Hydroxypropyl methylcellulose (HPMC) ke motsoako oa polymer o se nang ionic o qhibilihang ka metsing o fumanoang ka ho fetola lik'hemik'hale tsa cellulose ea tlhaho. E sebelisoa haholo indastering ea lijo, meriana, litlolo le kaho, haholo-holo e le sekhomaretsi, setenya, emulsifier le moemeli oa ho emisa litokisetsong tsa meriana. Ts'ebetsong ea kopo, litšobotsi tsa viscosity tsa tharollo ea metsi ea HPMC li bohlokoa ts'ebetsong ea eona likarolong tse fapaneng.
1. Sebopeho le thepa ea hydroxypropyl methylcellulose
Sebopeho sa limolek'hule tsa HPMC se na le lihlopha tse peli tse nkang sebaka, hydroxypropyl (-CH₂CHOHCH₃) le methyl (-OCH₃), e etsang hore e be le matla a ho qhibiliha ha metsi le bokhoni ba ho fetola. Ketane ea limolek'hule ea HPMC e na le sebopeho se itseng se thata, empa se ka boela sa theha sebopeho sa marang-rang se nang le mahlakore a mararo ka tharollo e nang le metsi, e leng se etsang hore ho be le keketseho ea viscosity. Boima ba eona ba molek'hule, mofuta oa sebaka le tekanyo ea ho fetola (ke hore, tekanyo ea hydroxypropyl le methyl substitution ea yuniti ka 'ngoe) li na le tšusumetso ea bohlokoa ho viscosity ea tharollo.
2. Litšobotsi tsa viscosity tsa tharollo ea metsi
Litšobotsi tsa viscosity tsa tharollo ea metsi ea HPMC li amana haufi-ufi le lintlha tse kang mahloriso, boima ba limolek'hule, mocheso le pH boleng ba solvent. Ka kakaretso, viscosity ea tharollo ea metsi ea HPMC e eketseha ka keketseho ea khatello ea eona. Viscosity ea eona e bonts'a boits'oaro bo se nang Newtonian rheological, ke hore, ha sekhahla sa ho kuta se ntse se eketseha, viscosity ea tharollo e fokotseha butle-butle, e bonts'a ts'ebetso ea ho kuta.
(1) Phello ea ho tsepamisa mohopolo
Ho na le kamano e itseng pakeng tsa viscosity ea HPMC aqueous solution le mahloriso a eona. Ha mahloriso a HPMC a ntse a eketseha, litšebelisano tsa limolek'hule ka tharollo ea metsi li matlafatsoa, 'me ho kenngoa le ho hokahanya ha liketane tsa limolek'hule ho eketseha, ho fella ka ho eketseha ha viscosity ea tharollo. Maemong a tlase, viscosity ea tharollo ea metsi ea HPMC e eketseha ka mokhoa o ts'oanang le keketseho ea mahloriso, empa maemong a holimo, kholo ea viscosity ea tharollo e batla e bataletse mme e fihla boleng bo tsitsitseng.
(2) Phello ea boima ba molek’hule
Boima ba limolek'hule ba HPMC bo ama ka ho toba viscosity ea tharollo ea eona ea metsi. HPMC e nang le boima bo phahameng ba limolek'hule e na le liketane tse telele tsa limolek'hule 'me e ka theha mohaho o rarahaneng oa marang-rang a mararo ka tharollo e nang le metsi, e hlahisang viscosity e phahameng. Ka lehlakoreng le leng, HPMC e nang le boima bo tlase ba limolek'hule e na le sebopeho sa marang-rang se hlephileng le viscosity e tlase ka lebaka la liketane tsa eona tse khuts'oane tsa limolek'hule. Ka hona, ha u etsa kopo, ho bohlokoa haholo ho khetha HPMC e nang le boima bo loketseng ba limolek'hule ho fihlela phello e ntle ea viscosity.
(3) Phello ea mocheso
Mocheso ke ntlha ea bohlokoa e amang viscosity ea tharollo ea metsi a HPMC. Ha mocheso o ntse o eketseha, ho tsamaea ha limolek'hule tsa metsi hoa matlafala 'me ponahalo ea tharollo hangata e fokotseha. Lebaka ke hore ha mocheso o phahama, tokoloho ea ketane ea limolek'hule ea HPMC e eketseha 'me tšebelisano pakeng tsa limolek'hule e fokola, kahoo e fokotsa viscosity ea tharollo. Leha ho le joalo, karabelo ea HPMC ho tsoa ho lihlopha tse fapaneng kapa mefuta e fapaneng ho mocheso le eona e ka fapana, kahoo maemo a mocheso a hloka ho lokisoa ho latela litlhoko tse ikhethileng tsa kopo.
