Hydroxypropyl methylcellulose (HPMC)ke sesebelisoa sa polymer se qhibilihang ka metsi se sebelisoang haholo ho tsa meriana, kaho, lijo, litlolo le masimo a mang. Thepa ea eona ea viscosity ke parameter ea bohlokoa ho lekanya boitšoaro ba eona ba rheological tlas'a maemo a fapaneng. Ho utloisisa thepa ea viscosity ea tharollo ea metsi ea HPMC ho re thusa ho utloisisa hamolemo boitšoaro ba eona le ts'ebetso ea eona lits'ebetsong tse fapaneng.
1. Sebopeho sa lik'hemik'hale le thepa ea HPMC
HPMC e fumanoa ka phetoho ea lik'hemik'hale ea cellulose ea tlhaho, haholo-holo e entsoeng ke hydroxypropylation le methylation ea limolek'hule tsa cellulose. Ka sebopeho sa lik'hemik'hale tsa HPMC, ho kenyelletsoa ha lihlopha tsa methyl (-OCH₃) le hydroxypropyl (-OCH₂CHOHCH₃) ho etsa hore e qhibilihe ka metsing 'me e be le bokhoni bo botle ba ho fetola viscosity. Ts'ebetso ea viscosity ea tharollo ea eona ea metsi libakeng tse fapaneng le mocheso o angoa ke lintlha tse ngata tse kang boima ba limolek'hule, tekanyo ea ho fetola, khatello ea tharollo, joalo-joalo.
2. Kamano pakeng tsa viscosity le mahloriso
The viscosity ea AnxinCel®HPMC aqueous solution hangata e eketseha ka mahloriso a ntseng a eketseha. Lebaka ke hore libakeng tse phahameng, tšebelisano pakeng tsa limolek'hule ea ntlafatsoa, e leng se etsang hore ho be le khanyetso e eketsehileng ea phallo. Leha ho le joalo, litšoaneleho tsa solubility le viscosity tsa HPMC metsing le tsona li angoa ke boima ba limolek'hule. HPMC e nang le boima bo phahameng ba limolek'hule hangata e bonts'a viscosity e phahameng, athe boima bo tlase ba limolek'hule bo batla bo le tlase.
Maemong a tlase: Tharollo ea HPMC e bonts'a viscosity e tlase maemong a tlase (joalo ka tlase ho 0.5%). Nakong ena, tšebelisano pakeng tsa limolek'hule e fokola 'me metsi a metsi a molemo. Hangata e sebelisoa lits'ebetsong tse kang li-coatings le tokollo e tsitsitseng ea lithethefatsi.
Libakeng tse phahameng: Libakeng tse phahameng (joalo ka 2% kapa holimo), viscosity ea HPMC aqueous solution e eketseha haholo, e bonts'a thepa e ts'oanang le tharollo ea colloidal. Nakong ena, metsi a tharollo a tlas'a khanyetso e kholoanyane.
3. Kamano pakeng tsa viscosity le mocheso
The viscosity ea HPMC aqueous tharollo e haholo nahanela mocheso. Ha mocheso o ntse o eketseha, ho tsamaea pakeng tsa limolek'hule tsa metsi hoa eketseha, 'me ho sebelisana pakeng tsa limolek'hule tsa HPMC hoa fokola, ho fella ka ho fokotseha ha viscosity. Tšobotsi ena e etsa hore ts'ebeliso ea HPMC ka lithemparetjha tse fapaneng e bonts'e phetoho e matla. Ka mohlala, tlas'a maemo a phahameng a mocheso, viscosity ea HPMC hangata e fokotseha, e leng ea bohlokoa ka ho khetheha ts'ebetsong ea meriana, haholo-holo mefuteng ea litekanyetso tsa ho lokolloa ha lithethefatsi, moo liphetoho tsa mocheso li ka amang botsitso le phello ea tharollo.
