Hydroxypropyl Methylcellulose (HPMC)ipolymer inonyungudika nemvura inowanzoshandiswa mumaindasitiri emishonga, zvekuzora uye zvekudya. Nekuda kwekunakisa kunyungudika kwemvura uye viscosity gadziriso zvivakwa, HPMC inoshandiswa zvakanyanya mumagel, zvinodhaka zvinodzorwa kuburitsa dosage mafomu, kumiswa, thickeners uye mamwe minda. Mhando dzakasiyana uye zvirevo zveHPMC zvine tembiricha dzakasiyana siyana, kunyanya kana uchigadzirira HPMC gels, tembiricha ine simba rakakosha pane solubility yayo, viscosity uye kugadzikana.
HPMC kuparara uye gel kuumbwa tembiricha renji
Dissolution tembiricha
HPMC inowanzonyungudika mumvura nemvura inopisa, uye tembiricha yekunyungudika inoenderana nehuremu hwayo hwemamorekuru uye dhigirii remethylation uye hydroxypropylation. Kazhinji kutaura, tembiricha yekunyungudika yeHPMC inotangira pa70 ° C kusvika 90 ° C, uye tembiricha yekunyungudika inokanganiswa neiyo HPMC uye kusangana kwemhinduro. Semuenzaniso, yakaderera-viscosity HPMC inowanzonyungudika pane yakaderera tembiricha (inenge 70 ° C), nepo high-viscosity HPMC ingada tembiricha yepamusoro (pedyo ne90 ° C) kuti inyunguduke zvachose.
Gel Formation Temperature (Gelation Temperature)
HPMC ine yakasarudzika thermoreversible gel pfuma, ndiko kuti, ichagadzira gel mukati meimwe tembiricha renji. Iyo tembiricha yemhando yeHPMC gel inonyanya kukanganiswa nehuremu hwayo hwemamorekuru, chimiro chemakemikari, kugadzirisa kugadzirisa uye zvimwe zvinowedzera. Kazhinji, tembiricha yemhando yeHPMC gel inowanzoita 35°C kusvika 60°C. Mukati meiyi chiyero, iyo HPMC mamorekuru cheni inozoronga patsva kuti iite matatu-dimensional network chimiro, zvichiita kuti mhinduro ichinje kubva kumvura kuenda kune gel state.
Iyo chaiyo yekugadzira gel tembiricha (kureva, tembiricha yegelation) inogona kutsanangurwa mukuyedza. Iyo tembiricha yegelation yeHPMC gel inowanzoenderana nezvinhu zvinotevera:
Molecular uremu: HPMC ine yakakwira molecular uremu inogona kugadzira gel pane yakaderera tembiricha.
Kugadziriswa kwekugadzirisa: Kukwirira kwekugadzirisa kwekugadzirisa, kuderera kwekushisa kwekugadzira gel kunowanzo.
Dhigirii remethylation uye dhigirii rehydroxypropylation: HPMC ine yakakwira dhigirii yemethylation kazhinji inoumba gel pane yakaderera tembiricha nekuti methylation inowedzera kudyidzana pakati pemamorekuru.
Mhedzisiro yekushisa
Mumashandisirwo anoshanda, tembiricha ine mhedzisiro yakakosha pakuita uye kugadzikana kweHPMC gel. Kupisa kwepamusoro kunowedzera kuyerera kweHPMC molecular cheni, nekudaro kukanganisa kusimba uye kunyungudika kweiyo gel. Pane zvinopesana, tembiricha yakaderera inogona kunetesa hydration yeHPMC gel uye kuita kuti chimiro chegel chisagadzikana. Uye zvakare, shanduko yetembiricha inogonawo kukonzera kusangana pakati peHPMC mamorekuru uye shanduko mune viscosity yemhinduro.
HPMC gelation maitiro pane akasiyana pH uye ionic simba
Iyo gelation maitiro eHPMC anokanganisa kwete chete nekushisa, asiwo ne pH uye mhinduro ionic simba. Semuenzaniso, iyo solubility uye gelation maitiro eHPMC pane akasiyana pH kukosha ichave yakasiyana. Kunyungudika kweHPMC kunogona kudzikiswa munzvimbo dzine acidic, nepo kunyungudika kwayo kungawedzerwa munzvimbo dzine alkaline. Saizvozvowo, kuwedzera kweionic simba (zvakadai sekuwedzera kwemunyu) kuchakanganisa kuwirirana pakati pe HPMC molecules, nokudaro kuchinja kuumbwa uye kugadzikana kwejeri.
Kushandiswa kweHPMC gel uye tembiricha yayo maitiro
Iyo tembiricha maitiro eHPMC gel anoita kuti ishandiswe zvakanyanya mukuburitswa kwezvinodhaka, kugadzirira zvekuzora uye mamwe minda:
Kusunungurwa kwezvinodhaka kunodzorwa
Mukugadzirira zvinodhaka, HPMC inowanzoshandiswa seyakadzorwa kuburitsa matrix, uye yayo gelation zvimiro zvinoshandiswa kudzora kuburitswa kwezvinodhaka. Nekugadzirisa kusungirirwa uye tembiricha yegelation yeHPMC, kuburitswa kwemishonga kunogona kunyatsodzorwa. Kuchinja kwekushisa kwemishonga mugumbo remudumbu kunogona kukurudzira kuzvimba kweHPMC gel uye kusunungurwa zvishoma nezvishoma kwemishonga.
Cosmetics uye Personal Care Zvigadzirwa
HPMC inowanzoshandiswa muzvizoro zvakadai semafuta ekuzora, gels, vhudzi rekupfapfaidza, uye mafuta eganda. Nekuda kwekunzwa kwayo tembiricha, HPMC inogona kugadzirisa magadzirirwo uye kugadzikana kwezvigadzirwa pasi pemamiriro ekushisa akasiyana. Shanduko yetembiricha mukuumbwa kwecosmetic ine mhedzisiro yakakosha pane gelation maitiro eHPMC, saka iyo yakakodzera HPMC yakatarwa inoda kunyatsosarudzwa paunenge uchigadzira zvigadzirwa.
Indasitiri Yezvokudya
Muchikafu, HPMC inoshandiswa zvakanyanya seyakakora uye emulsifier, kunyanya mukugadzirira-kudya-kudya uye zvinwiwa. Hunhu hwayo husinganzwi tembiricha hunoita kuti HPMC ichinje chimiro chayo panguva yekudziya kana kutonhora, nekudaro ichikanganisa kuravira uye chimiro chechikafu.
The tembiricha zvinhu zveHPMCgels chinhu chakakosha mukushandisa kwavo. Nekugadzirisa tembiricha, kutarisisa, uye kugadziridzwa kwemakemikari, zvimiro zveHPMC gels, senge solubility, gel simba, uye kugadzikana, inogona kunyatso dzorwa. Tembiricha yekugadzira gel kazhinji iri pakati pe35°C ne60°C, ukuwo tembiricha yekunyunguduka kwayo iri 70°C kusvika 90°C. HPMC inoshandiswa zvakanyanya mumaindasitiri emishonga, zvekuzora, uye zvekudya nekuda kweiyo yakasarudzika thermoreversible gelation maitiro uye tembiricha senitivity.
Nguva yekutumira: Jan-16-2025