Hydroxypropyl Methylcellulose (HPMC)ose ituaiga fa'afoma'i fa'afoma'i o le cellulose e fa'aaogaina lautele i le tele o alamanuia e pei o vaila'au, gaosiga o mea'ai, ma faufale. O se mea faʻapipiʻi tele, e masani ona faʻaaogaina e avea o se mafiafia, faʻapipiʻi, mea e fai ata tifaga, ma faʻamautu. Ae ui i lea, e leai se "numera faʻasologa" faʻapitoa i le uiga masani, e pei o se oloa poʻo se vaega numera e mafai ona e mauaina i isi tulaga gaosiga. Nai lo lena, o le HPMC o loʻo faʻaalia i lona fausaga vailaʻau ma le tele o uiga, e pei o le tikeri o le sui ma le viscosity.
Fa'amatalaga Lautele e uiga i le Hydroxypropyl Methylcellulose (HPMC)
Fa'atonuga Vailaau: O le HPMC e faia e ala i le fa'avasegaina o le cellulose e ala i le suitulaga o vaega hydroxyl (-OH) i vaega hydroxypropyl ma methyl. O le suitulaga e suia ai meatotino o le cellulose, e sili atu ona solu i totonu o le vai ma tuʻuina atu i ai ona uiga faʻapitoa e pei o le faʻaleleia atili o le gaosiga o ata, gafatia mafai, ma le gafatia e taofi le susu.
Fa'ailoa masani ma Fa'aigoaina
O le fa'ailoaina o le Hydroxypropyl Methylcellulose e masani ona fa'alagolago i le tele o igoa fa'aigoa o lo'o fa'amatalaina ai lona fausaga fa'ama'i ma meatotino:
Numera CAS:
E tu'uina atu e le Chemical Abstracts Service (CAS) se fa'amatalaga tulaga ese i vaila'au uma. Ole numera CAS mo Hydroxypropyl Methylcellulose ole 9004-65-3. Ole numera fa'ata'atia lea o lo'o fa'aogaina e foma'i kemisi, fa'atau oloa, ma fa'alāpotopotoga fa'atonutonu e fa'asino ile vaila'au.
InChI ma SMILES Codes:
InChI (International Chemical Identifier) ose isi auala e fa'atusaina ai le fausaga o vaila'au. O le HPMC o le a iai se manoa InChI umi e faʻatusalia lona fausaga mole i se faatulagaga faʻapitoa.
SMILES (Simplified Molecular Input Line Entry System) o se isi faiga e faʻaaogaina e faʻatusa ai molelaʻau i se tusitusiga. E iai fo'i le fa'ailoga SMILES a le HPMC, e ui ina fa'alavelave ona o le tele ma le fesuisuia'i o lona fausaga.
Fa'amatalaga o oloa:
I le maketi faapisinisi, HPMC e masani ona iloa i numera o oloa, lea e mafai ona fesuisuiai e le gaosiga. Mo se fa'ata'ita'iga, atonu e iai se togi e pei o le HPMC K4M po'o le HPMC E15. O nei faʻamatalaga e masani ona faasino i le viscosity o le polymer i le vaifofo, lea e fuafua i le tikeri o le methylation ma le hydroxypropylation faʻapea foʻi ma le mamafa mole.
Vasega masani o le Hydroxypropyl Methylcellulose (HPMC)
O uiga o le Hydroxypropyl Methylcellulose e eseese e faʻavae i luga o le tikeri o le sui o le methyl ma le hydroxypropyl vaega, faʻapea foʻi ma le mamafa mole. O nei fesuiaiga e iloa ai le viscosity o le HPMC ma le soluble i le vai, lea e afaina ai ana faʻaoga i pisinisi eseese.