4. Phello ea pH ho Viscosity
The viscosity ea HPMC aqueous solution e ka boela ea angoa ke boleng ba pH ba tharollo. Leha HPMC e le ntho e seng ea ionic, thepa ea eona ea hydrophilicity le viscosity e angoa haholo ke sebopeho sa limolek'hule le tikoloho ea tharollo. Leha ho le joalo, tlas'a maemo a acidic haholo kapa a alkaline, ho qhibiliha le sebopeho sa limolek'hule tsa HPMC li ka fetoha, kahoo tsa ama viscosity. Ka mohlala, tlas'a maemo a acidic, solubility ea HPMC e ka 'na ea fokola hanyenyane, e bakang viscosity e eketsehileng; ha e ntse e le tlas'a maemo a alkaline, hydrolysis ea HPMC e 'ngoe e ka etsa hore boima ba eona ba molek'hule bo fokotsehe, kahoo bo fokotsa viscosity ea eona.
5. Boima ba Limolek'hule le Viscosity
Boima ba limolek'hule ke e 'ngoe ea lintlha tsa bohlokoa tse amang viscosity ea tharollo ea metsi a HPMC. Boima bo phahameng ba limolek'hule bo eketsa ho ts'oaroa le ho hokahanya pakeng tsa limolek'hule, e leng se etsang hore ho be le viscosity e eketsehileng. Boima bo tlase ba molek'hule AnxinCel®HPMC e na le ho qhibiliha ho betere ka metsing le ka viscosity e tlase. Litlhokahalo tse fapaneng tsa kopo hangata li hloka khetho ea HPMC e nang le boima bo fapaneng ba limolek'hule. Ka mohlala, ka liphahlo le li-adhesives, boima bo phahameng ba molek'hule HPMC hangata bo khethoa bakeng sa ho khomarela hantle le ho phalla ha metsi; ha ho ntse ho etsoa litokisetso tsa meriana, boima bo tlaase ba molek'hule HPMC e ka sebelisoa ho laola sekhahla sa ho lokolloa ha lithethefatsi.
6. Kamano pakeng tsa sekhahla sa ho kuta le viscosity
The viscosity ea HPMC aqueous solution hangata e fetoha le sekhahla sa ho kuta, e bonts'a boits'oaro bo tloaelehileng ba pseudoplastic rheological. Mokelikeli oa pseudoplastic ke mokelikeli oo viscosity ea oona e fokotsehang butle-butle ka keketseho ea sekhahla sa ho kuta. Tšobotsi ena e nolofalletsa tharollo ea HPMC ho boloka viscosity e phahameng ka sekhahla se tlase sa ho kuta ha se sebelisoa, le ho ntlafatsa mokelikeli ka sekhahla se phahameng sa ho kuta. Ka mohlala, indastering ea ho roala, tharollo ea HPMC hangata e hloka ho bonts'a viscosity e phahameng ka tekanyo e tlaase ea ho kuta ha e sebelisoa ho etsa bonnete ba ho khomarela le ho lekana ha seaparo, ha nakong ea ts'ebetso ea kaho, ho hlokahala ho eketsa sekhahla sa ho kuta ho etsa hore ho be le metsi a mangata.
7. Litšobotsi tsa kopo le viscosity tsa HPMC
Litšobotsi tsa viscosity tsaHPMCetsa hore e sebelisoe haholo mafapheng a mangata. Ka mohlala, indastering ea meriana, HPMC e atisa ho sebelisoa e le moemeli oa ho lokolloa ha lithethefatsi, 'me molao oa eona oa viscosity o sebelisoa ho laola tekanyo ea ho lokolloa ha lithethefatsi; indastering ea kaho, HPMC e sebelisoa e le motenya ho ntlafatsa ts'ebetso le metsi a seretse le likhomaretsi; indastering ea lijo, HPMC e ka sebelisoa e le motenya, emulsifier le stabilizer ho ntlafatsa tatso le ponahalo ea lijo.
Litšobotsi tsa viscosity tsa tharollo ea metsi ea AnxinCel®HPMC ke senotlolo sa ts'ebeliso ea eona libakeng tse fapaneng. Ho utloisisa kamano ea eona le lintlha tse kang ho tsepamisa mohopolo, mocheso, pH, boima ba limolek'hule le sekhahla sa ho kuta ke tsa bohlokoa haholo bakeng sa ho ntlafatsa ts'ebetso ea sehlahisoa le ho ntlafatsa liphello tsa kopo.
Nako ea poso: Jan-27-2025