(4) Phello ea boleng ba pH
HPMC ka boeona ke motsoako o seng oa ionic, 'me viscosity ea tharollo ea eona ea metsi e lemoha liphetoho ho pH. Leha HPMC e bonts'a litšobotsi tse batlang li tsitsitse tsa viscosity tikolohong e nang le asiti kapa e sa nke lehlakore, ho solubility le viscosity ea HPMC e tla ameha maemong a asiti haholo kapa a alkaline. Ka mohlala, tlas'a acid e matla kapa maemo a matla a alkaline, limolek'hule tsa HPMC li ka 'na tsa senyeha ka mokhoa o itseng, kahoo li fokotsa viscosity ea tharollo ea eona ea metsi.
3. Tlhahlobo ea Rheological ea litšobotsi tsa viscosity tsa tharollo ea metsi a HPMC
Boitšoaro ba rheological ba tharollo ea metsi a HPMC hangata bo bonts'a litšobotsi tsa mokelikeli tseo e seng tsa Newtonian, ho bolelang hore viscosity ea eona ha e amane feela le lintlha tse kang khatello ea tharollo le boima ba limolek'hule, empa hape le sekhahla sa ho kuta. Ka kakaretso, ka litekanyetso tse tlaase tsa ho kuta, tharollo ea metsi ea HPMC e bontša viscosity e phahameng, ha sekhahla sa ho kuta se ntse se eketseha, viscosity e fokotseha. Boitšoaro bona bo bitsoa "ho kuta" kapa "ho kuta" 'me bo bohlokoa haholo lits'ebetsong tse ngata tse sebetsang. Ka mohlala, masimong a ho roala, ho lokisetsa meriana, ho sebetsana le lijo, joalo-joalo, litšoaneleho tsa ho kuta moriri oa HPMC li ka etsa bonnete ba hore viscosity e phahameng e bolokoa nakong ea likopo tse tlaase, 'me e ka phalla habonolo tlas'a maemo a ho kuta ka lebelo le phahameng.
4. Lintlha tse ling tse amang viscosity ea tharollo ea metsi a HPMC
(1) Phello ea letsoai
Ho eketsoa ha letsoai la solutes (joalo ka sodium chloride) ho ka eketsa viscosity ea tharollo ea metsi a HPMC. Lebaka ke hobane letsoai le ka ntlafatsa tšebelisano lipakeng tsa limolek'hule ka ho fetola matla a ionic a tharollo, e le hore limolek'hule tsa HPMC li thehe sebopeho sa marang-rang se kopaneng, kahoo se eketsa viscosity. Leha ho le joalo, phello ea mofuta oa letsoai le ho tsepamisa mohopolo ho viscosity le tsona li hloka ho fetoloa ho latela maemo a itseng.
(2) Phello ea li-additives tse ling
Ho kenyelletsa li-additives tse ling (tse kang li-surfactants, li-polymers, joalo-joalo) ho HPMC tharollo ea metsi e tla ama viscosity. Ka mohlala, li-surfactants li ka fokotsa viscosity ea HPMC, haholo-holo ha mahloriso a surfactant a le holimo. Ho phaella moo, li-polymers tse itseng kapa likaroloana li ka boela tsa sebelisana le HPMC le ho fetola thepa ea rheological ea tharollo ea eona.
Litšobotsi tsa viscosity tsahydroxypropyl methylcellulose tharollo ea metsi e angoa ke lintlha tse ngata, ho kenyelletsa mahloriso, boima ba limolek'hule, mocheso, pH ea bohlokoa, joalo-joalo Tharollo ea metsi ea HPMC hangata e bonahatsa thepa e sa tloaelehang ea rheological, e na le thepa e ntle ea ho teteka le ho kuta, 'me e sebelisoa haholo libakeng tse sa tšoaneng tsa indasteri le tsa meriana. Ho utloisisa le ho tseba litšobotsi tsena tsa viscosity ho tla thusa ho ntlafatsa ts'ebeliso ea HPMC lits'ebetsong tse fapaneng. Lits'ebetsong tse sebetsang, mofuta o nepahetseng oa HPMC le maemo a ts'ebetso a lokela ho khethoa ho latela litlhoko tse ikhethileng ho fumana viscosity e ntle le thepa ea rheological.
Nako ea poso: Mar-01-2025