Cellulose, e leng e 'ngoe ea lik'hemik'hale tse ngata ka ho fetisisa lefatšeng, e sebelisoa haholo liindastering tse fapaneng ka lebaka la thepa ea eona e ikhethang. Indastering ea meriana, selulose le lintho tse tsoang ho eona li phetha karolo ea bohlokoa tsamaisong ea phano ea lithethefatsi, ho etsa lipilisi, ho roala maqeba le tse ling.
1. Binder ho Meetso ea Letlapa:
Lintho tse tsoang ho cellulose tse kang microcrystalline cellulose (MCC) le selulose e phofshoana li sebetsa e le lintho tse tlamahanyang ka katleho liforomong tsa letlapa. Ba ntlafatsa momahano le matla a mochini oa matlapa, ho netefatsa phepelo e ts'oanang ea lithethefatsi le litlaleho tse tsitsitseng tsa tokollo.
2. Disintegrant:
Lintho tse tsoang ho cellulose joalo ka croscarmellose sodium le sodium carboxymethyl cellulose (NaCMC) li sebetsa joalo ka li-disintegrants matlapeng, li thusa karohano e potlakileng ea matrix ea letlapa ha e kopana le maro a metsi. Thepa ena e ntlafatsa ho felisoa ha lithethefatsi le bioavailability.
3. Mekhoa e Laolehileng ea Phano ea Lithethefatsi:
Li-derivatives tsa cellulose ke likarolo tsa bohlokoa mefuteng e laoloang ea tokollo. Ka ho fetola sebopeho sa lik'hemik'hale kapa boholo ba likaroloana tsa selulose, li-profiles tsa ho lokolloa ha lithethefatsi tse tsitsitseng, tse atolositsoeng, kapa tse lebisitsoeng li ka finyelloa. Sena se lumella ho fana ka litlhare hantle, ho fokotsa makhetlo a mangata, le ho ntlafatsa ho latela melao ea bakuli.
4. Thepa ea ho roala:
Li-derivatives tsa cellulose tse kang ethyl cellulose le hydroxypropyl methylcellulose (HPMC) hangata li sebelisoa e le litlolo tsa filimi bakeng sa matlapa le granules. Li fana ka mokoallo oa tšireletso, li koahela litatso tse sa thabiseng, li laola ho lokolloa ha lithethefatsi, le ho matlafatsa botsitso.
5. Moemeli oa ho Tiisa le ho Tiisa:
Li-cellulose ethers tse kang HPMC le sodium carboxymethyl cellulose li sebelisoa e le lisebelisoa tse teteaneng le tse matlafatsang mefuteng ea litekanyetso tsa mokelikeli tse kang ho emisoa, li-emulsion le li-syrups. Li ntlafatsa viscosity, li thibela sedimentation, 'me li netefatsa kabo e tšoanang ea lithethefatsi.
6. E Kenyelelitsoe ho Liqapi tsa Lihlooho:
Meetsong ea lihlooho tse kang litlolo, litlolo, le li-gel, lihlahisoa tsa cellulose li sebetsa e le li-viscosity modifiers, li-emulsifiers le li-stabilizers. Li fana ka lintho tse lakatsehang tsa rheological, li ntlafatsa ho ata, 'me li khothalletsa ho khomarela letlalo kapa lera la mucous.
7. Liaparo tsa Maqeba:
Lisebelisoa tse thehiloeng ho cellulose, ho kenyeletsoa selulose e nang le oxidized le carboxymethyl cellulose, li sebelisoa ho roala maqeba ka lebaka la thepa ea tsona ea hemostatic, monyetla le antimicrobial. Liaparo tsena li khothalletsa ho fola ha maqeba, ho thibela tšoaetso, le ho boloka tikoloho ea maqeba e mongobo.
8. Scaffold in Tissue Engineering:
Li-scaffolds tsa cellulose li fana ka matrix e lumellanang le biodegradable bakeng sa lits'ebetso tsa boenjiniere ba lisele. Ka ho kenyelletsa li-agent kapa lisele tsa bioactive, li-scaffolds tse thehiloeng ho cellulose li ka ts'ehetsa nchafatso ea lisele le ho lokisoa maemong a fapaneng a bongaka.
9. Sebopeho sa Capsule:
Lintho tse tsoang ho cellulose tse kang hypromellose le hydroxypropyl cellulose li sebelisoa e le lisebelisoa tsa ho etsa li-capsule, tse fanang ka mokhoa o mong oa li-capsules tsa gelatin. Li-capsules tse thehiloeng ho cellulose li loketse ho etsoa hang-hang le tse fetotsoeng-ho lokolloa 'me li khethoa bakeng sa lithibelo tsa lijo tsa meroho kapa tsa bolumeli.
10. Carrier in Solid Dispersion Systems:
Li-cellulose nanoparticles li fumane tlhokomelo e le bajari ba lithethefatsi tse sa qhibilihang ka metsing ka har'a litsamaiso tse tiileng tsa ho hasana. Sebaka sa bona se phahameng, porosity, le biocompatibility li thusa ho ntlafatsoa ha lithethefatsi le bioavailability.
11. Likopo tse Khahlanong le Boqhekanyetsi:
Lisebelisoa tse thehiloeng ho cellulose li ka kenngoa ka har'a liphutheloana tsa meriana e le mehato e khahlanong le ho qhekella. Li-tag tse thehiloeng ho cellulose kapa lileibole tse nang le likarolo tsa ts'ireletso tse kentsoeng li ka thusa ho netefatsa lihlahisoa tsa meriana le ho thibela barekisi ba maiketsetso.
12. Phepelo ea Lithethefatsi ka ho hema:
Li-cellulose tse tsoang ho cellulose joalo ka cellulose ea microcrystalline le lactose li sebelisoa e le lijari bakeng sa metsoako ea phofshoana e omeletseng. Bajari bana ba etsa bonnete ba ho hasana ka mokhoa o ts'oanang oa lithethefatsi le ho thusa ho fana ka mokhoa o atlehang oa phefumoloho.
cellulose le lintho tse tsoang ho eona li sebetsa e le lisebelisoa tse fapaneng le lisebelisoa indastering ea meriana, li kenya letsoho ntlafatsong ea lihlahisoa tsa lithethefatsi tse bolokehileng, tse sebetsang hantle le tse bonolo ho mokuli. Thepa ea bona e ikhethang e etsa hore ho be le mefuta e mengata ea lisebelisoa, ho tloha ho li-tablet formulas ho ea ho tlhokomelo ea maqeba le boenjiniere ba lisele, ho etsa hore cellulose e be karolo ea bohlokoa mekhoeng ea kajeno ea meriana le lisebelisoa tsa bongaka.
Nako ea poso: Apr-18-2024