Hydroxypropyl Methylcellulose (HPMC)ke motsoako oa selulose oa maiketsetso le motsoako oa semi-synthetic polymer. E sebelisoa haholo liindastering tse ngata tse kang kaho, meriana, lijo, litlolo le litlolo. Joalo ka ether ea cellulose e seng ea ionic, HPMC e na le ho qhibiliha ha metsi hantle, thepa ea ho etsa lifilimi, ho khomarela le emulsification, ka hona e na le bohlokoa ba kopo ea bohlokoa masimong a mangata.
1. Sebopeho sa lik'hemik'hale le thepa ea HPMC
Sebopeho sa limolek'hule tsa HPMC se tsoa ho cellulose ea tlhaho. Ka mor'a phetoho ea lik'hemik'hale, lihlopha tsa methyl (-OCH₃) le hydroxypropyl (-OCH₂CH₂OH) li kenngoa ka har'a ketane ea cellulose. Sebopeho sa eona sa mantlha sa lik'hemik'hale ke se latelang:
Limolek'hule tsa cellulose li entsoe ka li-unit tsa tsoekere tse hokahantsoeng ke β-1,4-glycosidic bond;
Lihlopha tsa Methyl le hydroxypropyl li kenngoa ka har'a ketane ea cellulose ka karabelo ea sebaka.
Sebopeho sena sa lik'hemik'hale se fa HPMC thepa e latelang:
Ho qhibiliha ha metsi: Ka ho laola tekanyo ea ho fetola lihlopha tsa methyl le hydroxypropyl, HPMC e ka fetola ho qhibiliha ha eona ha metsi. Ka kakaretso, HPMC e ka etsa tharollo ea viscous metsing a batang mme e na le ho qhibiliha ha metsi hantle.
Tokiso ea Viscosity: Viscosity ea HPMC e ka laoloa ka nepo ka ho lokisa boima ba limolek'hule le tekanyo ea ho kenya sebaka ho fihlela litlhoko tse fapaneng tsa kopo.
Ho hanyetsa mocheso: Kaha HPMC ke thepa ea polymer ea thermoplastic, mocheso oa eona oa mocheso o batla o le motle 'me o ka boloka ts'ebetso e tsitsitseng ka har'a mocheso o itseng.
Biocompatibility: HPMC ke ntho e se nang chefo le e sa hloekiseng, kahoo e ratoa haholo-holo lefapheng la bongaka.
2. Mokhoa oa ho itokisa oa HPMC
Mokhoa oa ho lokisa oa HPMC o phethoa haholo-holo ke karabelo ea esterification ea selulose. Mehato e khethehileng ke e latelang:
Ho qhibiliha ha cellulose: Ntlha ea pele, kopanya selulose ea tlhaho le solvent (joaloka chloroform, alcohol solvent, joalo-joalo) ho e qhaqha hore e be motsoako oa selulose.
Phetoho ea lik'hemik'hale: Methyl le hydroxypropyl chemical reagents (joaloka metsoako ea chloromethyl le allyl alcohol) li kenngoa tharollong ho baka phetoho.
Neutralization le ho omisa: Boleng ba pH bo fetoloa ka ho eketsa asiti kapa alkali, 'me karohano, tlhoekiso le ho omisa li etsoa kamora karabelo ho fihlela qetellong ho fumana hydroxypropyl methylcellulose.
3. Lisebelisoa tsa mantlha tsa HPMC
Thepa e ikhethang ea HPMC e etsa hore e sebelisoe haholo mafapheng a mangata. Tse latelang ke tse ling tsa libaka tsa mantlha tsa kopo:
(1) Tšimo ea kaho: HPMC e sebelisoa haholo indastering ea kaho, haholo-holo linthong tsa kaho tse kang samente, seretse le lirafshoa. E ka ntlafatsa mokelikeli, ho khomarela le ho boloka metsi a motsoako. Haholo-holo ka seretse se omeletseng, HPMC e ka ntlafatsa ts'ebetso ea kaho, ea eketsa ho khomarela seretse, le ho qoba mapetsong a slurry ea samente nakong ea ho thatafala.
