Hydroxypropyl methylcelluloseke mofuta oa selulose e seng ionic e tsoakiloeng ether. Ho fapana le ionic methyl carboxymethyl cellulose motsoako oa ether, ha e sebetsane le litšepe tse boima. Ka lebaka la likarolo tse fapaneng tsa methoxyl content le hydroxypropyl content ho hydroxypropyl methylcellulose le viscosities e fapaneng, ho na le mefuta e mengata e nang le thepa e fapaneng, mohlala, methoxyl e phahameng le litaba tse tlaase tsa hydroxypropyl Ts'ebetso ea eona e haufi le ea methyl cellulose, ha ts'ebetso ea methoxyl e tlaase le e phahameng ea methylprose ea hydroxyl hydroxypropyl cellulopy. Leha ho le joalo, mofuteng o mong le o mong, le hoja ho na le palo e nyenyane feela ea sehlopha sa hydroxypropyl kapa sehlopha se senyenyane sa methoxyl, ho na le phapang e kholo ea ho qhibiliha ha metsoako ea lintho tse phelang kapa mocheso oa flocculation ka tharollo ea metsi.
(1) Lintho tsa ho qhibiliha ha hydroxypropyl methylcellulose
① Ho qhibiliha ha hydroxypropyl methylcellulose ka metsingHydroxypropyl methylcelluloseha e le hantle ke mofuta oa methylcellulose e fetotsoeng ke propylene oxide (methoxy-propylene), kahoo e ntse e e-na le thepa e tšoanang le ea methyl cellulose e nang le litšobotsi tse tšoanang tsa ho qhibiliha ha metsi a batang le ho se be le metsi a chesang. Leha ho le joalo, ka lebaka la sehlopha se fetotsoeng sa hydroxypropyl, mocheso oa eona oa gelation metsing a chesang o phahame haholo ho feta oa methyl cellulose. Mohlala, viscosity ea hydroxypropyl methylcellulose aqueous solution e nang le 2% methoxy content substitution degree DS=0.73 le hydroxypropyl content MS=0.46 ke 500 mpa·s ho 20 ° C, le mocheso oa eona oa gel E ka fihla haufi le 100 ° C, ha methyl5 ° C selulose e ka ba feela ho 5 ° C. Ha e le ho qhibiliha ha eona metsing, le eona e ntlafalitsoe haholo. Mohlala, hydroxypropyl methylcellulose e entsoeng ka granular (sebopeho sa granular 0.2 ~ 0.5mm ho 20 ° C se nang le viscosity ea 4% ea aqueous ea 2pa•s e ka rekoa ka mocheso oa kamore, e qhibiliha habonolo metsing ntle le ho pholile.
② Ho qhibiliha ha hydroxypropyl methylcellulose ho li-solvents tsa organic ho qhibiliha ha hydroxypropyl methylcellulose ho li-solvents tsa organic le hona ho molemo ho feta tsa methylcellulose. Methylcellulose e hloka ho ba le tekanyo ea phetoho ea methoxyl ea 2.1 Lihlahisoa tse ka holimo, empa tse nang le hydroxypropyl MS = 1.5 ~ 1.8 le methoxy DS=0.2 ~ 1.0, high-viscosity hydroxypropyl methylcellulose e nang le tekanyo e feletseng ea phallo e ka holimo ho 1.8 e qhibilihisoa ka tharollo ea methanos le ethanos thermos-polasetiki le ho qhibiliha ha metsi. E boetse e qhibiliha ka har'a hydrocarbons ea chlorine joalo ka methylene chloride le chloroform, le lihlapolli tsa tlhaho tse kang acetone, isopropanol le diacetone joala. Ho qhibiliha ha eona ka har'a metsoako ea tlhaho ho molemo ho feta ho qhibiliha ha metsi.
(2) Lintlha tse Susumetsang Viscosity ea Hydroxypropyl Methyl Cellulose Tlhaloso e tloaelehileng ea viscosity ea hydroxypropyl methyl cellulose e tšoana le ea li-cellulose ethers tse ling. E lekanyetsoa ho 20 ° C ka 2% ea tharollo e nang le metsi e le maemo. Viscosity ea sehlahisoa se tšoanang e eketseha ka keketseho ea mahloriso. Bakeng sa lihlahisoa tse nang le litekanyo tse fapaneng tsa limolek'hule sebakeng se le seng, sehlahisoa se nang le boima bo boholo ba limolek'hule se na le viscosity e phahameng. Kamano ea eona le mocheso e tšoana le ea methyl cellulose. Ha mocheso o phahama, viscosity e qala ho theoha, empa ha e fihla mocheso o itseng, viscosity e phahama ka tšohanyetso 'me gelation e etsahala. Mocheso oa gel oa lihlahisoa tse tlaase-viscosity o phahame. e phahame. Ntlha ea eona ea gel ha e amane feela le viscosity ea ether, empa hape e amana le karolelano ea motsoako oa sehlopha sa methoxyl le sehlopha sa hydroxypropyl ka ether le boholo ba tekanyo ea kakaretso ea ho fetola. Ho lokela ho hlokomeloa hore hydroxypropyl methylcellulose le eona ke pseudoplastic, 'me tharollo ea eona e tsitsitse mocheso oa kamore ntle le ho senyeha ha viscosity ntle le monyetla oa ho senyeha ha enzymatic.
