Hydroxypropyl Methylcellulose (HPMC)musanganiswa wepolymer unonyungudika nemvura unowanikwa nemakemikari anogadzirisa selulosi chaiwo. Inonyanya kushandiswa muminda yemishonga, chikafu, cosmetics, uye kuvaka, uye ine yakanakisa zvivakwa zvakaita sekukora, kugadzira firimu, emulsification, uye kugadzikana.
1. Nheyo yekugadzirira
Hydroxypropyl methylcellulose ndeye hydrophilic cellulose derivative, uye kunyungudika kwayo kunonyanya kukanganiswa neiyo hydroxypropyl uye methyl substituents mumorekuru. Iro methyl boka rinowedzera kunyungudika kwemvura, nepo boka re hydroxypropyl rinowedzera kunyungudika kwayo mumvura. Kazhinji, AnxinCel®HPMC inogona kunyungudika nekukurumidza mumvura inotonhora kuti iite yunifomu colloidal solution, asi inonyungudika zvishoma nezvishoma mumvura inopisa, uye zvinhu zvegranular zvinowanzosangana panguva yekunyungudika. Naizvozvo, kutarisisa kunofanirwa kubhadharwa pakudzora tembiricha yekunyungudika uye nzira yekunyungudika panguva yekugadzirira.
2. Kugadzirira kwezvinhu
HPMC poda: Sarudza HPMC poda ine viscosities yakasiyana uye madhigirii ekutsiva maererano nezvinodiwa zvekushandisa. Mienzaniso yakajairika inosanganisira yakaderera viscosity (yakaderera molecular uremu) uye yakakwirira viscosity (yakakwira molecular uremu). Kusarudzwa kunofanirwa kuve kwakavakirwa pane zvinodiwa zveiyo chaiyo yekuumbwa.
Solvent: Mvura ndiyo inonyanya kushandiswa, kunyanya mukushandiswa kwemishonga uye chikafu. Zvinoenderana nezvinodiwa zvekuparara, musanganiswa wemvura uye organic solvents, senge ethanol / mvura yakasanganiswa mhinduro, inogona kushandiswa zvakare.
3. Kugadzirira nzira
Kuyera HPMC
Kutanga, kunyatsoyera inodiwa HPMC powder maererano nehuwandu hwekugadzirisa kugadzirirwa. Kazhinji, huwandu hwehuwandu hweHPMC ndeye 0.5% kusvika 10%, asi iyo yakatarwa inofanirwa kugadziridzwa zvichienderana nechinangwa uye inodiwa viscosity.
Pre-wetting dissolution
Kuti udzivise HPMC poda kubva kuagglomerating, pre-wetting dissolution inowanzogamuchirwa. Iyo chaiyo mashandiro ndeiyi: mwaya yakayerwa HPMC hupfu zvakaenzana muchikamu chezvinonyungudutsa, kurunga zvinyoro nyoro, uye ita kuti HPMC hupfu ibatane nekashoma kekunyungudika kutanga kuita hunyoro. Izvi zvinogona kudzivirira zvinobudirira iyo HPMC poda kubva kuagglomerating uye kukurudzira kwayo yunifomu kupararira.
Dissolution process
Zvishoma nezvishoma wedzera solvent yasara kune yakanyorova HPMC poda uye ramba uchikurudzira. Sezvo HPMC ine mvura yakanaka solubility, mvura uye HPMC nyungudika nokukurumidza pakamuri tembiricha. Dzivisa kushandisa simba rekugera rakawandisa paunenge uchimutsa, nekuti kubvongodza kwakasimba kunokonzeresa mabhubhu kuti aumbe, zvichikanganisa kujeka uye kufanana kwemhinduro. Muzhinji, iyo inomhanyisa kumhanya inofanirwa kuchengetwa padanho rakaderera kuti ive nechokwadi chekuparara kweyunifomu.
Kudzora tembiricha
Kunyange zvazvo HPMC inogona kunyungudutswa mumvura inotonhora, kana chiyero chekupera chichinonoka, mhinduro inogona kupiswa zvakakodzera. Kupisa kwekushisa kunofanirwa kudzorwa pakati pe40 ° C uye 50 ° C kudzivirira yakanyanya kupisa tembiricha inokonzera shanduko muchimiro chemolecular kana shanduko dzakapinza mumhinduro viscosity. Munguva yekupisa, kubvongodza kunofanirwa kuenderera mberi kusvika HPMC yanyungudika zvachose.
