1. Iimpawu ezisisiseko ze-HPMC
IHydroxypropyl methylcellulose (HPMC)yi-ether ye-cellulose ye-nonionic esetyenziswa ngokubanzi kwizinto zokwakha, amayeza, ukutya, izimonyo kunye namanye amashishini. Iimpawu zayo ezikhethekileyo ze-physicochemical, ezifana ne-solubility, i-thickening, i-film-forming kunye ne-thermal gelation properties, yenza ukuba ibe yinto ephambili kwizicelo ezininzi zoshishino. Iqondo lobushushu yenye yezinto eziphambili ezichaphazela ukusebenza kwe-HPMC, ngakumbi ngokubhekiselele kwi-solubility, i-viscosity, i-thermal gelation kunye nokuzinza kwe-thermal.
2. Impembelelo yobushushu kwi-solubility ye-HPMC
HPMC yi polima thermoreversibly enyibilikayo, kwaye ukunyibilika kwayo utshintsho kunye lobushushu:
Imeko yobushushu obuphantsi (amanzi abandayo): I-HPMC inyibilika ngokulula emanzini abandayo, kodwa iyakufunxa amanzi kwaye idumbe xa idibana namanzi kuqala ukwenza amasuntswana ejeli. Ukuba ukuvuselela akwanelanga, amaqhuma anokwenza. Ke ngoko, kuyacetyiswa ukuba wongeze i-HPMC kancinci ngelixa uvuselela ukukhuthaza ukusasazwa okufanayo.
Ubushushu obuphakathi (20-40℃): Kolu luhlu lobushushu, i-HPMC inonyibiliko oluhle kunye ne-viscosity ephezulu, kwaye ifanelekile kwiinkqubo ezahlukeneyo ezifuna ukutyeba okanye ukuzinzisa.
Ubushushu obuphezulu (ngaphezu kwama-60°C): I-HPMC ithanda ukwenza ijeli eshushu kubushushu obuphezulu. Xa iqondo lokushisa lifikelela kwiqondo elithile le-gel, isisombululo siya kuba yi-opaque okanye sidibanise, sichaphazela umphumo wesicelo. Ngokomzekelo, kwizinto zokwakha ezifana nodaka okanye i-putty powder, ukuba ukushisa kwamanzi kuphezulu kakhulu, i-HPMC ayinakuchithwa ngokufanelekileyo, ngaloo ndlela ichaphazela umgangatho wokwakha.
3. Impembelelo yobushushu kwi-HPMC viscosity
I-viscosity ye-HPMC ichatshazelwa kakhulu bubushushu:
Ukwandisa ubushushu, ukunciphisa i-viscosity: I-viscosity yesisombululo se-HPMC ngokuqhelekileyo iyancipha ngokunyuka kobushushu. Ngokomzekelo, i-viscosity yesisombululo esithile se-HPMC ingaba phezulu kwi-20 ° C, ngelixa i-50 ° C, i-viscosity yayo iya kuhla kakhulu.
Ubushushu buyancipha, i-viscosity iphinda ibuyele: Ukuba isisombululo se-HPMC sipholile emva kokufudumeza, i-viscosity yayo iya kubuya ngokuyinxenye, kodwa ayinakukwazi ukubuyela ngokupheleleyo kwimeko yokuqala.
I-HPMC yamabanga ahlukeneyo e-viscosity iziphatha ngendlela eyahlukileyo: i-high-viscosity HPMC inovakalelo ngakumbi kutshintsho lobushushu, ngelixa i-low-viscosity HPMC inokuguquguquka kwe-viscosity encinci xa ubushushu butshintsha. Ngoko ke, kubaluleke kakhulu ukukhetha i-HPMC kunye ne-viscosity efanelekileyo kwiimeko ezahlukeneyo zesicelo.
4. Impembelelo yobushushu kwi-thermal gelation ye-HPMC
Uphawu olubalulekileyo lwe-HPMC yi-gelation ye-thermal, oko kukuthi, xa izinga lokushisa likhuphuka kwinqanaba elithile, isisombululo salo siya kujika sibe yi-gel. Eli qondo lobushushu lidla ngokubizwa ngokuba bubushushu be-gelation. Iindidi ezahlukeneyo ze-HPMC zinamaqondo obushushu ahlukeneyo e-gelation, ngokubanzi phakathi kwe-50-80℃.
