Utloisisa ho qhibiliha ha HPMC ho li-solvents tse fapaneng

Ho utloisisa ho qhibiliha ha Hydroxypropyl Methylcellulose (HPMC) ho li-solvents tse fapaneng ho bohlokoa liindastering tse ngata, ho kenyeletsoa meriana, lijo, litlolo le kaho. HPMC ke semisynthetic, inert, viscoelastic polymer e nkiloeng ho selulose. Boitšoaro ba eona ba ho qhibiliha ka har'a lihlapolli tse fapaneng bo phetha karolo ea bohlokoa ts'ebelisong ea eona.

Selelekela ho HPMC:

Hydroxypropyl Methylcellulose (HPMC) ke motsoako oa selulose, o fetotsoeng ka ho phekola cellulose ka propylene oxide le methyl chloride. Tekanyo ea ho kenya sebaka sa hydroxypropyl le lihlopha tsa methoxy e laola thepa ea eona ea physicochemical, ho kenyelletsa le ho qhibiliha. HPMC e tumme ka thepa ea eona ea ho etsa lifilimi, e tenya, le ho e etsa emulsifying, e e etsa thepa e fapaneng liindastering tse fapaneng.

Lintlha tse Susumetsang ho Solubility:

Degree of Substitution (DS): DS ea HPMC, e emelang palo e tloaelehileng ea lihlopha tsa hydroxyl tse nketsoeng sebaka ka unit ea anhydroglucose, e susumetsa haholo ho qhibiliha ha eona. DS e phahameng e ntlafatsa ho qhibiliha ha metsi le ho fokotsa ho qhibiliha ha organic solvent.

Boima ba Molek'hule (MW): Li-polymers tse phahameng tsa HPMC li na le ho fokotsa ho qhibiliha ka lebaka la ho eketseha ha likamano tsa li-intermolecular.

Mocheso: Ka kakaretso, mocheso o phahameng o eketsa ho qhibiliha ha HPMC ho lihlapolli, haholo-holo lits'ebetsong tse thehiloeng metsing.

Litšebelisano tsa Solvent-Polymer: Thepa e qhibilihisang joalo ka polarity, hydrogen bonding bokhoni, le dielectric constant e ama HPMC solubility. Li-solvents tsa polar tse kang metsi, joala le li-ketone li atisa ho qhibiliha HPMC ka katleho ka lebaka la likamano tsa hydrogen bonding.

Ho tsepamisa maikutlo: Maemong a mang, ho eketsa khatello ea polymer ho ka lebisa mefokolong ea ho qhibiliha ka lebaka la ho eketseha ha viscosity le sebopeho se ka bang teng sa li-gel.

Solubility ka Litlhapi tse fapaneng:

Metsi: HPMC e bonts'a ho qhibiliha ho hoholo metsing ka lebaka la tlhaho ea eona ea hydrophilic le matla a ho kopanya haedrojene. The solubility e eketseha ka DS e phahameng le boima bo tlaase ba molek'hule.

Joala (Ethanol, Isopropanol): HPMC e bonts'a ho qhibiliha ho hoholo ha lino tse tahang ka lebaka la boteng ba lihlopha tsa hydroxyl tse tsamaisang likamano tsa hydrogen bonding.

Acetone: Acetone ke motsoako oa polar aprotic o khonang ho qhaqha HPMC hantle ka lebaka la polarity ea eona le bokhoni ba ho kopanya hydrogen.

Metsoako ea Chlorinated (Chloroform, Dichloromethane): Litlhapi tsena ha li ratehe haholo ka lebaka la mathata a tikoloho le polokeho. Leha ho le joalo, ba ka qhala HPMC ka katleho ka lebaka la polarity ea bona.

Metsoako e nkhang hamonate (Toluene, Xylene): HPMC e na le ho qhibiliha ho fokolang ho lihlapolli tse nkhang hamonate ka lebaka la tlhaho ea tsona e se nang polar, e lebisang likamanong tse fokolang.

Organic Acid (Acetic Acid): Organic acids e ka qhala HPMC ka ho sebelisana ha hydrogen bonding, empa tlhaho ea bona ea asiti e ka ama botsitso ba polymer.

Li-Ionic Liquids: Mekelikeli e meng ea ionic e batlisisitsoe bakeng sa bokhoni ba eona ba ho qhibiliha HPMC hantle, e fana ka mefuta e meng e ka bang teng ho e-na le lihlapolli tsa setso.

Lisebelisoa:

Meriana ea Meriana: HPMC e sebelisoa haholo mekhoeng ea meriana e le e tlamang, filimi ea pele, le e sa khaotseng ea ho lokolloa ka lebaka la ho lumellana ha eona, ho se chefo, le thepa ea tokollo e laoloang.

Indasteri ea Lijo: Ts'ebetsong ea lijo, HPMC e sebetsa e le setei, se tsitsitseng, le emulsifier lihlahisoa tse kang li-sauces, li-dressings le ice cream.

Kaho: HPMC e sebelisoa linthong tsa kaho tse kang samente, seretse, le lihlahisoa tse thehiloeng ho gypsum ho ntlafatsa ts'ebetso, ho boloka metsi le ho khomarela.

Litlolo: HPMC e fumanoa lihlahisoa tse fapaneng tsa litlolo tse kang litlolo, litlolo, le li-shampoo e le ntho e tiisang le filimi ea pele, e fanang ka sebopeho le botsitso.

Ho utloisisa ho solubility ha HPMC ho li-solvents tse fapaneng ho bohlokoa bakeng sa ho ntlafatsa ts'ebetso ea eona lits'ebetsong tse fapaneng. Lintlha tse kang tekanyo ea ho fetola, boima ba molek'hule, mocheso, le ho sebelisana ha solvent-polymer ho susumetsa boitšoaro ba eona ba ho qhibiliha. HPMC e bonts'a ho qhibiliha ho hoholo ha metsi le li-solvents tsa polar, ho e etsa hore e feto-fetohe haholo litabeng tsa meriana, lijo, kaho le litlolo. Lipatlisiso tse ling mabapi le litsamaiso tse ncha tsa solvent le mekhoa ea ts'ebetso li ka holisa lits'ebetso tse ka bang teng tsa HPMC liindasteri tse fapaneng ha li ntse li sebetsana le mathata a tikoloho le polokeho a amanang le lihlapolli tsa setso.