1. Croscarmellose sodium(CMCNa e hokahantsoeng): copolymer e hokahantsoeng ea CMCNa
Thepa: Phofo e tšoeu kapa e bosoeu. Ka lebaka la sebopeho se amanang le sefapano, ha se qhibilihe ka metsing; e kokomoha ka potlako metsing ho makhetlo a 4-8 bophahamo ba eona ba pele. Phofo e na le mokelikeli o motle.
Kopo: Ke eona e sebelisoang ka ho fetesisa ea super disintegrant. Disintegrant bakeng sa matlapa a molomo, li-capsules, granules.
2. Carmellose calcium (CMCa e hokahantsoeng ka sefapano):
Thepa: phofo e tšoeu, e se nang monko, hygroscopic. 1% tharollo pH 4.5-6. E batla e sa qhibilihe ka har'a ethanol le ether solvent, ha e qhibilihe ka metsing, e sa qhibilihe ka har'a dilute hydrochloric acid, e qhibilihang hanyenyane ka alkali e hlapollang. kapa phofo e tsoeu. Ka lebaka la sebopeho se amanang le sefapano, ha se qhibilihe ka metsing; e kokomoha ha e monya metsi.
Kopo: disintegrant ea letlapa, binder, diluent.
3. Methylcellulose (MC):
Sebopeho: methyl ether ea selulose
Properties: Bosoeu ho ea bosehla bo bosoeu phofo kapa granules. Ha e qhibilihe ka metsing a chesang, tharollo ea letsoai e tletseng, joala, ether, acetone, toluene, chloroform; e qhibilihang ka har'a glacial acetic acid kapa motsoako o lekanang oa joala le chloroform. Ho qhibiliha ha metsi a batang ho amana le tekanyo ea ho fetola, 'me e qhibiliha haholo ha tekanyo ea ho e nkela sebaka e le 2.
Kopo: Letlapa le tlamang, matrix a letlapa le qhaqhoang kapa ho lokisoa ha nako e telele, tranelate kapa gel, e emisang le e teteaneng, ho roala letlapa, emulsion stabilizer.
4. Ethyl cellulose (EC):
Sebopeho: Ethyl ether ea selulose
Thepa: phofo e tšoeu kapa e mosehla-tšoeu le granules. Ha e qhibilihe ka metsing, marong a ka mpeng, glycerol le propylene glycol. E qhibiliha habonolo ka chloroform le toluene, 'me e etsa pula e tšoeu ha e le ethanol.
Kopo: Sesebelisoa se loketseng sa sejari se sa keneng sa metsi, se loketseng joalo ka matrix a sethethefatsi se sa utloeng metsi, sejari se sa keneng ka metsi, se tlamang letlapa, thepa ea lifilimi, thepa ea microcapsule le lisebelisoa tsa ho roala tse sa khaotseng, jj.
5. Hydroxyethyl Cellulose (HEC):
Sebopeho: Karolo ea hydroxyethyl ether ea selulose.
Properties: Phofo e bosehla bo bobebe kapa bo bosoeu ba lebese. E qhibiliha ka ho feletseng metsing a batang, metsi a chesang, acid e fokolang, setsi se fokolang, acid e matla, setsi se matla, se ke keng sa qhibiliha ka har'a metsoako e mengata ea lintho tse phelang (dimethyl sulfoxide, dimethylformamide), ka diol polar organic solvents E ka atoloha kapa ea qhibiliha ka mokhoa o fokolang.
Likopo: Lisebelisoa tsa polymer tse sa qhibilihang ka metsing; li-thickeners bakeng sa litokisetso tsa ophthalmic, otology le tšebeliso ea lihlooho; HEC ka lubricant bakeng sa mahlo a omileng, lilense tsa ho kopana le molomo o omileng; se sebedisoang ho ditlolo. E le setlamo, se etsang filimi, moemeli oa thickening, moemeli oa ho emisa le stabilizer bakeng sa lithethefatsi le lijo, e ka koahela likaroloana tsa lithethefatsi, e le hore likaroloana tsa lithethefatsi li ka bapala karolo ea ho lokolloa butle.
6. Hydroxypropyl Cellulose (HPC):
Sebopeho: Karolo e itseng ea polyhydroxypropyl ether ea selulose
Thepa: HPC e nkeloang sebaka e phahameng ke phofo e tšoeu kapa e mosehla hanyane. E qhibiliha ka methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide le dimethyl formamide, mofuta o phahameng oa viscosity ha o qhibilihe haholo. Ha e qhibilihe ka metsing a chesang, empa e ka ruruha. Thermal gelation: e qhibiliha habonolo metsing a ka tlase ho 38 ° C, gelatinized ka ho futhumala, 'me e etsa ho ruruha ha flocculent ho 40-45 ° C, e ka fumanoang ka ho pholile.
