IHydroxypropyl Methylcellulose (HPMC)yikhompawundi yepolymer enyibilikayo emanzini efunyenwe ngokuguqula imichiza yendalo iselulosi. Isetyenziswa ikakhulu kumasimi amayeza, ukutya, izinto zokuthambisa, kunye nokwakha, kwaye ineepropathi ezigqwesileyo ezinje ngokuqina, ukwenza ifilimu, ukumiliselwa, kunye nokuzinza.
1. Umgaqo wokulungiselela
IHydroxypropyl methylcellulose yi-hydrophilic cellulose derivative, kwaye ukunyibilika kwayo kuchaphazeleka ikakhulu yi-hydroxypropyl kunye ne-methyl substituents kwi-molecule. Iqela le-methyl liyakwandisa ukunyibilika kwamanzi, ngelixa iqela le-hydroxypropyl linyusa izinga lokuchithwa kwamanzi. Ngokubanzi, i-AnxinCel®HPMC inokunyibilika ngokukhawuleza kumanzi abandayo ukwenza isisombululo se-colloidal esifanayo, kodwa inyibilika ngokukhawuleza emanzini ashushu, kwaye izinto ze-granular zixhomekeke ekuhlanganiseni ngexesha lokuchithwa. Ngoko ke, ingqalelo kufuneka ihlawulwe ekulawuleni ukushisa kokutshatyalaliswa kunye nenkqubo yokutshatyalaliswa ngexesha lokulungiselela.
2. Ukulungiselela imathiriyeli ekrwada
I-HPMC powder: Khetha i-HPMC powder kunye ne-viscosities eyahlukeneyo kunye needigri zokutshintshwa ngokweemfuno zokusetyenziswa. Iimodeli eziqhelekileyo ziquka i-viscosity ephantsi (i-molecular weight low) kunye ne-viscosity ephezulu (i-molecular weight). Ukhetho kufuneka lusekelwe kwiimfuno zoyilo oluthile.
I-Solvent: Amanzi sesona sinyibilikisi sisetyenziswa kakhulu, ngakumbi ekusetyenzisweni kwamayeza kunye nokutya. Ngokweemfuno zokuchithwa, umxube wamanzi kunye ne-organic solvents, njenge-ethanol / amanzi axutywe isisombululo, nawo angasetyenziswa.
3. Indlela yokulungiselela
Ubunzima HPMC
Okokuqala, ukulinganisa ngokuchanekileyo i-HPMC powder efunekayo ngokuhambelana nesisombululo sokulungiswa. Ngokuqhelekileyo, uluhlu loxinaniso lwe-HPMC luyi-0.5% ukuya kwi-10%, kodwa ugxininiso oluthile kufuneka luhlengahlengiswe ngokwenjongo kunye ne-viscosity efunekayo.
Ukunyibilika kwangaphambili kokumanzisa
Ukuze kuthintelwe i-HPMC powder kwi-agglomerating, ukuchithwa kwangaphambili kwe-wetting ngokuqhelekileyo kwamkelwa. Umsebenzi othile: ufefe umgubo we-HPMC olinganisiweyo ngokulinganayo kwinxalenye ye-solvent, ugxobhoze ngobunono, kwaye wenze uqhagamshelwano lwe-HPMC lomgubo kunye nexabiso elincinci le-solvent kuqala ukwenza isimo esimanzi. Oku kunokuthintela ngokufanelekileyo i-HPMC powder kwi-agglomerating kwaye ikhuthaze ukusabalalisa kwayo okufanayo.
Inkqubo yokupheliswa
Yongeza kancinane i-solvent eseleyo kumgubo we-HPMC omanzi kwaye uqhubeke uvuselela. Ekubeni i-HPMC ine-solubility efanelekileyo yamanzi, amanzi kunye ne-HPMC zinyibilika ngokukhawuleza kwiqondo lokushisa. Gwema ukusebenzisa i-shear force ephezulu kakhulu xa uvuselela, kuba ukuvuselela okunamandla kuya kubangela ukuba amaqamza enze amaqamza, achaphazela ukungafihli kunye nokufana kwesisombululo. Ngokuqhelekileyo, isantya esishukumisayo kufuneka sigcinwe kwindawo ephantsi ukuze kuqinisekiswe ukuchithwa okufanayo.
Ulawulo lobushushu
Nangona i-HPMC inokunyibilika emanzini abandayo, ukuba izinga lokuchithwa licotha, isisombululo sinokufudumeza ngokufanelekileyo. Ubushushu bokufudumala kufuneka bulawulwe phakathi kwe-40 ° C kunye ne-50 ° C ukuphepha ukushisa okugqithisileyo okubangela utshintsho kwisakhiwo se-molecular okanye utshintsho olubukhali kwi-viscosity yesisombululo. Ngexesha lenkqubo yokufudumeza, ukuvuselela kufuneka kuqhutywe de i-HPMC ichithwe ngokupheleleyo.
