Ubushushu bejeli yeHydroxypropyl methylcellulose

IHydroxypropyl methylcellulose (HPMC)yipolymer eguquguqukayo esetyenziswa ngokubanzi kuqulunqo lwamayeza, iimveliso zokutya, izinto zokuthambisa, kunye nokusetyenziswa kwemizi-mveliso. I-HPMC ixatyiswe ngokukwazi ukwenza iijeli, iifilimu, kunye nokunyibilika kwayo emanzini. Nangona kunjalo, ubushushu be-gelation ye-HPMC bunokuba yinto ebalulekileyo ekusebenzeni kwayo kunye nokusebenza kwizicelo ezahlukeneyo. Imiba enxulumene nobushushu obufana nobushushu be-gelation, utshintsho lwe-viscosity, kunye nokuziphatha kokunyibilika kunokuchaphazela ukusebenza kunye nokuzinza kwemveliso yokugqibela.

Ukuqonda iHydroxypropyl Methylcellulose (HPMC)

IHydroxypropyl methylcellulose yimveliso yecellulose apho amanye amaqela e-hydroxyl e-cellulose atshintshwa nge-hydroxypropyl kunye namaqela e-methyl. Olu hlengahlengiso luphucula ukunyibilika kwepolymer emanzini kwaye kubonelela ngolawulo olungcono kwi-gelation kunye neempawu ze-viscosity. Ubume bepolymer bunika amandla okwenza iigels xa kwizisombululo ezinamanzi, okwenza kube yinto ekhethiweyo kumashishini ahlukeneyo.

I-HPMC inepropati ekhethekileyo: idlula i-gelation kumaqondo obushushu athile xa inyibilika emanzini. Ukuziphatha kwe-gelation ye-HPMC kuphenjelelwa zizinto ezifana nobunzima be-molecular, i-degree of substitution (DS) ye-hydroxypropyl kunye namaqela e-methyl, kunye nokuxinwa kwe-polymer kwisisombululo.

Gelation lobushushu of HPMC

Ubushushu beGelation bubhekisa kwiqondo lobushushu apho i-HPMC ingena kwinguqu yesigaba ukusuka kulwelo ukuya kwimeko yejeli. Le yiparamitha ebalulekileyo kwimixube eyahlukeneyo, ngakumbi kwimveliso yamayeza kunye nezithambiso apho ukuhambelana okuchanekileyo kunye nokuthungwa kuyadingeka.

Ukuziphatha kwe-gelation ye-HPMC ngokuqhelekileyo kubonakaliswa ngubushushu obubalulekileyo be-gelation (CGT). Xa isisombululo sifudumala, i-polymer idibana nokusebenzisana kwe-hydrophobic eyenza ukuba idibanise kwaye yenze i-gel. Nangona kunjalo, iqondo lokushisa apho oku kwenzeka khona kunokwahluka ngokusekelwe kwizinto ezininzi:

Ubunzima beMolekyuli: Ubunzima obuphezulu bemolekyuli iHPMC yenza iijeli kumaqondo obushushu aphezulu. Ngokuchaseneyo, ubunzima obusezantsi bemolekyuli i-HPMC idla ngokubumba iijeli kumaqondo obushushu asezantsi.

Isidanga soTshintsho (DS): Iqondo lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methyl inokuchaphazela ukunyibilika kunye nobushushu be-gelation. Iqondo eliphezulu lokutshintsha (amaqela amaninzi e-methyl okanye e-hydroxypropyl) ngokuqhelekileyo lehlisa iqondo lobushushu le-gelation, lenze i-polymer inyibilike ngakumbi kwaye iphendule kutshintsho lobushushu.

Ukugxila: Uxinzelelo oluphezulu lwe-HPMC emanzini lunokunciphisa ubushushu be-gelation, njengoko umxholo wepolymer owandisiweyo uququzelela ukusebenzisana ngakumbi phakathi kwamaketanga e-polymer, ukukhuthaza ukubunjwa kwe-gel kwiqondo lokushisa eliphantsi.