(2) Tšimo ea meriana: Lefapheng la meriana, HPMC e atisa ho sebelisoa ho lokisa matlapa, li-capsules le lithethefatsi tsa metsi. Joaloka moemeli oa ho etsa lifilimi, motenya le stabilizer, e ka ntlafatsa ho qhibiliha le bioavailability ea lithethefatsi. Matlapeng, HPMC ha e khone ho laola sekhahla sa ho lokolloa ha lithethefatsi feela, empa hape e ntlafatsa botsitso ba lithethefatsi.
(3) Tšimo ea lijo: HPMC e ka sebelisoa ts'ebetsong ea lijo e le motenya, emulsifier le stabilizer. Ka mohlala, lijong tse se nang mafura le tse se nang mafura, HPMC e ka fana ka tatso e ntle le mokhoa o motle le ho eketsa botsitso ba sehlahisoa. E boetse e sebelisoa haholo lijong tse leqhoa ho thibela ho arohana ha metsi kapa ho thehoa ha kristale ea leqhoa.
(4) Litlolo: Ka litlolo, HPMC e atisa ho sebelisoa e le motenya, emulsifier le moisturizer. E ka ntlafatsa sebopeho sa litlolo, ho etsa hore ho be bonolo ho li sebelisa le ho monya. Haholo-holo ka litlolo tsa letlalo, li-shampoo, limaske tsa sefahleho le lihlahisoa tse ling, tšebeliso ea HPMC e ka ntlafatsa maikutlo le botsitso ba sehlahisoa.
(5) Liaparo le lipente: Ka indasteri ea liphahlo le lipente, HPMC, e le motenya le emulsifier, e ka fetola rheology ea ho roala, ho etsa hore seaparo se be se ts'oanang le se boreleli. E ka boela ea ntlafatsa ho hanyetsa metsi le thepa e khahlanong le ho senya ea ho roala, le ho eketsa ho thatafala le ho khomarela ho roala.
4. Litebello tsa 'maraka le mekhoa ea ntlafatso ea HPMC
Ha batho ba ntse ba ela hloko haholoanyane ts'ireletso ea tikoloho le bophelo bo botle, HPMC, e le thepa ea polymer e tala le e seng chefo, e na le litebello tse pharaletseng. Haholo-holo indastering ea meriana, ea lijo le ea litlolo, ts'ebeliso ea HPMC e tla atolosoa le ho feta. Nakong e tlang, ts'ebetso ea tlhahiso ea HPMC e kanna ea ntlafatsoa le ho feta, mme keketseho ea tlhahiso le phokotso ea litšenyehelo e tla khothaletsa ts'ebeliso ea eona liindastering tse ling.
Ka nts'etsopele ea lisebelisoa tse bohlale le theknoloji ea tokollo e laoloang, ts'ebeliso ea HPMC lits'ebetsong tse bohlale tsa phano ea lithethefatsi le eona e tla fetoha sebaka sa lipatlisiso. Mohlala, HPMC e ka sebelisoa ho lokisa bajari ba lithethefatsi ka ts'ebetso e laoloang ea tokollo ho lelefatsa nako ea phello ea lithethefatsi le ho ntlafatsa ts'ebetso.
Hydroxypropyl methylcelluloseke thepa ea polymer e nang le ts'ebetso e ntle haholo le ts'ebeliso e pharaletseng. Ka ts'ebetso ea eona e babatsehang ea ho qhibiliha ha metsi, bokhoni ba ho fetola viscosity le biocompatibility e ntle, HPMC e na le likopo tsa bohlokoa likarolong tse ngata tse kang kaho, meriana, lijo, litlolo, joalo-joalo Ka tsoelo-pele ea saense le thekenoloji, ts'ebetso ea tlhahiso le masimo a kopo ea HPMC a ka 'na a tsoela pele ho atolosa, le menyetla ea tsoelo-pele ea nakong e tlang e pharaletseng haholo.
Nako ea poso: Mar-11-2025