1.Selelekela:
Hydroxypropyl Methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo liindastering tse fapaneng, ho kenyeletsoa meriana, kaho le lijo. E 'ngoe ea likopo tsa eona tsa bohlokoa ke ho fetola thepa ea rheological ea ho emisoa. Rheology, thuto ea phallo le deformation ea thepa, e bohlokoa ho utloisisa le ho laola boitšoaro ba ho emisoa.
2.Viscosity Phetoho:
HPMC e tsejoa ka bokhoni ba eona ba ho fetola viscosity ea suspensions. Joaloka hydrophilic polymer, e monya metsi habonolo ebe e etsa sebopeho se kang gel. Ha e eketsoa ho emisoa, limolek'hule tsa HPMC li hydrate le ho ts'oara, li eketsa viscosity ea tsamaiso. Tekanyo ea phetoho ea viscosity e ipapisitse le lintlha tse kang khatello ea HPMC, boima ba limolek'hule, le boemo ba ho nkela sebaka. Ho tsepamisa maikutlo ho phahameng le boima ba limolek'hule tsa HPMC hangata ho fella ka ntlafatso e kholo ea viscosity.
3. Boitšoaro ba ho Beta-Seta:
Ntle le ho fetola viscosity, HPMC e ka susumetsa boits'oaro bo bobebe ba ho fanyeha. Shear-thinning e bolela ho fokotseha ha viscosity tlas'a khatello ea ho kuta e sebelisoang, e atisang ho bonoa lits'ebetsong tse ngata tsa ho emisa. Ho ba teng ha HPMC ho fetola index ea boitšoaro ba phallo ea ho emisoa, e lebisang ho thepa e ntlafalitsoeng ea ho kuta. Thepa ena e na le molemo ka ho khetheha lits'ebetsong moo ho lakatsoang ho tšela kapa ho fana habonolo, joalo ka lihlahisoa tsa meriana kapa lihlahisoa tsa lijo.
4.Suspension Stability:
Karolo e 'ngoe ea bohlokoa ea rheology ke botsitso ba ho emisa, e bolelang bokhoni ba likaroloana ho lula li qhalakantsoe le ho hanela sedimentation ka nako. HPMC e bapala karolo ea bohlokoa ho ntlafatseng botsitso ba ho emisa ka mekhoa e mengata. Taba ea pele, phello ea eona e teteaneng e thusa ho thibela ho putlama ha likaroloana ka ho eketsa viscosity ea mohato o tsoelang pele. Taba ea bobeli, HPMC e theha tšitiso e sirelletsang ho potoloha likaroloana, e fokotsa tšebelisano ea likaroloana le ho kopanya. Mokhoa ona oa steric stabilization o thusa ho boloka homogeneity ea ho emisoa.
5. Tšusumetso ea Thepa ea HPMC:
Tšusumetso ea rheological ea HPMC ho suspensions e susumetsoa ke thepa e 'maloa ea bohlokoa ea polymer. Boima ba limolek'hule bo ama boholo ba ketane ea ketane, ka lebaka leo, ntlafatso ea viscosity. Boima bo phahameng ba limolek'hule HPMC e atisa ho fana ka viscosity e kholo ho ho emisoa. Degree of substitution (DS), e bolelang palo ea hydroxypropyl le lihlopha tsa methoxy ho unit ea glucose, le eona e susumetsa boitšoaro ba rheological. Litekanyetso tse phahameng tsa DS li etsa hore ho be le hydration e matla le ho theha li-gel tse teteaneng, tse lebisang ho ho eketseha ha viscosity.
6. Lits'ebetso tse sebetsang:
Thepa ea rheological ea ho emisoa e fetotsoeng ka HPMC e fumana lits'ebetso tse atileng ho liindasteri tse fapaneng. Mekhatlong ea meriana, HPMC e sebelisoa e le moemeli ea emisang ho netefatsa kabo e tšoanang ea likaroloana tsa lithethefatsi le ho matlafatsa botsitso. Linthong tsa kaho tse kang lirekere tsa samente le li-grouts, HPMC e ntlafatsa ts'ebetso, ho khomarela le ho hanyetsa. Ka mokhoa o ts'oanang, lihlahisoa tsa lijo tse kang li-sauces, liaparo le lihlahisoa tsa lebese, HPMC e ntlafatsa sebopeho, botsitso le molomo.
Hydroxypropyl Methylcellulose (HPMC) ke polymer e sebetsang ka bongata e susumetsang haholo thepa ea rheological ea ho emisoa. Bokhoni ba eona ba ho fetola viscosity, ho ntlafatsa boits'oaro ba ho kuta, le ho ntlafatsa botsitso ba ho fanyeha ho etsa hore e be tlatsetso ea bohlokoa liindastering tse fapaneng. Ka ho utloisisa mekhoa eo HPMC e sebelisanang le ho emisoa ka eona, bafuputsi le baetsi ba lihlahisoa ba ka fetola tšebeliso ea eona ho finyella litšobotsi tse lakatsehang tsa rheological mefuteng e mengata ea likopo.
Nako ea poso: May-08-2024