1. Selelekela
Hydroxypropyl methylcellulose (HPMC) ke motsoako oa bohlokoa oa selulose oa maiketsetso o sebelisoang haholo ho thepa ea mohaho, litokisetso tsa meriana, li-additives tsa lijo le litlolo. Tšebeliso e ntle ea metsi ke e 'ngoe ea litšobotsi tsa bohlokoa tsa ts'ebeliso e pharaletseng ea HPMC.
2. Sebopeho le thepa ea HPMC
2.1 Sebopeho sa lik'hemik'hale
HPMC ke semi-synthetic cellulose ether. Li-substituent tsa hydroxypropyl le methyl sebopeho sa lik'hemik'hale li e fa matla a ikhethang a ho qhibiliha le thepa ea colloidal. Sebopeho sa motheo sa HPMC se na le liketane tsa β-D-glucose tsa selulose, moo lihlopha tse ling tsa hydroxyl li nkeloang sebaka ke lihlopha tsa methyl le hydroxypropyl. Boemo le tekanyo ea ho kenya sebaka sa li-substitute tsena ka ho toba li ama ho solubility, viscosity le ho boloka metsi a HPMC.
2.2 Thepa ea 'mele
Ho qhibiliha ha metsi: HPMC e qhibiliha habonolo metsing a batang 'me e etsa tharollo ea colloidal metsing a chesang.
Thepa e teteaneng: E ka etsa tharollo ea viscous ka metsing 'me e na le phello e ntle ea ho teteana.
Thepa ea ho etsa lifilimi: E ka etsa filimi e bonaletsang le e otlolohileng.
Suspension: E na le ts'ebetso e ntle ea ho emisa tharollo 'me e ka tsitsisa taba e emisitsoeng.
3. Ho boloka metsi a HPMC
3.1 Mokhoa oa ho boloka metsi
Ho bolokoa ha metsi ha HPMC ho hlahisoa haholo ke tšebelisano lipakeng tsa hydroxyl le lihlopha tse ling ka sebopeho sa eona sa limolek'hule le limolek'hule tsa metsi. Ka ho khetheha, HPMC e boloka metsi ka mekhoa e latelang:
Hydrogen bonding: Lihlopha tsa hydroxyl ka har'a limolek'hule tsa HPMC li theha likamano tsa haedrojene ka limolek'hule tsa metsi. Matla ana a thusa limolek'hule tsa metsi hore li tlameletsoe ka thata ho pota-pota HPMC, ho fokotsa mouoane oa metsi.
Phello e phahameng ea viscosity: Tharollo e phahameng ea viscosity e entsoeng ke HPMC ka metsing e ka sitisa ho tsamaea ha metsi, kahoo e fokotsa tahlehelo ea metsi.
Sebopeho sa marang-rang: Sebopeho sa marang-rang se entsoeng ke HPMC ka metsing se ka tšoara le ho boloka limolek'hule tsa metsi, e le hore metsi a aroloe ka mokhoa o lekanang mohahong oa marang-rang.
Colloid effect: The colloid e entsoeng ke HPMC e ka koala metsi ka hare ho colloid le ho eketsa nako ea ho boloka metsi.
3.2 Lintlha tse amang ho boloka metsi
Degree of substitution: Palo ea metsi ea HPMC e angoa ke degree of substitution (DS). Ha tekanyo ea ho fetola e phahame, ho ba matla ha hydrophilicity ea HPMC le ho ntlafatsa ts'ebetso ea eona ea ho boloka metsi.
Boima ba molek'hule: Boima bo phahameng ba limolek'hule bo thusa ho theha marang-rang a matla a ketane ea limolek'hule, ka hona ho ntlafatsa ho boloka metsi.
Tekanyo: Motsoako oa tharollo ea HPMC o na le phello e kholo ho bolokeng metsi. Litharollo tse phahameng haholo li khona ho etsa litharollo tse ngata tsa viscous le mekhoa e tsitsitseng ea marang-rang, kahoo e boloka metsi a mangata.