Ubukho beeIons: Kwizisombululo ezinamanzi, ii-ion zinokuchaphazela ukuziphatha kwe-gelation ye-HPMC. Ubukho beetyuwa okanye ezinye i-electrolytes zinokutshintsha ukusebenzisana kwepolymer ngamanzi, okuchaphazela ukushisa kwayo kwe-gelation. Ngokomzekelo, ukongezwa kwe-sodium chloride okanye iityuwa ze-potassium kunokunciphisa ukushisa kwe-gelation ngokunciphisa i-hydration ye-polymer chain.

pH: I-pH yesisombululo inokuchaphazela nokuziphatha kwe-gelation. Ekubeni i-HPMC ingathathi hlangothi phantsi kweemeko ezininzi, utshintsho lwe-pH ludla ngokuba nesiphumo esincinci, kodwa amanqanaba aphezulu e-pH anokubangela ukuthotywa okanye ukuguqula iimpawu ze-gelation.

Iingxaki zobushushu kwi-HPMC Gelation

Imiba emininzi enxulumene nobushushu inokwenzeka ngexesha lokuqulunqwa kunye nokusetyenzwa kweegels ezisekelwe kwi-HPMC:

1. IGelation yangaphambi kwexesha

I-gelation yangaphambi kwexesha iyenzeka xa i-polymer iqala ukuhlamba kwiqondo lokushisa eliphantsi kunokuba lifunwa, okwenza kube nzima ukusetyenzwa okanye ukudibanisa kwimveliso. Lo mbandela unokuvela ukuba ubushushu be-gelation busondele kakhulu kubushushu be-ambient okanye ubushushu bokusebenza.

Ngokomzekelo, ekuveliseni i-gel okanye i-cream ye-pharmaceutical, ukuba isisombululo se-HPMC siqala i-gel ngexesha lokuxuba okanye ukuzaliswa, kunokubangela ukuvinjelwa, ukuthungwa okungahambelaniyo, okanye ukuqina okungafunekiyo. Oku kuyingxaki ngokukodwa kwimveliso enkulu, apho ulawulo oluchanekileyo lweqondo lokushisa luyimfuneko.

2. IGelation engaphelelanga

Ngakolunye uhlangothi, i-gelation engaphelelanga iyenzeka xa i-polymer ingenalo i-gel njengoko kulindelwe kwiqondo lokushisa elifunwayo, okubangelwa imveliso ye-runny okanye ephantsi-viscosity. Oku kunokwenzeka ngenxa yokuqulunqwa okungalunganga kwesisombululo se-polymer (njengokugxininiswa okungalunganga okanye ubunzima obungafanelekanga be-molecular HPMC) okanye ukulawulwa kobushushu obunganelanga ngexesha lokucubungula. I-gelation engaphelelanga idla ngokubonwa xa i-polymer concentration iphantsi kakhulu, okanye isisombululo asifikeleli kwiqondo lokushisa elifunekayo ixesha elaneleyo.

3. Ukungazinzi kweThermal

Ukungazinzi kwe-Thermal kubhekiselele ekuqhekekeni okanye ekuthotyweni kwe-HPMC phantsi kweemeko eziphezulu zokushisa. Ngelixa i-HPMC izinzile, ukuvezwa ixesha elide kumaqondo obushushu aphezulu kunokubangela i-hydrolysis yepolymer, ukunciphisa ubunzima bayo bemolekyuli kwaye, ngenxa yoko, isakhono sayo se-gelation. Oku kuthotywa kwe-thermal kukhokelela kwisakhiwo se-gel esibuthathaka kunye noshintsho kwiimpawu ezibonakalayo ze-gel, ezifana ne-viscosity ephantsi.