(3) Mamello ea letsoai ea hydroxypropyl methylcellulose Kaha hydroxypropyl methylcellulose ke ether e seng ea ionic, ha e ionized ka har'a mecha ea litaba ea metsi, ho fapana le li-ethers tse ling tsa ionic cellulose, tse kang carboxymethyl Base cellulose, ka tharollo ea ho itšoara ka li-ion tse boima tsa tšepe le precipitate. Matsoai a akaretsang a kang chloride, bromide, phosphate, nitrate, joalo-joalo a ke ke a putlama ha a eketsoa tharollong ea eona ea metsi. Leha ho le joalo, ho phaella ha letsoai ho na le tšusumetso e itseng ho mocheso oa flocculation oa tharollo ea eona ea metsi. Ha letsoai le ntse le eketseha, mocheso oa gel o fokotseha. Ha letsoai le le ka tlas'a ntlha ea flocculation, viscosity ea tharollo e atisa ho eketseha. Ka hona, tekanyo e itseng ea letsoai e eketsoa, ha e sebelisoa, e ka finyella phello e teteaneng haholoanyane moruong. Ka hona, lits'ebetsong tse ling, ho molemo ho sebelisa motsoako oa cellulose ether le letsoai ho feta motsoako o phahameng oa tharollo ea ether ho finyella phello e teteaneng.
(4) Hydroxypropyl methylcellulose acid le alkali resistance Hydroxypropyl methylcellulose ka kakaretso e tsitsitse ho li-acids le alkalis, 'me ha e amehe ka har'a pH 2 ~ 12. E ka mamella palo e itseng ea acid e khanyang, Tse kang formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, joalo-joalo Empa acid e concentrated e na le phello ea ho fokotsa viscosity. Li-alkali tse kang caustic soda, potash ea caustic le metsi a lime ha li na phello ho eona, empa li ka eketsa viscosity ea tharollo hanyenyane, ebe li fokotsa butle-butle.
(5) Miscibility ea hydroxypropyl methylcellulose Hydroxypropyl methylcellulose tharollo e ka kopanngoa le metsoako ea polymer e qhibilihang ka metsi hore e be tharollo e ts'oanang le e hlakileng e nang le viscosity e phahameng. Metsoako ena ea polymer e kenyelletsa polyethylene glycol, polyvinyl acetate, polysilicone, polymethylvinyl siloxane, hydroxyethyl cellulose, le methyl cellulose. Metsoako ea tlhaho e phahameng ea limolek'hule joalo ka gum arabic, tsie bean gum, karaya gum, joalo-joalo le eona e na le tumellano e ntle le tharollo ea eona. Hydroxypropyl methylcellulose e ka boela ea tsoakoa le mannitol ester kapa sorbitol ester ea stearic acid kapa palmitic acid, hape e ka tsoakoa le glycerin, sorbitol le mannitol, 'me metsoako ena e ka sebelisoa e le hydroxypropyl methylcellulose Plasticizer bakeng sa selulose.
(6) Mokelikeli o qhibilihang ka metsingli-cellulose ethersea hydroxypropyl methylcellulose e ka tsamaisa holim'a marang-rang le aldehydes, e le hore li-ether tsena tse qhibilihang ka metsi li tšeloe ka har'a tharollo 'me li se ke tsa qhibiliha metsing. Li-aldehyde tse etsang hore hydroxypropyl methylcellulose e se ke ea qhibiliha li kenyelletsa formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, joalo-joalo Ha u sebelisa formaldehyde, tlhokomelo e khethehileng e lokela ho lefshoa ho boleng ba pH ba tharollo, eo glyoxal e itšoarang ka eona ka potlako, kahoo glyoxal e atisa ho sebelisoa ha ho etsoa lihlahisoa tsa indasteri. Tekanyo ea mofuta ona oa motsoako o kopanyang tharollo ke 0.2% ~ 10% ea boima ba ether, haholo-holo 7% ~ 10%, mohlala, 3.3% ~ 6% ea glyoxal ke eona e loketseng ka ho fetisisa. Ka kakaretso, mocheso oa phekolo ke 0 ~ 30 ℃, 'me nako ke 1 ~ 120min. Karabelo ea crosslinking e lokela ho etsoa tlas'a maemo a acidic. Ka kakaretso, pH ea tharollo e fetoloa hoo e ka bang 2 ~ 6 ka ho eketsa asiti e matla ea inorganic kapa organic carboxylic acid tharollong, haholo-holo pakeng tsa 4 ~ 6, ebe li-aldehydes li eketsoa ho phethahatsa karabelo e kopanyang. Asiti e sebelisitsoeng e na le hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy-acetic acid, succinic acid kapa citric acid joalo-joalo, moo ka formic acid kapa acetic acid e leng bohlale, le formic acid e nepahetse. Asiti le aldehyde le tsona li ka eketsoa ka nako e le 'ngoe ho lumella tharollo hore e be le karabelo e hokahanyang ka har'a mofuta o lakatsehang oa pH. Hangata karabelo ena e sebelisoa ts'ebetsong ea ho qetela ea phekolo nakong ea ho lokisoa ha cellulose ethers. Kamora hore cellulose ether e se ke ea qhibiliha, ho bonolo ho e sebelisa.