Kumashishini okutya kunye namayeza, olu phawu lwe-HPMC lusetyenziselwa ukulungiselela amayeza akhutshwa ngokuzinzileyo okanye i-colloids yokutya.
Kwizicelo zokwakha, ezifana nodaka lwesamente kunye ne-putty powder, i-thermal gelation ye-HPMC inokubonelela ngokugcinwa kwamanzi, kodwa ukuba ubushushu bendawo yokwakha buphezulu kakhulu, i-gelation inokuchaphazela umsebenzi wokwakha.
5. Impembelelo yeqondo lokushisa kwi-thermal stability ye-HPMC
Ulwakhiwo lwekhemikhali ye-HPMC luzinzile kuluhlu lobushushu obufanelekileyo, kodwa ukuba sesichengeni sexesha elide kubushushu obuphezulu kunokubangela ukuthotywa.
Iqondo lobushushu lexesha elifutshane (elifana nokufudumeza ngoko nangoko ukuya ngaphezulu kwe-100℃): ayinakuchaphazeli kakhulu iipropathi zekhemikhali ze-HPMC, kodwa inokubangela utshintsho kwiimpawu zomzimba, ezifana nokuncipha kwe-viscosity.
Ubushushu bexesha elide eliphezulu (elifana nokufudumeza okuqhubekekayo ngaphezulu kwe-90℃): kunokubangela ukuba ikhonkco lemolekyuli ye-HPMC yaphuke, kubangele ukuhla okungenakujikwa kwi-viscosity, okuchaphazela ukujiya kwayo kunye neempawu zokwenza ifilim.
Ubushushu obugqithisileyo obuphezulu (ngaphezu kwe-200℃): I-HPMC isenokubola, ikhuphe izinto eziguqukayo ezifana ne-methanol kunye ne-propanol, kwaye ibangele imathiriyeli ukuba ibe nombala okanye i-carbonize.
6. Iingcebiso zesicelo se-HPMC kwiindawo ezahlukeneyo zokushisa
Ukuze unike umdlalo opheleleyo ekusebenzeni kwe-HPMC, amanyathelo afanelekileyo kufuneka athathwe ngokwemeko ezahlukeneyo zobushushu:
Kwimeko yobushushu obuphantsi (0-10℃): I-HPMC inyibilika kancinane, kwaye kuyacetyiswa ukuba iyinyibilikise kwangaphambili emanzini ashushu (20-40℃) phambi kokusetyenziswa.
Kwimekobume yobushushu obuqhelekileyo (10-40℃): I-HPMC inomsebenzi ozinzile kwaye ilungele uninzi lwezicelo, ezinje ngezogquma, iifama, ukutya kunye nezinto ezincedisa amayeza.
Kwimeko yobushushu obuphezulu (ngaphezulu kwe 40℃): Kuphephe ukongeza iHPMC ngokuthe ngqo kulwelo lobushushu obuphezulu. Kucetyiswa ukuba inyibilike emanzini abandayo ngaphambi kokuyifudumeza, okanye ukhethe i-HPMC echasene nobushushu obuphezulu ukunciphisa impembelelo ye-thermal gelation kwisicelo.
Ubushushu bunefuthe elibalulekileyo kwi-solubility, viscosity, i-thermal gelation kunye nokuzinza kwe-thermal.HPMC. Ngethuba lenkqubo yesicelo, kuyimfuneko ukukhetha ngokufanelekileyo imodeli kunye nendlela yokusetyenziswa kwe-HPMC ngokwemiqathango ethile yokushisa ukuqinisekisa ukusebenza kwayo okulungileyo. Ukuqonda uvakalelo lobushushu be-HPMC akunakuphucula kuphela umgangatho wemveliso, kodwa kwakhona ukuphepha ilahleko engeyomfuneko ebangelwa utshintsho lobushushu kunye nokuphucula ukusebenza kakuhle kwemveliso kunye neenzuzo zoqoqosho.
Ixesha lokuposa: Mar-28-2025