Kutonhodza uye kusefa
Mushure mekupera zvachose, bvumira mhinduro kuti itonhorere zvakasununguka kusvika kune tembiricha yekamuri. Munguva yekutonhodza, diki diki mabhubhu kana tsvina inogona kuoneka mune mhinduro. Kana zvichidikanwa, sefa inogona kushandiswa kuisefa kuti ibvise zvimedu zvakasimba uye ive nechokwadi chekujeka uye pachena kwemhinduro.
Kugadzirisa kwekupedzisira uye kuchengetedza
Mushure mokunge mhinduro yacho yatonhodzwa, kuisa kwayo kunogona kugadziriswa maererano nezvinodiwa chaizvo. Kana iyo yekuisa yakanyanya kuwanda, solvent inogona kuwedzerwa kuidzikisa; kana iyo yakasungwa yakanyanya kuderera, yakawanda HPMC poda inoda kuwedzerwa. Mushure mekugadzirisa kugadziriswa, inofanira kushandiswa pakarepo. Kana ichida kuchengetwa kwenguva yakareba, inofanira kuchengetwa mumudziyo wakavharwa kudzivirira kubuda kwemvura kana kusvibiswa kwemhinduro.
4. Chengetedzo
Kudzora tembiricha: Kupisa kwakanyanya kunofanirwa kudzivirirwa panguva yekunyungudika kudzivirira kukanganisa kunyungudika uye kuita kweAnxinCel®HPMC. Pakupisa kwakanyanya, HPMC inogona kuderedza kana viscosity yayo inogona kuderera, zvichikanganisa mashandisiro ayo.
Stiring method: Dzivisa kugera kwakanyanyisa kana kukurumidza kubvongodza spidhi panguva yekurunga, nekuti kubvongodza kwakasimba kunogona kukonzera mabhuru kuumba uye kukanganisa kujeka kwemushonga.
Sarudzo yekunyungudutsa: Mvura ndiyo inonyanya kushandiswa kunyungudutsa, asi mune mamwe maapplication akakosha, mhinduro yakasanganiswa yemvura uye zvimwe zvinonyungudutsa (zvakadai sedoro, acetone, nezvimwewo) zvinogona kusarudzwa. Yakasiyana solvent ratios ichakanganisa chiyero chekuparara uye kuita kwemhinduro.
Mamiriro ekuchengetedza: Yakagadzirirwa HPMC mhinduro inofanirwa kuchengetwa munzvimbo inotonhorera uye yakaoma kudzivirira kuratidzwa kwenguva refu kune tembiricha yepamusoro kana zuva rakananga kudzivirira shanduko mumhando yemhinduro.
Anti-caking: Kana poda yakawedzerwa kune yakanyungudutsa, kana pfumbu yakawedzerwa nokukurumidza kana kuti isina kuenzana, zviri nyore kuumba mapundu, saka inofanira kuwedzerwa zvishoma nezvishoma.
5. Minda yekushandisa
Hydroxypropyl methylcellulose inoshandiswa zvakanyanya mumaindasitiri akasiyana nekuda kwekunakisa kunyungudika kwemvura uye biocompatibility:
Indasitiri yemishonga: Seyaimbova firimu, adhesive, thickener, inosimudzira-kusunungurwa agent, nezvimwewo zvemishonga, inoita basa rinokosha mukugadzirira kwemishonga.
Indasitiri yechikafu: Seyakakora, emulsifier, stabilizer, inowanzoshandiswa mukugadzira chikafu, senge ice cream, condiments, zvinwiwa, nezvimwe.
Indasitiri yekuvaka: Semukobvu wekugadzira machira uye dhaka, inogona kuvandudza kunamatira uye fluidity yemusanganiswa.
Cosmetics: Seyakakora, stabilizer uye firimu rekare, rinoshandiswa muzvizoro zvakadai semafuta, shampoos, uye zvigadzirwa zvekuchengetedza ganda kuvandudza mhando yechigadzirwa uye ruzivo rwemushandisi.
Kugadzirira kweHPMCinzira inoda kutariswa kune zvakadzama. Panguva yekugadzirira, zvinhu zvakadai sekushisa, nzira yekukurudzira, uye kusarudzwa kwezvinonyungudutsa zvinoda kudzorwa kuti zvive nechokwadi chokuti inogona kunyungudutswa zvakakwana uye kuchengetedza kushanda kwakanaka. Kuburikidza nenzira kwayo yekugadzirira, AnxinCel®HPMC inogona kushandiswa zvakanyanya mumaindasitiri akawanda uye kuita basa rayo rakakosha.
Nguva yekutumira: Jan-16-2025