Ukupholisa kunye nokuhluzwa
Emva kokupheliswa okupheleleyo, vumela isisombululo ukuba sipholile ngokwemvelo kwiqondo lokushisa. Ngethuba lenkqubo yokupholisa, inani elincinci leebhubhu okanye ukungcola kunokuvela kwisisombululo. Ukuba kukho imfuneko, isihluzi singasetyenziselwa ukusihluza ukususa amasuntswana aqinileyo anokwenzeka kwaye kuqinisekiswe ukucaca kunye nokungafihli kwesisombululo.
Uhlengahlengiso lokugqibela kunye nokugcinwa
Emva kokuba isisombululo sipholile, ukugxilwa kwayo kunokulungiswa ngokweemfuno zangempela. Ukuba i-concentration iphezulu kakhulu, i-solvent inokongezwa ukuyihlambulula; ukuba ugxininiso luphantsi kakhulu, ngaphezulu kwe-HPMC powder kufuneka yongezwe. Emva kokuba isisombululo silungisiwe, kufuneka sisetyenziswe ngokukhawuleza. Ukuba kufuneka igcinwe ixesha elide, kufuneka igcinwe kwisikhongozeli esivaliweyo ukunqanda ukuphuphuma kwamanzi okanye ukungcoliseka kwesisombululo.
4. Izilumkiso
Ukulawula ubushushu: Ukushisa okuphezulu kufuneka kugwenywe ngexesha lokuchithwa ukuphepha ukuchaphazela ukunyibilika kunye nokusebenza kwe-AnxinCel®HPMC. Kubushushu obuphezulu, i-HPMC inokuthoba okanye i-viscosity yayo iyancipha, ichaphazela ukusebenza kwayo.
Indlela yokuvuselela: Kuthintele ukucheba okugqithisileyo okanye isantya esikhawulezileyo sokushukumisa, kuba ukushukuma okunamandla kunokubangela ukuba amaqamza enze amaqamza kwaye kuchaphazele ukungafihli kwesisombululo.
Ukukhethwa kwe-solvent: Amanzi awona manzi asetyenziswa ngokuqhelekileyo, kodwa kwezinye izicelo ezikhethekileyo, isisombululo esixubileyo samanzi kunye nezinye i-solvents (ezifana notywala, i-acetone, njl.) inokukhethwa. Imilinganiselo eyahlukeneyo ye-solvent iya kuchaphazela izinga lokuchithwa kunye nokusebenza kwesisombululo.
Iimeko zokugcina: Isisombululo se-HPMC esilungisiweyo kufuneka sigcinwe kwindawo epholileyo neyomileyo ukuphepha ukubonakaliswa kwexesha elide kwiqondo lokushisa eliphezulu okanye ilanga elithe ngqo ukukhusela utshintsho kumgangatho wesisombululo.
I-Anti-caking: Xa i-powder yongezwa kwi-solvent, ukuba i-powder yongezwa ngokukhawuleza okanye ngokungalingani, kulula ukwenza izibonda, ngoko kufuneka ifakwe ngokuthe ngcembe.
5. Iinkalo zesicelo
IHydroxypropyl methylcellulose isetyenziswa kakhulu kumashishini ahlukeneyo ngenxa yokunyibilika kwayo okugqwesileyo kwamanzi kunye ne-biocompatibility:
Umzi-mveliso wamachiza: Njengefilimu yangaphambili, i-adhesive, thickener, i-ejenti yokukhululwa okuqhubekayo, njl.
Ishishini lokutya: Njenge-thickener, emulsifier, stabilizer, lihlala lisetyenziswa ekusetyenzweni kokutya, okufana ne-ayisikrimu, i-condiments, iziselo, njl.
Umzi-mveliso wokwakha: Njenge-thickener yokwaleka kwezakhiwo kunye nodaka, inokuphucula ukunamathela kunye nolwelo lomxube.
Izithambiso: Njengokuqina, ukuzinzisa kunye nefilimu yangaphambili, isetyenziswa kwizinto zokuthambisa ezifana neekhrimu, iishampu, kunye neemveliso zokhathalelo lwesikhumba ukuphucula umgangatho wemveliso kunye namava omsebenzisi.
Ulungiselelo lweHPMCyinkqubo efuna ingqalelo kwiinkcukacha. Ngethuba lenkqubo yokulungiselela, izinto ezifana nokushisa, indlela yokuvuselela, kunye nokukhethwa kwe-solvent kufuneka ilawulwe ukuqinisekisa ukuba inokuchithwa ngokupheleleyo kwaye igcine ukusebenza kakuhle. Ngendlela echanekileyo yokulungiselela, i-AnxinCel®HPMC ingasetyenziswa ngokubanzi kumashishini amaninzi kwaye idlala indima ebalulekileyo.
Ixesha lokuposa: Jan-16-2025