Uyisebenzisa njani i-hydroxypropyl methylcellulose kunye nezilumkiso

1. Intshayelelo kwi-hydroxypropyl methylcellulose

IHydroxypropyl methylcellulose (HPMC)yi-ether ye-cellulose engeyo-ionic eyenziwe kwizinto zendalo ze-polymer ngokuguqulwa kweekhemikhali. Isetyenziswa kakhulu kulwakhiwo, amayeza, ukutya, izithambiso, iingubo kunye nezinye iindawo, kwaye inemisebenzi emininzi efana nokujiya, ukugcinwa kwamanzi, ukwenziwa kwefilimu, kunye nokuncamathela.

2. Indlela yokusebenzisa i-hydroxypropyl methylcellulose

Ukunyibilika kwamanzi abandayo
I-AnxinCel®HPMC inokusasazwa ngokuthe ngqo kumanzi abandayo, kodwa ngenxa ye-hydrophilicity yayo, kulula ukwenza amaqhuma. Kucetyiswa ukuba ufefe ngokucothayo HPMC kumanzi abandayo avuselelwe ukuze kuqinisekiswe ukusasazwa okufanayo kwaye unqande i-agglomeration.

Ukutshatyalaliswa kwamanzi ashushu
Emva kokumanzisa kwangaphambili HPMC ngamanzi ashushu, yongeza amanzi abandayo ukudumba ukwenza isisombululo efanayo. Le ndlela ifanelekile kwi-HPMC ephezulu ye-viscosity.

Ukuxuba umgubo owomileyo
Ngaphambi kokusebenzisa i-HPMC, inokuxutywa ngokulinganayo kunye nezinye izinto zomgubo ekrwada, ize ixutywe kwaye inyibilikiswe ngamanzi.

Ishishini lokwakha
Kwi-mortar kunye ne-putty powder, inani elongezelelweyo le-HPMC liyi-0.1% ~ 0.5% ngokubanzi, esetyenziselwa kakhulu ukuphucula ukugcinwa kwamanzi, ukusebenza kokwakhiwa kunye nokusebenza okuchasayo.

Ishishini lamachiza
I-HPMC isoloko isetyenziswa kwi-tablet yokwaleka kunye ne-matrix yokukhululwa okuqhubekayo, kwaye umthamo wayo kufuneka ulungelelaniswe ngokwefomula ethile.

Ishishini lokutya
Xa isetyenziswe njenge-thickener okanye i-emulsifier ekutyeni, idosi kufuneka ihambelane nemigangatho yokhuseleko lokutya, ngokubanzi i-0.1% ~ 1%.

Iingubo
Xa i-HPMC isetyenziswa kwi-coatings esekwe emanzini, inokuphucula ukutyeba kunye ne-dispersibility ye-coating kwaye ithintele imvula ye-pigment.

Izithambiso
I-HPMC isetyenziselwa ukuzinzisa kwizinto zokuthambisa ukuze kuphuculwe ukubamba kunye ne-ductility yemveliso.

3. Izilumkiso zokusebenzisa i-hydroxypropyl methylcellulose

Ixesha lokuchithwa kunye nokulawula ubushushu
I-HPMC ithatha ixesha elithile ukunyibilika, ngokuqhelekileyo imizuzu engama-30 ukuya kwiiyure ezi-2. Ukushisa okuphezulu kakhulu okanye okuphantsi kakhulu kuya kuchaphazela izinga lokuchithwa, kwaye ubushushu obufanelekileyo kunye neemeko zokuvuselela kufuneka zikhethwe ngokwemeko ethile.

Kuphephe ukungqubana
Xa ufaka i-HPMC, kufuneka isasazwe ngokucothayo kwaye ishukunyiswe ngokucokisekileyo ukuthintela i-agglomeration. Ukuba i-agglomeration iyenzeka, kufuneka ishiywe yodwa kangangexesha elithile kwaye ishukunyiswe emva kokuba idumbile ngokupheleleyo.

Impembelelo yokufuma kokusingqongileyo
I-HPMC inovelwano kukufuma kwaye ithanda ukufunxa ukufuma kunye ne-agglomeration kwindawo yokufuma okuphezulu. Ngoko ke, ingqalelo kufuneka ihlawulwe kukomisa kwendawo yokugcina kwaye ukupakishwa kufuneka kutywinwe.

Ukumelana ne-Acid kunye ne-alkali
I-HPMC izinzile ngokwentelekiso kwiiasidi kunye neealkali, kodwa isenokuthomalalisa kwindawo eneasidi eyomeleleyo okanye yealkali, echaphazela ukusebenza kwayo. Ngoko ke, iimeko ezigqithisileyo ze-pH kufuneka zigwenywe kangangoko kunokwenzeka ngexesha lokusetyenziswa. 

Ukukhetha iimodeli ezahlukeneyo
I-HPMC ineentlobo ngeentlobo zeemodeli (ezifana ne-viscosity ephezulu, i-viscosity ephantsi, ukunyibilika ngokukhawuleza, njl.), kunye nokusebenza kunye nokusetyenziswa kwazo kuyahluka. Xa ukhetha, imodeli efanelekileyo kufuneka ikhethwe ngokwemeko ethile yesicelo (njengezinto zokwakha, amayeza, njl.) kunye neemfuno.

Ucoceko nokhuseleko
Xa usebenzisa i-AnxinCel®HPMC, izixhobo zokukhusela kufuneka zinxitywe ukuphepha ukuphefumla uthuli.

Xa isetyenziselwa ukutya kunye namayeza, kufuneka ihambelane nemimiselo kunye nemigangatho yoshishino olufanelekileyo.

Ukuhambelana nezinye izongezo

Xa ixutywe nezinye izinto kwifomula, ingqalelo kufuneka ihlawulwe ukuhambelana kwayo ukuphepha imvula, i-coagulation okanye ezinye iimpendulo ezimbi.

4. Ukugcinwa kunye nokuthutha

Ugcino
HPMCkufuneka igcinwe kwindawo epholileyo, eyomileyo, ukuphepha ukushisa okuphezulu kunye nokufuma. Iimveliso ezingasetyenziswanga kufuneka zitywinwe.

Ezothutho
Ngexesha lokuthutha, kufuneka ikhuselwe emvuleni, umswakama kunye nokushisa okuphezulu ukuphepha umonakalo kwipakethe.

I-Hydroxypropyl methylcellulose yimathiriyeli yeekhemikhali eziguquguqukayo ezifuna ukuchithwa kwesayensi kunye nengqiqo, ukongezwa kunye nokugcinwa kwizicelo eziphathekayo. Nika ingqalelo ukuphepha i-agglomeration, ukulawula iimeko zokuchithwa, kwaye ukhethe imodeli efanelekileyo kunye nedosi ngokweemeko ezahlukeneyo zesicelo ukwandisa ukusebenza kwayo. Kwangaxeshanye, imigangatho yoshishino kufuneka ilandelwe ngokungqongqo ukuqinisekisa usetyenziso olukhuselekileyo nolusebenzayo lweHPMC.