IHydroxypropyl methyl cellulose HPMC, eyaziwa ngokuba yi-hydroxypromellose, i-white to white cellulose ether powder okanye i-granule ene-solubility yamanzi abandayo kunye nokungabikho kwamanzi ashushu afana ne-methyl cellulose. Iqela le-Hydroxypropyl kunye neqela le-methyl yi-ether bond kunye ne-anhydrous glucose ring ye-cellulose edibeneyo, luhlobo lwe-non-ionic cellulose exutywe i-ether. Yi-semi-synthetic, engasebenziyo, i-viscoelastic polymer edla ngokusetyenziswa njenge-lubricant kwi-ophthalmology, okanye njenge-excipient okanye i-excipient kumayeza omlomo.
1. Inkqubo yemveliso
I-Kraft pulp enomxholo we-αcellulose we-97%, i-viscosity yangaphakathi ye-720mL / g kunye ne-fiber ephakathi ubude be-2.6mm ifakwe kwi-49% isisombululo se-NaOH kwi-40 ℃ imizuzwana ye-50. Emva koko i-pulp yakhutshwa ukuze isuse isisombululo se-49% se-NaOH esingaphezulu ukufumana i-alkali cellulose. Umlinganiselo wobunzima (i-49% ye-NaOH isisombululo se-aqueous) ukuya (icandelo eliqinileyo le-pulp) kwinqanaba lokungena liyi-200. Umlinganiselo wesisindo se-NaOH kwi-cellulose ye-alkali ukuya kwi-pulp eqinile yi-1.49. I-alkali cellulose efunyenweyo (20kg) ifakwe kwi-jacked pressure reactor kunye nokuphazamiseka kwangaphakathi, emva koko icociwe kwaye ihlanjululwe nge-nitrogen ukuze isuse ngokwaneleyo i-oksijini kwi-reactor. Emva koko, iqondo lobushushu kwi-reactor lalilawulwa kwi-60 ℃ ngelixa ukuvuselela kwangaphakathi kuqhutywe.
Emva koko i-2.4kg dME yongezwa kwaye ubushushu kwi-reactor yalawulwa ukuya kwi-60℃. Emva kokongezwa kwe-dimethyl ether, i-methylene chloride yongezwa ukwenza umlinganiselo we-molar ye-methylene chloride kwi-NaOH kwi-alkaline cellulose 1.3, i-propylene oxide yongezwa ukwenza umlinganiselo wobunzima be-propylene oxide kwi-pulp 1.97, kwaye ubushushu kwi-reactor bulawulwa ukusuka kwi-80℃ ukuya kwi-60℃. Emva kokongeza ikloromethane kunye nepropylene oxide, iqondo lobushushu kwireactor lalawulwa ukusuka kwi-80℃ ukuya kuma-90℃. Ukongeza, ukusabela kuthathe imizuzu engama-20 kwi-90 ℃.
Irhasi ke iye ikhutshwe kwireactor kwaye ikrwada yehydroxypropyl methyl cellulose iyasuswa kwireactor. Ubushushu be-hydroxypropyl methyl cellulose yayingama-62℃. Ukulinganisa i-50% yobungakanani bamasuntswana kubunzima obongezelekayo obusekwe kubungakanani bobungakanani bamasuntswana ngokusekwe kumyinge we-hydroxypropyl methyl cellulose ngokuvuleka kwezihluzo ezintlanu, nganye inesayizi yokuvula eyahlukileyo.
Ngenxa yoko, i-avareji yobungakanani bamasuntswana arhabaxa yayiyi-6.2mm. I-hydroxypropyl methyl cellulose ekrwada efunyenweyo yaziswa kwi-biaxial kneader eqhubekayo (KRC kneader S1, L / D = 10.2, umthamo wangaphakathi we-0.12 L, isantya sokujikeleza i-150rpm) ngesantya se-10kg / hr, kunye ne-crude ekrwada efunyenwe i-hydroxypropyl methyl cellulose. Njengomphumo wemilinganiselo efanayo usebenzisa izikrini ezi-5 ezinobukhulu obuhlukeneyo bokuvula, ubungakanani be-particle ye-particle yayiyi-1.4mm. Yongeza i-80℃ yamanzi ashushu kwi-crude hydroxypropyl methyl cellulose etankini ngolawulo lobushushu bebhatyi. ubungakanani bobunzima bomlinganiselo we-hydroxypropyl methyl cellulose ebolileyo kwixabiso elipheleleyo le-slurry yi-0.1, kwaye i-slurry ifunyenwe. I-slurry yashukunyiswa kwiqondo lokushisa elingaguqukiyo le-80 ℃ imizuzu engama-60.
Emva koko, i-slurry inikezelwa kwisantya esijikelezayo se-0.5 RPM kunye ne-pre-heated rotary pressure filter (imveliso ye-BHS Sonthofen). Ubushushu begrout yi 93℃. Sebenzisa impompo ukubonelela nge-slurry, uxinzelelo lokukhupha impompo yi-0.2mpa. Ubungakanani bokuvula i-rotary pressure filter yi-80μm, kwaye indawo yokucoca yi-0.12m2. I-slurry enikezelwe kwisihluzi soxinzelelo lwe-rotary ihluzwa ngesihluzo kwaye iguqulelwe kwikhekhe lokucoca. Ikeyiki yokucoca isiphumo ibonelelwa nge-0.3mpa yomphunga kunye ne-95℃ yamanzi ashushu kunye nomlinganiselo wobunzima be-10.0 ukuya kwindawo eqinileyo ye-HYDROXYpropyl methyl cellulose ehlanjiweyo, ethi ke ihluzwe ngesihluzo.
Amanzi ashushu anikezelwa ngempompo kuxinzelelo lokukhupha lwe-0.2mpa. Emva kokuba kunikezelwe ngamanzi ashushu, i-0.3mpa umphunga unikezelwa. Emva koko, emva kokuhlamba iimveliso zisuswe kwindawo yokucoca nge-scraper kwaye zikhutshwe kumatshini wokuhlamba. Amanyathelo ukusuka ekunikezeni i-slurry ukukhupha iimveliso ezihlanjiweyo ziqhutyelwa ngokuqhubekayo. Njengoko kulinganiswa kusetyenziswa i-hygrometer yokushisa, umthamo wamanzi wemveliso ehlanjiweyo ukhutshiwe yi-52.8%. Iimveliso ezihlanjiweyo ezikhutshiweyo kwisihluzo soxinzelelo olujikelezayo zomiswa ngesisomisi somoya kwi-80℃, zaze zatyunyuzwa kwi-Vill Mill ukuze kufumaneke i-hydroxypropyl methyl cellulose.
2.Isicelo
HPMCimveliso isetyenziswa njenge thickener, dispersant, binder, emulsifier kunye nokuzinzisa kushishino olulukiweyo. Ikwasetyenziswa ngokubanzi kwi-synthetic resin, i-petrochemical, i-ceramic, iphepha, isikhumba, amayeza, ukutya, izinto zokuthambisa kunye namanye amashishini.
Ixesha lokuposa: Apr-26-2024