Likarolo tse hlahelletseng tsa L-HPC: ha li qhibilihe ka har'a metsi le li-solvents tsa manyolo, empa li ruruha ka metsing, 'me thepa ea ho ruruha e eketseha ka keketseho ea li-substituents.
Kopo: HPC e nkeloang sebaka e phahameng e sebelisoa e le binder ea letlapa, moemeli oa granulating, thepa ea ho roala filimi, hape e ka sebelisoa e le thepa ea filimi ea microencapsulated, thepa ea matrix le lisebelisoa tse thusang tsa letlapa la ho boloka gastric, thickener le Protective colloids, hape e sebelisoang hangata ho li-patches tsa transdermal.
L-HPC: Haholo-holo e sebelisoa e le letlapa la disintegrant kapa binder bakeng sa granulation e metsi, e le matrix ea letlapa le tsoelang pele, joalo-joalo.
7. Hypromellose (HPMC):
Sebopeho: Karolo ea methyl le karolo ea polyhydroxypropyl ether ea selulose
Thepa: phofo e tšoeu kapa e tšoeu kapa granular. E qhibiliha ka metsing a batang, ha e qhibilihe ka metsing a chesang, 'me e na le thepa ea mocheso oa mocheso. E qhibiliha ka methanol le litharollo tsa ethanol, hydrocarbons ea chlorinated, acetone, joalo-joalo.
Kopo: Sehlahisoa sena ke tharollo ea metsi e tlaase-viscosity e sebelisoang e le thepa ea ho roala filimi; tharollo e phahameng ea viscosity organic solvent e sebelisoa e le letlapa le tlamang, 'me sehlahisoa se phahameng sa viscosity se ka sebelisoa ho thibela matrix a ho lokolloa ha lithethefatsi tse qhibilihisang metsi; joalo ka ha mahlo a theoha a teteaneng bakeng sa lacquer le meokho ea maiketsetso, le moemeli oa ho kolobisa bakeng sa lilense tsa ho kopana.
8. Hypromellose Phthalate (HPMCP):
Sebopeho: HPMCP ke phthalic acid halofo ea ester ea HPMC.
Thepa: Li-flakes kapa li-granules tse 'mala o mosoeu kapa o mosoeu. Ha e qhibilihe ka har'a metsi le tharollo ea asiti, ha e qhibilihe ka har'a hexane, empa e qhibiliha habonolo ka acetone:methanol, acetone:ethanol kapa methanol: chloromethane motsoako.
Kopo: Mofuta o mocha oa thepa ea ho roala e nang le ts'ebetso e babatsehang, e ka sebelisoang e le ho roala filimi ho pata monko o sa tloaelehang oa matlapa kapa granules.
9. Hypromellose Acetate Succinate (HPMCAS):
Sebopeho: Li-ester tse tsoakiloeng tsa acetic le succinic tsaHPMC
Properties: Bosoeu ho ea bosehla bo bosoeu phofo kapa granules. E qhibiliha ka sodium hydroxide le sodium carbonate solution, e qhibilihang habonolo ka har'a acetone, methanol kapa ethanol: metsi, dichloromethane: motsoako oa ethanol, ha e qhibilihe ka metsing, ethanol le ether.
Kopo: E le lisebelisoa tsa ho roala letlapa, lisebelisoa tsa ho roala ka mokhoa o tsitsitseng le lisebelisoa tsa ho roala filimi.
10. Agare:
Sebopeho: Agar ke motsoako oa bonyane li-polysaccharides tse peli, hoo e ka bang 60-80% ea agarose e sa nke lehlakore le 20-40% ea agarose. Agarose e entsoe ka likarolo tse pheta-phetoang tsa agarobiose moo D-galactopyranosose le L-galactopyranosose li hokahaneng ho 1-3 le 1-4.
Thepa: Agar e translucent, light yellow square cylinder, slender strip kapa scaly flake kapa phofo. Ha e qhibilihe ka metsing a batang, e qhibilihang ka metsing a belang. E ruruha ka makhetlo a 20 ka metsing a batang.
Kopo: E le moemeli ea tlamang, setsi sa mafura, setsi sa suppository, emulsifier, stabilizer, suspending agent, hape e le poultice, capsule, sirapo, jelly le emulsion.
Nako ea poso: Apr-26-2024