Litšobotsi tsa theknoloji e phahameng ea mocheso bakeng sa hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC)ke lisebelisoa tsa bohlokoa tsa lik'hemik'hale, tse sebelisoang haholo linthong tsa mohaho, meriana, lijo le masimo a mang. Haholo-holo indastering ea kaho, HPMC e sebelisoa haholo ka lebaka la ts'ebetso ea eona e ntle haholo. Theknoloji ea mocheso o phahameng o bapala karolo ea bohlokoa tlhahisong le ts'ebetsong ea HPMC.

1. Karolo ea thekenoloji ea mocheso o phahameng ho HPMC

tlhahisoHydroxypropyl methylcellulose e fumanoa ka letoto la liketso tsa lik'hemik'hale tse kang alkalization le etherification ea cellulose ea tlhaho. Theknoloji e phahameng ea mocheso e sebelisoa haholo-holo mekhahlelong ea ho qhibiliha, ho omisa le ho bopa ea mokhoa oa ho itšoara. Phekolo e phahameng ea mocheso e ke ke ea potlakisa sekhahla sa karabelo feela, empa hape e ntlafatsa bohloeki le botsitso ba sehlahisoa.

Ntlafatso ea karabelo e sebetsang hantle

Tlas'a maemo a mocheso o phahameng, sekhahla sa karabelo ea selulose le sodium hydroxide e potlakisa, e khothalletsang hydroxypropyl le methyl substitution reaction ka har'a limolek'hule tsa cellulose, ka hona ho ntlafatsa tekanyo ea substitution (DS) le ho ts'oana ha HPMC.

Tlosa litšila

Tikoloho e phahameng ea mocheso e ka tlosa ka katleho lihlahisoa tse hlahisoang nakong ea karabelo, joalo ka tharollo ea alkali e sa sebetseng le mokelikeli, le ho ntlafatsa bohloeki ba HPMC.

Matla a ho omisa a ntlafetseng

Nakong ea ts'ebetso ea ho omisa mocheso o phahameng, mongobo oa HPMC o fetoha mouoane ka potlako, o qoba sehlahisoa ho tloha ho agglomerating kapa denaturing ka mocheso o tlase, le ho ntlafatsa ts'ebetso ea botsitso le polokelo ea sehlahisoa.

2. Tšusumetso ea theknoloji ea mocheso o phahameng mosebetsing oa HPMC

Theknoloji e phahameng ea mocheso ha e ame feela sebopeho sa 'mele sa HPMC, empa e boetse e na le tšusumetso e kholo ho lik'hemik'hale tsa eona tsa lik'hemik'hale le liphello tsa kopo.

Tokiso ea viscosity

Ts'ebetso e phahameng ea mocheso e ka laola ka nepo ho tsamaisoa ha boima ba limolek'hule tsa HPMC, ka hona ho fetola viscosity ea eona. Lithempereichara tse phahameng li thusa ho fokotsa monyetla oa ho phatloha ha ketane ea limolek'hule, ho etsa hore viscosity ea HPMC ka tharollo ea metsi e be e tsitsitseng haholoanyane.

Ho hanyetsa mocheso o matlafalitsoeng

Ho tsitsa ha mocheso oa HPMC ho ntlafatsoa haholo ka phekolo ea mocheso o phahameng. Ho haha ​​​​likhomaretsi tsa seretse le lithaele, HPMC e ntse e ka boloka thepa e ntle ea ho khomarela le ho thibela ho theoha tlas'a maemo a phahameng a mocheso.

Solubility e ntlafalitsoeng

Nakong ea ts'ebetso ea ho omisa mocheso o phahameng, microstructure ea HPMC e ntlafalitsoe, e etsa hore e qhibilihe haholoanyane metsing a batang. Haholo-holo libakeng tsa kaho tse nang le mocheso o tlase, HPMC e ka qhibiliha ka potlako 'me ea etsa tharollo e tšoanang ea colloidal.

3. Tšebeliso e khethehileng ea theknoloji ea mocheso o phahameng ka mokhoa oa tlhahiso ea HPMC

Etherification reaction stage

Ka ho etsa karabelo ea etherification mochesong o phahameng oa 80-100 ° C, karabelo ea sebaka sa hydroxypropyl le lihlopha tsa methyl e ka potlakisoa, e le hore HPMC e be le boemo bo phahameng ba phapanyetso le botsitso bo betere.

Sethala sa ho omisa le ho senya

Theknoloji ea ho omisa moea o chesang ka holimo ho 120 ° C e ke ke ea tlosa mongobo feela, empa hape e thibela phofo ea HPMC hore e se ke ea kopana nakong ea ho omisa. Ka mor'a moo, theknoloji ea ho senya mocheso o phahameng e sebelisoa ho etsa hore likaroloana tsa phofo tsa HPMC li be bonolo le ho lekana, 'me ho senyeha ha sehlahisoa ho ntlafatsoa.

Mocheso o phahameng oa phekolo ea phekolo

Ha HPMC e sebelisoa ka thepa ea mohaho kapa liphahlo, phekolo e phahameng ea mocheso oa mocheso e ka ntlafatsa ho hanyetsa ha eona, ho hanyetsa le ho boloka metsi, ho netefatsa phello e ntle ea kaho libakeng tse thata.

4. Melemo ea theknoloji e phahameng ea mocheso masimong a kopo ea HPMC

Lisebelisoa tsa ho haha

Tlas'a tikoloho ea mocheso o phahameng, HPMC e bonts'a ho teteka ho hoholo le ho boloka metsi ka har'a seretse le phofo ea putty, ho thibela seretse ho tsoa ka potlako le ho phatloha.

Indasteri ea pente

HPMC e entsoeng ka mocheso o phahameng e na le litlamorao tse ntle tsa ho tsitsa le ho thibela ho sisinyeha ka pente ea latex, e ntlafatsang ho khomarela le ho roala ha seaparo.

Indasteri ea meriana

Theknoloji e phahameng ea mocheso e ka ntlafatsa ho tšoana ha HPMC ka ho roala lithethefatsi le ho netefatsa botsitso ba phello e tsitsitseng ea ho lokolloa ha lithethefatsi.

Tšebeliso ea theknoloji ea mocheso o phahameng oahydroxypropyl methylcelluloseha e ntlafatse ts'ebetso ea tlhahiso feela, empa hape e ntlafatsa ts'ebetso ea sehlahisoa. Ka ts'ebetso e phahameng ea mocheso, viscosity, solubility le botsitso ba mocheso oa HPMC li ntlafalitsoe haholo, ho etsa hore e be le tebello e pharaletseng ea ts'ebeliso litabeng tsa kaho, liphahlo le meriana. Nakong e tlang, ka tsoelo-pele e tsoelang pele ea thekenoloji ea mocheso o phahameng, ts'ebetso ea HPMC e tla ntlafatsoa le ho feta, e tla fana ka menehelo e kholo ho nts'etsopele ea lisebelisoa tse tala le tse sireletsang tikoloho.