Mocheso: Palo ea metsi ea HPMC e fapana ho ea ka mocheso. Ha mocheso o phahama, viscosity ea tharollo ea HPMC e fokotseha, e leng se fellang ka ho fokotseha ha ho boloka metsi.
4. Tšebeliso ea HPMC mafapheng a fapaneng
4.1 Lisebelisoa tsa ho haha
Lisebelisoa tsa moaho, HPMC e sebelisoa e le se bolokang metsi bakeng sa samente le lihlahisoa tse thehiloeng ho gypsum. Mesebetsi ea eona ea mantlha e kenyelletsa:
Ntlafatsa ts'ebetso ea kaho: Ka ho boloka mongobo o lekaneng, nako e bulehileng ea samente le gypsum e atolosoa, e leng ho etsang hore mosebetsi oa kaho o be bonolo.
Fokotsa mapetsong: Ho boloka metsi hantle ho thusa ho fokotsa mapetsong a hlahisoang nakong ea ho omisa le ho ntlafatsa matla le ho tšoarella ha thepa ea ho qetela.
Ntlafatsa matla a tlamo: Likhomaretsing tsa lithaele, HPMC e ka eketsa matla a bond le ho ntlafatsa phello ea tlamahano.
4.2 Litokisetso tsa meriana
Litokisetsong tsa meriana, ho bolokoa ha metsi ha HPMC ho phetha karolo ea bohlokoa tokollong le botsitsong ba lithethefatsi:
Litokisetso tsa tokollo e tsitsitseng: HPMC e ka sebelisoa e le mokhoa o tsitsitseng oa tokollo bakeng sa lithethefatsi ho fihlela tokollo e tsitsitseng ea lithethefatsi ka ho laola ho kenella ha metsi le sekhahla sa ho qhalana ha lithethefatsi.
Litlhare le li-binders: Litlhare le matlapa a metsi, HPMC e sebetsa e le sekontiri le se tlamang ho boloka botsitso le botsitso ba lithethefatsi.
4.3 Lisebelisoa tsa lijo
Indastering ea lijo, HPMC e sebetsa joalo ka setenya le se tsitsitseng, 'me ho boloka metsi ho sebelisetsoa:
Ho ntlafatsa tatso: Ka ho boloka metsi, HPMC e ka ntlafatsa sebopeho le tatso ea lijo, ea etsa hore e be mafura le ho ba monate.
Ho eketsa bophelo ba lishelefo: Ka ho boloka metsi, HPMC e ka thibela tahlehelo ea metsi nakong ea polokelo, ka tsela eo e lelefatsa bophelo ba sethala.
4.4 Litlolo
Ho litlolo, ho boloka metsi ha HPMC ho sebelisetsoa:
Phello ea mongobo: Joaloka moisturizer, HPMC e ka thusa ho koala mongobo holim'a letlalo le ho fana ka phello ea nako e telele ea mongobo.
Ho tsitsisa ho emisoa: Ka li-emulsions le li-suspensions, HPMC e tsitsisa sehlahisoa mme e thibela stratification le sedimentation.
Ho boloka metsi ha HPMC ho etsa hore e be lisebelisoa tsa bohlokoa tse sebetsang mafapheng a mangata. E boloka metsi 'me e fokotsa mouoane oa metsi ka ho kopanya hydrogen, liphello tse phahameng tsa viscosity, sebopeho sa marang-rang le liphello tsa colloid. Ho boloka metsi ho angoa ke tekanyo ea phetoho, boima ba limolek'hule, mahloriso le mocheso, tse khethollang ts'ebetso ea HPMC ts'ebetsong e itseng. Ebang ke thepa ea ho haha, litokisetso tsa meriana, li-additives tsa lijo kapa litlolo, ho boloka metsi a HPMC ho phetha karolo ea bohlokoa ho ntlafatsa boleng le ts'ebetso ea sehlahisoa.
Nako ea poso: Jun-26-2024