IHydroxypropyl Methylcellulose (HPMC)yipolima enyibilikayo emanzini edla ngokusetyenziswa kwimizi-mveliso yamayeza, ezozithambiso kunye nokutya. Ngenxa yokunyibilika kwamanzi okugqwesileyo kunye neempawu zohlengahlengiso lwe-viscosity, i-HPMC isetyenziswa ngokubanzi kwiijeli, iifom zedosi elawulwa ngamachiza, ukunqunyanyiswa, i-thickeners kunye nezinye iindawo. Iintlobo ezahlukeneyo kunye neenkcukacha ze-HPMC zinemigangatho eyahlukeneyo yobushushu, ngakumbi xa ulungiselela iijeli ze-HPMC, ubushushu bunempembelelo ebalulekileyo kwi-solubility yayo, i-viscosity kunye nokuzinza.
Ukuchithwa kwe-HPMC kunye nohlobo lobushushu bokwenza ijeli
Ubushushu bokupheliswa
I-HPMC idla ngokuchithwa emanzini ngamanzi ashushu, kwaye ubushushu bokutshatyalaliswa buxhomekeke kubunzima bayo be-molecular kunye neqondo le-methylation kunye ne-hydroxypropylation. Ngokuqhelekileyo, iqondo lokushisa lokuchithwa kwe-HPMC livela kwi-70 ° C ukuya kwi-90 ° C, kunye nokushisa okuthe tye kokuchithwa kuchaphazeleka kwiinkcukacha ze-HPMC kunye nokugxininiswa kwesisombululo. Ngokomzekelo, i-low-viscosity HPMC idla ngokuchithwa kwiqondo lokushisa elisezantsi (malunga ne-70 ° C), ngelixa i-high-viscosity HPMC inokufuna ukushisa okuphezulu (kufuphi ne-90 ° C) ukuchithwa ngokupheleleyo.
Ubushushu boBume beGel (iTemperature yeGelation)
I-HPMC inepropati ekhethekileyo yejeli ye-thermoreversible, oko kukuthi, iya kwenza ijeli ngaphakathi koluhlu oluthile lobushushu. Uluhlu lobushushu lwejeli ye-HPMC ichaphazeleka kakhulu bubunzima bayo bemolekyuli, ubume beekhemikhali, ukugxininiswa kwesisombululo kunye nezinye izongezo. Xa sithetha ngokubanzi, uluhlu lobushushu bejeli ye-HPMC ludla ngokuba ngama-35°C ukuya kuma-60°C. Ngaphakathi kolu luhlu, i-HPMC yamatsheyina eemolekyuli iya kuphinda ilungelelanise ukwenza isakhiwo sothungelwano esine-dimensional-dimensional network, ebangela ukuba isisombululo sitshintshe ukusuka kwimeko yolwelo ukuya kwi-gel state.
Ubushushu obuthile bokwakheka kwejeli (oko kukuthi, iqondo lobushushu lejeli) inokumiselwa ngokomfuniselo. Ubushushu bejeli ye-HPMC buxhomekeke kwezi zinto zilandelayo:
Ubunzima bemolekyuli: I-HPMC enobunzima obuphezulu bemolekyuli inokwenza ijeli kwiqondo lobushushu elisezantsi.
Ukugxininiswa kwesisombululo: Ukuphakama koxinzelelo lwesisombululo, iqondo lokushisa elisezantsi le-gel liqhelekileyo.
I-Degree ye-methylation kunye neqondo le-hydroxypropylation: I-HPMC enezinga eliphezulu le-methylation idla ngokwenza ijeli kwiqondo lokushisa eliphantsi kuba i-methylation yandisa intsebenziswano phakathi kwee-molecule.
Isiphumo sobushushu
Kwizicelo ezisebenzayo, ubushushu bunempembelelo enkulu ekusebenzeni kunye nokuzinza kwejeli ye-HPMC. Amaqondo obushushu aphezulu kwandisa fluidity of HPMC amatyathanga molekyuli, ngaloo ndlela echaphazela ubungqongqo kunye neempawu ukunyibilika ijeli. Ngokuchasene noko, ubushushu obuphantsi bunokwenza buthathaka ijeli ye-HPMC kwaye yenze ulwakhiwo lwejeli lungazinzi. Ukongeza, utshintsho lwamaqondo obushushu lunokubangela intsebenziswano phakathi kweemolekyuli zeHPMC kunye notshintsho kwi-viscosity yesisombululo.
