HPMC hydroxypropyl methylcelluloseibe yenye yezona excipients zamachiza ekhaya nakwamanye amazwe, kuba HPMC ineengenelo ukuba ezinye excipients abanazo.
1. Ukunyibilika kwamanzi
Iyanyibilika kumanzi abandayo angaphantsi kwe-40 ℃ okanye i-70% ye-ethanol, kwaye ayinyibiliki emanzini ashushu angaphezu kwama-60 ℃, kodwa iyakwazi ukukhutshwa.
2. Inert ngokwekhemikhali
I-HPMC luhlobo lwe-ether ye-cellulose engeyiyo ionic. Isisombululo sayo asithwali i-ionic intlawulo kwaye ayisebenzi kunye neetyuwa zetsimbi okanye i-ionic organic compounds. Ngoko ke, abanye abancedisi abaphenduli kunye nayo ngexesha lenkqubo yokulungiselela.
3. Ukuzinza
Izinzile kwi-asidi kunye ne-alkali, kwaye inokugcinwa ixesha elide phakathi kwe-pH 3 ~ 11, kwaye i-viscosity yayo ayinalo utshintsho olucacileyo. Isisombululo se-aqueous se-HPMC sinomphumela wokulwa ne-mildew kwaye sinokugcina uzinzo oluhle lwe-viscosity ngexesha lokugcinwa kwexesha elide. Abaxumi bamayeza abasebenzisayoHPMCbabe nozinzo olungcono lomgangatho kunabo basebenzisa izixhobo zemveli (ezifana ne-dextrin, istatshi, njl.).
4. Ukulungelelaniswa kwe-viscosity
I-viscosity derivatives eyahlukeneyo ye-HPMC inokuxutywa ngokwemilinganiselo eyahlukeneyo, kwaye i-viscosity yayo inokutshintsha ngokomgaqo othile, kwaye inobudlelwane obuhle bomgca, ngoko inokukhethwa ngokwemfuno. 2.5 I-Metabolic inertia I-HPMC ayixutywanga okanye i-metabolized emzimbeni, kwaye ayiboneleli ngeekhalori, ngoko ke i-excipient ekhuselekileyo kumalungiselelo amayeza. .
5. Ukhuseleko
Ngokuqhelekileyo kuqwalaselwa ukubaHPMCayiyotyhefu kwaye ayicaphukisi.
I-HPMC ye-Pharmaceutical-grade yimathiriyeli ekrwada ebalulekileyo kwimveliso yamalungiselelo okukhululwa azinzileyo nalawulwayo. Yinto encedisa amayeza exhaswa ngurhulumente kuphando nophuhliso, kwaye ihambelana nesikhokelo sophuhliso esixhaswa ngumgaqo-nkqubo wesizwe wezoshishino. I-Pharmaceutical-grade HPMC yeyona nto iphambili ekuvelisweni kwee-capsules zezityalo ze-HPMC, ezibalelwa ngaphezu kwe-90% yezinto ezikrwada zee-capsules zezityalo ze-HPMC. Iipilisi zezityalo eziveliswayo zineenzuzo zokhuseleko kunye nococeko, ukusetyenziswa okubanzi, akukho mngcipheko wokuphendula ukudibanisa, kunye nokuzinza okuphezulu, okuhambelana nokulindela kwabathengi. Iimfuno zokhuseleko kunye nococeko lokutya kunye namayeza yenye yezongezo ezibalulekileyo kunye neemveliso ezifanelekileyo endaweni yeepilisi zegelatin yezilwanyana.
Ixesha lokuposa: Apr-25-2024