukhutshwa kweziyobisi, kwaye baphucule uzinzo.

5. I-arhente yokutyebisa kunye nokuzinzisa:

Iellulosi ethers ezifana ne-HPMC kunye ne-sodium carboxymethyl cellulose zisetyenziswa njengee-arhente ezityebisayo nezizinzisayo kwiifom zedosi yolwelo ezifana nokunqunyanyiswa, i-emulsions, kunye neesyrups. Baphucula i-viscosity, banqande intlenga, kwaye baqinisekise ukuhanjiswa kweziyobisi ezifanayo.

6. Umxhasi kwiiFowulation zeMixholo:

Kwimixube yezihloko ezifana neekhrimu, i-ointments, kunye neegels, izinto eziphuma kwi cellulose zisebenza njenge viscosity modifiers, emulsifiers, and stabilizers. Banikezela ngeempawu ezinqwenelekayo ze-rheological, baphucula ukusasazeka, kwaye bakhuthaze ukunamathela eluswini okanye kwimifinya.

7. Izinxibo zamanxeba:

Izinto ezisekelwe kwi-cellulose, kuquka i-cellulose ene-oxidized kunye ne-carboxymethyl cellulose, zisetyenziselwa ukubopha amanxeba ngenxa ye-hemostatic, i-absorbent, kunye ne-antimicrobial properties. Ezi zinxibo zikhuthaza ukuphiliswa kwenxeba, zithintele usulelo, kwaye zigcine imeko-bume yamanxeba efumileyo.

8. Isikafula kubuNjineli beTissue:

I-Cellulose scaffolds ibonelela nge-biocompatible kunye ne-biodegradable matrix kwizicelo zobunjineli bezicubu. Ngokubandakanya i-bioactive agents okanye iiseli, i-scaffolds esekwe kwi-cellulose inokuxhasa ukuvuselelwa kwezicubu kunye nokulungiswa kwiimeko ezahlukeneyo zonyango.

9. Ukwenziwa kweCapsule:

I-cellulose derivatives efana ne-hypromellose kunye ne-hydroxypropyl cellulose zisetyenziswa njengezixhobo ze-capsule-forming, ezinikezela ngenye indlela kwii-capsules ze-gelatin. Ii-capsules ezisekelwe kwi-cellulose zifanelekile kuzo zombini iifomyula zangoku kunye nokuguqulwa kokukhululwa kwaye zikhethwa kwimifuno okanye izithintelo zezenkolo.

10. Umthwali kwiiNkqubo zokuSasazwa okuSolid:

I-cellulose nanoparticles ifumene ingqwalasela njengabathwali beziyobisi ezinganyibilikiyo emanzini kwiinkqubo eziqinileyo zokusasazeka. Indawo yabo ephezulu, i-porosity, kunye ne-biocompatibility iququzelela ukupheliswa kwechiza okuphuculweyo kunye ne-bioavailability.

11. Izicelo ezichasene nenkohliso:

Izinto ezisekelwe kwi-cellulose zingabandakanywa kwi-package yamachiza njengemilinganiselo yokuchasana ne-counterfeiting. Iithegi ezisekelwe kwi-cellulose okanye iilebhile ezineempawu zokhuseleko ezifakwe ngaphakathi zinokunceda ukuqinisekiswa kweemveliso zoxubo kunye nokuthintela abazenzisi.

12. Ukuhanjiswa kweziyobisi zokuphefumla:

I-cellulose ephuma kwi-cellulose efana ne-microcrystalline cellulose kunye ne-lactose zisetyenziswa njengabathwali bemiqulu eyomileyo yokuphefumla umgubo. Aba bathwali baqinisekisa ukusasazwa okufanayo kweziyobisi kunye nokuququzelela ukuhanjiswa okusebenzayo kwindlela yokuphefumula.

i-cellulose kunye nezinto eziphuma kuyo zisebenza njengezinto ezininzi ezincedisayo kunye nemathiriyeli kwishishini loxubo-mayeza, igalelo kuphuhliso lweemveliso zamachiza ezikhuselekileyo, ezisebenzayo, nezilungele isigulane. Iipropati zabo ezikhethekileyo zenza uluhlu olubanzi lwezicelo, ukusuka kwi-tablet formulations ukuya ekunyamekelweni kwenxeba kunye nobunjineli bezicubu, okwenza i-cellulose ibe yinto efunekayo ekuqulunqweni kwamayeza kunye nezixhobo zonyango.