Ndezvipi zvakaipira HPMC?

Hydroxypropyl methylcellulose (HPMC)chinhu chakajairika chemakemikari chinoshandiswa zvakanyanya mumaindasitiri mazhinji akadai sekuvaka, mishonga, chikafu uye zvizorwa. Nekudaro, kunyangwe HPMC iine akawanda akanakisa zvivakwa, zvakaita sekukora, emulsification, kuumbwa kwemafirimu, uye yakagadzikana masisitimu ekumisikidza, inewo zvimwe zvayakaipira uye zvinogumira.

1. Solubility issues

Kunyangwe HPMC inogona kunyungudika mumvura uye zvimwe organic zvinonyungudutsa, solubility yayo inokanganisa tembiricha. Iyo inonyungudika zvishoma nezvishoma mumvura inotonhora uye inoda kukwana kwakakwana kuti iparadze zvachose, nepo inogona kuumba gel mumvura inotonhora zvikuru, ichiita kuti ipararire zvisina kufanana. Hunhu uhu hunogona kuunza kumwe kusagadzikana kune mamwe mamiriro ekushandisa (senge zvekuvakisa nemishonga), uye yakakosha kunyungudutswa kana zvinowedzerwa zvinodikanwa kukwirisa mhedzisiro yekuparara.

2. Mutengo wepamusoro

Kuenzaniswa nemamwe echisikigo kana ekugadzira thickeners, mutengo wekugadzira weHPMC wakakwira. Nekuda kwemaitiro ayo akaomarara ekugadzirira, ayo anosanganisira akawanda matanho senge etherification uye kucheneswa, mutengo wayo wakakwira kupfuura mamwe makobvu, akadai sehydroxyethyl cellulose (HEC) kana carboxymethyl cellulose (CMC). Kana ikashandiswa pamwero mukuru, zvinhu zvinodhura zvinogona kuva chikonzero chakakosha chekudzikisa kushandiswa kwayo.

3. Inobatwa nepH kukosha

HPMC ine kugadzikana kwakanaka pasi penzvimbo dzakasiyana dzepH, asi inogona kudzikisira pasi peyakanyanya pH mamiriro (senge yakasimba asidhi kana hwaro hwakasimba), zvichikanganisa kukora uye kudzikamisa mhedzisiro. Naizvozvo, kushanda kweHPMC kunogona kushomeka mune mamwe mamiriro ekushandisa anoda yakanyanyisa pH mamiriro (seyakakosha kemikari reaction system).

4. Kuderera kwebiodegradability

Kunyange zvazvo HPMC ichionekwa sechinhu chine hushamwari kwezvakatipoteredza, ichiri kutora nguva yakareba kuti inyatso kuomeswa. Munzvimbo yechisikigo, mwero wekushatisa weHPMC unononoka, izvo zvinogona kuve nemhedzisiro pane ecological nharaunda. Kune maapplication ane yakakwira kuchengetedzwa kwezvakatipoteredza zvinodiwa, kudzikira kweHPMC kungasava sarudzo yakanyanya kunaka.

5. Low mechanical simba

Kana HPMC inoshandiswa sechinhu chemufirimu kana gel, simba rayo remagetsi rakaderera uye zviri nyore kuputsa kana kukuvadza. Semuenzaniso, muindasitiri yemishonga, apo HPMC inoshandiswa kugadzira capsules, ine kusimba kwakashata kana ichienzaniswa negelatin capsules, uye dambudziko rekushaya simba rinogona kukanganisa kugadzikana kwekutakura uye kuchengetedza. Muindasitiri yekuvaka, kana HPMC ichishandiswa seyakakora, kunyangwe ichigona kuvandudza kunamatira kwedhaka, ine mupiro wakakwana kune simba remagetsi rechigadzirwa chekupedzisira.

6. Hygroscopicity

HPMC ine imwe dhigirii ye hygroscopicity uye inotora unyoro nyore munzvimbo yakakwirira yehunyoro, iyo inogona kukanganisa kushanda kwayo. Semuenzaniso, mukugadzirira kwechikafu kana zvinodhaka, kunyudza hunyoro kunogona kukonzera kupfava kwehwendefa uye shanduko mukuparara kwekuita, zvichikanganisa kugadzikana kwechigadzirwa. Nokudaro, panguva yekuchengetedza uye kushandiswa, hunyoro hwezvakatipoteredza hunoda kudzorwa kudzivirira kushanda kwayo kubva pakuipa.

7. Mhedzisiro pane bioavailability

Muindasitiri yemishonga, HPMC inowanzo shandiswa kugadzirira kuburitswa-kuburitswa kana kudzorwa-kuburitsa mahwendefa, asi zvinogona kukanganisa kuburitswa kwemamwe mishonga. Semuenzaniso, kune hydrophobic zvinodhaka, kuvapo kweHPMC kunogona kuderedza kuparara kwemushonga mumuviri, zvichikanganisa bioavailability yayo. Naizvozvo, pakugadzira magadzirirwo emishonga, mhedzisiro yeHPMC pakuburitswa kwezvinodhaka inoda kunyatsoongororwa, uye zvimwe zvekuwedzera zvinogona kudikanwa kuti kuwedzere kushanda kwezvinodhaka.

8. Thermal kugadzikana

HPMC inogona kudzikisira kana kuchinja mukuita pane tembiricha yepamusoro. Kunyange zvazvo HPMC yakanyatsogadzikana muhuwandu hwekushisa, inogona kuderedza, kubvisa ruvara, kana kukanganisa mukushanda pakupisa kwepamusoro kunodarika 200 ° C, iyo inomisa kushandiswa kwayo mukupisa kwepamusoro. Semuyenzaniso, mune mamwe mapurasitiki kana rabha kugadzirisa, HPMC isingakwane kupisa kwekudzivirira kunogona kukonzera kudzikira kwemhando yechigadzirwa.

9. Nyaya dzekuenderana nezvimwe zvinhu

Mukugadzira maapplication, HPMC inogona kuita zvakashata nemamwe ma cationic surfactants kana chaiwo maion simbi, zvichikonzera turbidity kana coagulation yemhinduro. Iyi nyaya yekuenderana inogona kukanganisa kunaka uye kutaridzika kwechigadzirwa chekupedzisira mune mamwe maapplication (sezvekuzora, mishonga yemishonga kana kemikari mhinduro), inoda kuyedzwa kuenderana uye kugadzirisa kwekugadzirisa.

NyangweHPMCchinhu chinoshandiswa nevakawanda chinoshanda chine kukora kwakanakisa, kugadzira firimu uye kudzikamisa mhedzisiro, zvakare ine zvayakaipira sekunyungudika kushoma, kudhura kwakanyanya, kushomeka kwebiodegradability, kuderera kwemagetsi simba, yakasimba hygroscopicity, kukanganisa pakuburitswa kwezvinodhaka, uye kushomeka kwekupisa. Izvi zvinogumira zvinogona kukanganisa kushandiswa kweHPMC mune mamwe maindasitiri chaiwo. Naizvozvo, pakusarudza HPMC seyakagadzirwa zvinhu, zvinodikanwa kunyatso funga zvakanakira nezvayakaipira uye nekuigadzirisa pamwe chete nezvido zvekushandisa.