Ukuziphatha kwe-HPMC gelation kwi-pH eyahlukileyo kunye namandla e-ionic
Ukuziphatha kwe-gelation ye-HPMC ayichatshazelwa kuphela ngubushushu, kodwa kunye ne-pH kunye namandla e-ionic yesisombululo. Umzekelo, ukunyibilika kunye nokuziphatha kwe-gelation ye-HPMC kumaxabiso ahlukeneyo e-pH kuya kwahluka. Ukunyibilika kwe-HPMC kunokuncitshiswa kwiindawo ezineasidi, ngelixa ukunyibilika kwayo kunokonyuka kwiindawo ezine-alkaline. Ngokufanayo, ukwanda kwamandla e-ionic (njengokongezwa kweetyuwa) kuya kuchaphazela ukusebenzisana phakathi kwama-molecule e-HPMC, ngaloo ndlela kutshintshe ukubunjwa kunye nokuzinza kwe-gel.
Ukusetyenziswa kwejeli ye-HPMC kunye neempawu zayo zobushushu
Iimpawu zobushushu bejeli ye-HPMC zenza ukuba isetyenziswe ngokubanzi ekukhululweni kweziyobisi, ukulungiselela izithambiso kunye neminye imimandla:
Ukukhutshwa kweziyobisi okulawulwayo
Kumalungiselelo eziyobisi, i-HPMC isoloko isetyenziswa njenge-matrix yokukhululwa elawulwayo, kunye neempawu zayo ze-gelation zisetyenziselwa ukulawula izinga lokukhululwa kwamachiza. Ngokulungelelanisa iqondo lokushisa kunye ne-gelation ye-HPMC, ukukhutshwa kwamachiza kunokulawulwa ngokuchanekileyo. Ukutshintsha kobushushu bamachiza kwindlela yesisu kunokukhuthaza ukudumba kwejeli yeHPMC kunye nokukhululwa ngokuthe ngcembe kwamachiza.
Izithambiso kunye neeMveliso zoNakekelo loMntu
I-HPMC idla ngokusetyenziswa kwizinto zokuthambisa ezifana nokuthambisa, iijeli, izitshizi zeenwele, kunye nezithambiso zolusu. Ngenxa yobuntununtunu beqondo lobushushu, i-HPMC inokulungelelanisa ukuthungwa kunye nokuzinza kweemveliso phantsi kweemeko ezahlukeneyo zobushushu. Utshintsho lobushushu kwiindlela zokuthambisa zinefuthe elibalulekileyo kwindlela yokuziphatha ye-gelation ye-HPMC, ngoko ke imilinganiselo efanelekileyo ye-HPMC kufuneka ikhethwe ngononophelo xa kuyilwa iimveliso.
Ishishini lokutya
Ekutyeni, i-HPMC isetyenziswa ngokubanzi njenge-thickener kunye ne-emulsifier, ngakumbi ekutyeni okulungele ukutyiwa kunye neziselo. Iimpawu zayo ezingevayo kubushushu zenza ukuba i-HPMC itshintshe isimo sayo somzimba ngexesha lokufudumeza okanye ukupholisa, ngaloo ndlela ichaphazela incasa kunye nokwakheka kokutya.
Iimpawu zobushushu zeHPMCiigels ziyinto ephambili kwisicelo sabo. Ngokulungelelanisa ubushushu, ugxininiso, kunye nokuguqulwa kweekhemikhali, iipropati ze-HPMC gels, ezifana ne-solubility, amandla e-gel, kunye nokuzinza, zinokulawulwa ngokuchanekileyo. Ubushushu bokwakheka kwejeli buqhele ukuba phakathi kwama-35°C kunye nama-60°C, ngelixa ubushushu bokunyibilika buyi-70°C ukuya kuma-90°C. I-HPMC isetyenziswa ngokubanzi kumashishini amayeza, ezozithambiso, kunye nokutya ngenxa yokuziphatha kwayo kwe-thermoreversible gelation eyodwa kunye novakalelo lobushushu.
Ixesha lokuposa: Jan-16-2025