20 ~ 25 ℃ metsi bakeng sa ho hlatsoa le ho hloekisa. Ha sehlahisoa se sebelisoa, lintho tsa alkaline li ka kenngoa tharollong ea sehlahisoa ho fetola pH ea tharollo hore e be alkaline, 'me sehlahisoa se tla qhibiliha ka tharollo kapele. Mokhoa ona o boetse o sebetsa ho phekola filimi ka mor'a hore tharollo ea cellulose ether e etsoe filimi ho e etsa filimi e sa tsitsang.
(7) Ho hanyetsa ha enzyme ea hydroxypropyl methylcellulose ke theoretically cellulose derivatives, joalo ka sehlopha se seng le se seng sa anhydroglucose, haeba ho na le sehlopha se tlamahaneng se nkang sebaka, ha ho bonolo ho tšoaetsoa ke likokoana-hloko, empa ha e le hantle sehlahisoa se feliloeng Ha boleng ba phapanyetso bo feta 1, e tla boela e fokotsehe, e leng se bolelang hore karolo e 'ngoe le e 'ngoe ea cellulose e fetoha. ketane ha e ts'oane ka ho lekana, 'me likokoana-hloko li ka senyeha sehlopheng se sa nkeng sebaka sa anhydroglucose ho theha tsoekere, e le limatlafatsi bakeng sa likokoana-hloko ho monya. Ka hona, haeba tekanyo ea etherification substitution ea selulose e eketseha, ho hanyetsa khoholeho ea enzymatic ea cellulose ether le eona e tla eketseha. Ho ea ka litlaleho, tlas'a maemo a laoloang, liphello tsa hydrolysis tsa li-enzyme tse entsoeng, viscosity e setseng ea hydroxypropyl methylcellulose (DS = 1.9) ke 13.2%, methylcellulose (DS = 1.83) ke 7.3%, methylcellulose (DS = 1.66) ke 3.8 hydroxyethyl . Ho ka bonoa hore hydroxypropyl methylcellulose e na le matla a matla a anti-enzyme. Ka hona, khanyetso e ntle ea enzyme ea hydroxypropyl methylcellulose, e kopantsoeng le thepa ea eona e ntle ea dispersibility, thickening le filimi-forming, e sebelisoa ka liphahlo tsa metsi-emulsion, joalo-joalo, 'me ka kakaretso ha ho hlokahale ho eketsa li-preservatives. Leha ho le joalo, bakeng sa polokelo ea nako e telele ea tharollo kapa tšilafalo e ka 'nang ea e-ba teng ka ntle, li-preservatives li ka eketsoa e le tšireletso,' me khetho e ka khethoa ho ea ka litlhoko tsa ho qetela tsa tharollo. Phenylmercuric acetate le manganese fluorosilicate ke li-preservatives tse sebetsang hantle, empa kaofela li na le Chefo, tlhokomelo e tlameha ho lefshoa ts'ebetsong. Ka kakaretso, 1 ~ 5mg ea phenylmercury acetate e ka ekeletsoa ho tharollo ka litha e le nngwe ea tekanyo.
(8) Ts'ebetso eahydroxypropyl methylcellulosefilimi Hydroxypropyl methylcellulose e na le thepa e ntle haholo ea ho etsa lifilimi. Tharollo ea eona e nang le metsi kapa motsoako oa motsoako oa tlhaho o koahetsoe holim'a poleiti ea khalase, 'me e fetoha e se nang mebala le e hlakileng ka mor'a ho omisa. Le filimi e thata. E na le khanyetso e ntle ea mongobo 'me e lula e tiile mocheso o phahameng. Haeba hygroscopic plasticizer e eketsoa, bolelele ba eona le ho tenyetseha ha eona ho ka ntlafatsoa. Mabapi le ho ntlafatsa ho feto-fetoha ha maemo, li-plasticizers tse kang glycerin le sorbitol ke tsona tse loketseng ka ho fetisisa. Ka kakaretso, mahloriso a tharollo ke 2% ~ 3%, 'me palo ea plasticizer ke 10% ~ 20% ea cellulose ether. Haeba litaba tsa plasticizer li phahame haholo, ho fokotseha ha colloidal dehydration ho tla etsahala ka mongobo o phahameng. Matla a thata a filimi e nang le polasetiki e kenyelletsoeng e kholoanyane ho feta e se nang polasetiki, 'me e eketseha ka ho eketseha ha palo e eketsehileng. Ha e le hygroscopicity ea filimi, e boetse e eketseha ka keketseho ea palo ea polasetiki.
Nako ea poso: Apr-25-2024