IHydroxypropyl methylcellulose-HPMC

IHydroxypropyl methylcellulose (HPMC)yikhompawundi eguquguqukayo enoluhlu olubanzi lwezicelo kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa, ulwakhiwo, nokunye.

Ubume beMichiza kunye noLwakhiwo:
I-HPMC yi-semi-synthetic, inert, i-viscoelastic polymer ephuma kwi-cellulose ngokuguqulwa kweekhemikhali. Iqulethwe ngamayunithi aphindaphindiweyo eemolekyuli ze-glucose, ezifana ne-cellulose, kunye ne-hydroxypropyl eyongezelelweyo kunye namaqela e-methyl aqhotyoshelwe kwi-cellulose backbone. Iqondo lokuthatha indawo (DS) la maqela limisela iimpawu ze-HPMC, kubandakanywa ukunyibilika, i-viscosity, kunye nokuziphatha kwe-gelation.

Inkqubo yokuVelisa:
Udibaniso lwe-HPMC lubandakanya amanyathelo amaninzi. Ekuqaleni, i-cellulose iphathwa nge-alkali ukwenza amaqela e-hydroxyl asebenze. Emva koko, ipropylene oxide iphendulwa kunye neselulosi esebenzayo ukwazisa amaqela e-hydroxypropyl. Okokugqibela, i-methyl chloride isetyenziselwa ukuncamathisela amaqela e-methyl kwi-hydroxypropylated cellulose, ekhokelela ekusekweni kwe-HPMC. I-DS ye-hydroxypropyl kunye namaqela e-methyl inokulawulwa ngexesha lenkqubo yokuvelisa ukulungelelanisa iimpawu ze-HPMC kwizicelo ezithile.

Iinkcazelo Ngeempawu:
I-HPMC ngumgubo omhlophe ukuya kumhlophe kunye nokunyibilika okugqwesileyo kwamanzi. Iyanyibilika kumanzi abandayo kunye nashushu, yenze izisombululo ezicacileyo, ezibonakala. I-viscosity yezisombululo ze-HPMC ixhomekeke kwizinto ezifana nobunzima bemolekyuli, iqondo lokuthatha indawo, kunye noxinzelelo. Ukongeza, i-HPMC ibonisa ukuziphatha kwe-pseudoplastic, okuthetha ukuba i-viscosity yayo iyancipha phantsi koxinzelelo lwe-chear, iyenza ilungele izicelo ezifana ne-agent e-thickening, i-stabilizers, kunye nabasunguli befilimu.

Usetyenziso:
Amachiza:HPMCisetyenziswa ngokubanzi kwimiqulu yeyeza njenge-binder, ifilimu yangaphambili, i-disintegrant, kunye ne-ejenti ekhutshwayo elawulwayo kwiipilisi, ii-capsules, kunye ne-topical formulations. Ubume bayo obungangeni, ukuhambelana nezithako ezisebenzayo zamachiza (APIs), kunye nokukwazi ukuguqula i-kinetics yokukhupha ichiza kwenza kube yinto ebalulekileyo kwiinkqubo zokuhanjiswa kweziyobisi.

Ishishini lokutya: Kushishino lokutya, i-HPMC isetyenziswa njenge-thickener, emulsifier, stabilizer, kunye ne-gelling agent kwiimveliso ezahlukeneyo ezifana neesosi, izinxibo, izimuncumuncu, kunye nezinto zokubhaka. Iphucula ukuthungwa, iphucula umlomo, kwaye inika uzinzo kwimixube yokutya ngaphandle kokuguqula incasa okanye ivumba.

Izithambiso: I-HPMC idityaniswe kwimixube yezithambiso njengefilimu yangaphambili, ijitshi, kunye nearhente yokuxhoma kwiikhrimu, izinto zokuthambisa, iishampu, kunye nezinye iimveliso zokhathalelo lomntu. Inika i-viscosity, iphucula ukusasazeka, kwaye iphucula uzinzo lwemveliso ngelixa ihambisa izibonelelo zokuthambisa kunye nemeko eluswini nasezinweleni.

Umzi-mveliso wokwakha: Kushishino lokwakha, i-HPMC isetyenziswa njengento etyebisayo, i-arhente yokugcina amanzi, kunye nesixhasi sokusebenza kudaka olusekwe kwisamente, izinto zokuncamathelisa iithayile, udaka, kunye neegrouts. Iphucula ukusebenza kakuhle, ukunciphisa ukwahlula kwamanzi, kunye nokwandisa ukunamathela, okubangelwa izinto zokwakha ezihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala zihlala khona.

Ezinye ii-Aplikheshini: I-HPMC ifumana usetyenziso kwiindawo ezahlukeneyo ezinjengoshicilelo olulukiweyo, iiseramikhi, ukwenziwa kwepeyinti, kunye neemveliso zolimo. Isebenza njenge-ejenti yokuqina, i-rheology modifier, kunye ne-binder kwezi zicelo, igalelo ekusebenzeni kwemveliso kunye nomgangatho.

IHydroxypropyl methylcellulose (HPMC)yipolymer enemisebenzi emininzi enezicelo ezixhaphakileyo kumashishini ahlukeneyo ngenxa yendibaniselwano eyodwa yeepropathi, kubandakanya ukunyibilika kwamanzi, ukulawulwa kwe-viscosity, isakhono sokwenza ifilimu, kunye ne-biocompatibility. Ukuguquguquka kwayo kunye nokuhambelana nezinto ezahlukeneyo kuyenza ibe sisithako esiyimfuneko kumayeza, iimveliso zokutya, izinto zokuthambisa, kunye nezinto zokwakha, phakathi kwezinye. Njengoko uphando kunye nenkqubela phambili yetekhnoloji iqhubeka, ukusetyenziswa kwe-HPMC kulindeleke ukuba kwandiswe ngakumbi, ukuqhuba ukuqamba izinto ezintsha kunye nokuphucula ukusebenza kwemveliso kumacandelo awohlukeneyo.