Hydroxypropyl methylcellulose-HPMC

Hydroxypropyl methylcellulose (HPMC)ke motsoako o sebetsang ka mefuta e mengata o nang le lits'ebetso tse fapaneng ho pholletsa le liindasteri tse fapaneng, ho kenyeletsoa meriana, lijo, litlolo, kaho, le tse ling.

Sebopeho le Sebopeho sa Lik'hemik'hale:
HPMC ke semi-synthetic, inert, viscoelastic polymer e nkiloeng ho selulose ka phetoho ea lik'hemik'hale. E entsoe ka likarolo tse pheta-phetoang tsa limolek'hule tsa tsoekere, tse ts'oanang le selulose, ka lihlopha tse eketsehileng tsa hydroxypropyl le methyl tse khomaretsoeng mokokotlong oa cellulose. The degree of substitution (DS) ea lihlopha tsena e etsa qeto ea thepa ea HPMC, ho kenyelletsa le solubility, viscosity, le boitšoaro ba gelation.

Mokhoa oa Tlhahiso:
Tšimoloho ea HPMC e kenyelletsa mehato e mengata. Qalong, cellulose e phekoloa ka alkali ho kenya tšebetsong lihlopha tsa hydroxyl. Kamora moo, propylene oxide e arajoa ka cellulose e kentsoeng ho hlahisa lihlopha tsa hydroxypropyl. Qetellong, methyl chloride e sebelisoa ho hokela lihlopha tsa methyl ho selulose ea hydroxypropylated, e hlahisang sebopeho sa HPMC. DS ea hydroxypropyl le lihlopha tsa methyl li ka laoloa nakong ea ts'ebetso ea tlhahiso ho hlophisa thepa ea HPMC bakeng sa lits'ebetso tse ikhethileng.

Thepa ea Sebele:
HPMC ke phofo e tšoeu ho isa ho e tšoeu e nang le metsi a mangata haholo. E qhibiliha metsing a batang le a chesang, 'me e etsa litharollo tse hlakileng, tse hlakileng. The viscosity ea HPMC ditharollo itšetlehile ka lintlha tse kang boima ba molek'hule, tekanyo ea ho nka sebaka, 'me mahloriso. Ntle le moo, HPMC e bonts'a boits'oaro ba pseudoplastic, ho bolelang hore viscosity ea eona e ea fokotseha tlasa khatello ea ho kuta, e etsa hore e tšoanelehe bakeng sa lits'ebetso tse joalo ka li-ajenti tse teteaneng, li-stabilizer le baetsi ba lifilimi.

Lisebelisoa:
Meriana:HPMCe sebelisoa haholo mekhoeng ea meriana e le setlamo sa pele, sa pele sa filimi, se sa thekeseleng, le se lokolotsoeng ka matla matlapeng, li-capsules le li-topical formulations. Sebopeho sa eona se sa sebetseng, ho lumellana le metsoako e sebetsang ea meriana (APIs), le bokhoni ba ho fetola kinetics ea tokollo ea lithethefatsi e etsa hore e be mothusi oa bohlokoa lits'ebetsong tsa phepelo ea lithethefatsi.

Indasteri ea Lijo: Indastering ea lijo, HPMC e sebelisoa e le setei, emulsifier, stabilizer le gelling agent lihlahisoa tse fapaneng tse kang li-sauces, dressings, desserts, le lintho tsa ho baka. E ntlafatsa sebopeho, e matlafatsa molomo, 'me e fana ka botsitso ho metsoako ea lijo ntle le ho fetola tatso kapa monko.

Litlolo: HPMC e kenyelelitsoe mekhoeng ea litlolo e le filimi ea pele, e teteaneng, le e emisang ka har'a litlolo, litlolo, li-shampoo le lihlahisoa tse ling tsa tlhokomelo ea motho. E fana ka viscosity, e ntlafatsa ho ata, 'me e ntlafatsa botsitso ba sehlahisoa ha e ntse e fana ka melemo ea mongobo le boemo ba letlalo le moriri.

Indasteri ea Kaho: Indastering ea kaho, HPMC e sebelisoa e le setei, se bolokang metsi, le se matlafatsang ts'ebetso ea seretse se thehiloeng ho samente, sekhomaretsi sa lithaele, samente le li-grouts. E ntlafatsa ts'ebetso, e fokotsa karohano ea metsi, 'me e ntlafatsa ho khomarela, ho fella ka thepa ea mohaho e tšoarellang le e phahameng.

Lisebelisoa tse Ling: HPMC e fumana lits'ebetso likarolong tse fapaneng tse kang khatiso ea masela, lirafshoa, lipente, le lihlahisoa tsa temo. E sebetsa e le ntho e matlafatsang, rheology modifier, le binder lits'ebetsong tsena, e kenya letsoho ts'ebetsong le boleng ba sehlahisoa.

Hydroxypropyl methylcellulose (HPMC)ke polymer e sebetsang ka bongata e nang le lits'ebetso tse atileng liindastering tse fapaneng ka lebaka la motsoako oa eona o ikhethang oa thepa, ho kenyeletsoa ho qhibiliha ha metsi, taolo ea viscosity, bokhoni ba ho etsa lifilimi, le biocompatibility. Ho feto-fetoha ha eona le ho lumellana ha eona le lintho tse fapaneng ho e etsa motsoako oa bohlokoa ho tsa meriana, lihlahisoa tsa lijo, litlolo, le thepa ea kaho, har'a tse ling. Ha lipatlisiso le tsoelo-pele ea mahlale e ntse e tsoela pele, ts'ebeliso ea HPMC e lebelletsoe ho hola ho ea pele, ho tsamaisa boqapi le ho ntlafatsa ts'ebetso ea lihlahisoa makaleng a fapaneng.