4. Ukuguquguquka kweViscosity

Ukuguquguquka kweViscosity ngomnye umngeni onokuthi wenzeke ngeejeli zeHPMC. Ukuhluka kobushushu ngexesha lokucubungula okanye ukugcinwa kunokubangela ukuguquguquka kwe-viscosity, okukhokelela kumgangatho wemveliso ongahambelaniyo. Umzekelo, xa igcinwe kumaqondo obushushu aphakamileyo, ijeli inokuba bhityile kakhulu okanye ityebe kakhulu ngokuxhomekeke kwiimeko zobushushu obuphantsi kwayo. Ukugcina ubushushu bokusebenza obuhambelanayo kubalulekile ukuze kuqinisekiswe i-viscosity ezinzileyo.

Itheyibhile: Impembelelo yoBubushushu kwiiPropati ze-HPMC Gelation

Izisombululo zokujongana neeNgxaki eziNxulumene noBubushushu

Ukuthomalalisa iingxaki ezinxulumene nobushushu kwimixube yejeli ye-HPMC, ezi zicwangciso-qhinga zilandelayo zingasetyenziswa:

Lungiselela Ubunzima beMolekyuli kunye neDegree yokuTshintsha: Ukukhetha ubunzima bemolekyuli obufanelekileyo kunye neqondo lokutshintshwa kwesicelo esicetywayo kunokunceda ukuqinisekisa ukuba ukushisa kwe-gelation kuphakathi koluhlu olufunwayo. Lower molekyuli ubunzima HPMC ingasetyenziswa ukuba iqondo lobushushu elisezantsi gelation kufuneka.

Lawula Ukugxila: Ukulungelelanisa ukugxininiswa kwe-HPMC kwisisombululo kunokunceda ukulawula ukushisa kwe-gelation. Ugxininiso oluphezulu lukhuthaza ukubunjwa kwejeli kumaqondo aphantsi.

Ukusetyenziswa koLungiso oluLawulwayo loBubushushu: Kwimveliso, ukulawula ukushisa okuchanekileyo kubalulekile ukukhusela i-gelation yangaphambi kwexesha okanye engaphelelanga. Iinkqubo zokulawula ubushushu, njengamatanki okuxuba ashushu kunye neenkqubo zokupholisa, zinokuqinisekisa iziphumo ezihambelanayo.

Dibanisa iziZinzisi kunye nezinyibilikisi: Ukongezwa kwe-stabilizers okanye i-co-solvents, njenge-glycerol okanye i-polyols, inokunceda ukuphucula ukuzinza kwe-thermal ye-HPMC kunye nokunciphisa ukuguquguquka kwe-viscosity.

Ukubeka iliso kwi-pH kunye namandla e-Ionic: Kubalulekile ukulawula i-pH kunye namandla e-ionic yesisombululo ukuthintela utshintsho olungafunekiyo kwindlela yokuziphatha kwe-gelation. Inkqubo yesithinteli inokunceda ukugcina iimeko ezifanelekileyo zokwakheka kwejeli.

Imiba enxulumene nobushushu obunxulumene neHPMCiigels zibalulekile ukujongana nokuphumeza ukusebenza kakuhle kwemveliso, nokuba yeyeyeza, i-cosmetic, okanye izicelo zokutya. Ukuqonda izinto ezichaphazela ubushushu be-gelation, njengobunzima bemolekyuli, ugxininiso, kunye nobukho beeyoni, kubalulekile ekuqulunqweni okuyimpumelelo kunye neenkqubo zokuvelisa. Ukulawulwa ngokufanelekileyo kobushushu bokusebenza kunye neeparamitha zokuqulunqa kunokunceda ukunciphisa iingxaki ezifana ne-gelation ngaphambi kwexesha, i-gelation engaphelelanga, kunye nokuguquguquka kwe-viscosity, ukuqinisekisa ukuzinza kunye nokusebenza kakuhle kweemveliso ezisekelwe kwi-HPMC.