O lo'o i lalo se laulau o lo'o fa'amatalaina ai togi eseese o le Hydroxypropyl Methylcellulose:
| Vasega | Viscosity (cP ile 2% solution) | Talosaga | Fa'amatalaga |
| HPMC K4M | 4000 – 6000 cP | Fa'amau fa'amau fa'ama'i, fale gaosi mea'ai, faufale (fa'apipi'i) | Vasega viscosity feololo, e masani ona fa'aogaina i fa'atutuga o laulau laulau. |
| HPMC K100M | 100,000 – 150,000 cP | Fa'atonu-fa'asa'oloto fa'asologa i vaila'au, faufale, ma vali vali | Ole maualuga ole viscosity, lelei tele mo le fa'asa'olotoina o vaila'au. |
| HPMC E4M | 3000 – 4500 cP | Mea teuteu, faletaele, gaosiga o mea'ai, fa'apipi'i, ma fa'alavalava | Solu i le vai malulu, fa'aaogaina i mea tau tausiga ma mea'ai. |
| HPMC E15 | 15,000 cP | Su'i fa'afefete i vali, pa'u, mea'ai, ma vaila'au | Ole maualuga ole viscosity, solu i le vai malulu, faʻaaogaina i fale gaosi oloa ma vailaʻau. |
| HPMC M4C | 4000 – 6000 cP | Alamanuia mea'ai ma meainu e fai ma fa'amautu, vaila'au fa'amasani e fa'apipi'i | Ole viscosity feololo, e masani ona fa'aogaina e fai ma mafiafia i mea'ai gaosi. |
| HPMC 2910 | 3000 – 6000 cP | Mea teuteu (kulimi, kulimi), mea'ai (mea suamalie), vaila'au (capsules, coatings) | O se tasi o togi sili ona taatele, faʻaaogaina e avea o se mea faʻamautu ma faʻafefete. |
| HPMC 2208 | 5000 – 15000 cP | Faʻaaogaina i sima ma sima faʻapipiʻi, ie, pepa faʻapipiʻi | Lelei mo fa'aoga e mana'omia ai mea lelei e fai ata tifaga. |
Fa'amatalaga Auiliiliga ma Meatotino a le HPMC
O mea fa'aletino o le Hydroxypropyl Methylcellulose e fa'alagolago tele i le tele o le suia o vaega hydroxyl i le mole mole cellulose. O mea tetele nei:
Tulaga o Suiga (DS):
E faasino lea i le tele o vaega o le hydroxyl i le cellulose ua suia e le methyl poo le hydroxypropyl vaega. O le maualuga o le suitulaga e a'afia ai le soluble ole HPMC ile vai, lona viscosity, ma lona malosi e fai ai ata. O le DS masani mo HPMC e mai le 1.4 i le 2.2, faʻatatau i le vasega.
Viscosity:
O togi HPMC e fa'avasegaina e fa'atatau i lo latou viscosity pe a fa'amavae i le vai. O le maualuga o le mamafa mole mole ma le tikeri o le suitulaga, o le maualuga o le viscosity. Mo se fa'ata'ita'iga, HPMC K100M (fa'atasi ai ma le maualuga o le viscosity range) e masani ona fa'aogaina i fa'atonuga fa'asa'olotoga o vaila'au, a'o togi la'ititi e pei o le HPMC K4M e masani ona fa'aoga mo mea fa'apipi'i papa ma mea'ai.
Suavai Solubility:
E solu le HPMC i le vai ma fai se mea e pei o se gel pe a fa'amavae, ae o le vevela ma le pH e mafai ona fa'aaafia ai lona solubility. Mo se faʻataʻitaʻiga, i totonu o le vai malulu, e vave faʻamavae, ae o lona solubility e mafai ona faʻaititia i le vai vevela, aemaise lava ile maualuga maualuga.
Malosiaga e fai ata tifaga:
O se tasi o vaega taua o le Hydroxypropyl Methylcellulose o lona gafatia e fausia ai se ata tifaga fetuutuunai. O lenei meatotino e talafeagai mo le faʻaogaina i totonu o laupepa papa, lea e maua ai se lamolemole, faʻasaʻo faʻasaʻo luga. E aoga fo'i ile fale gaosi mea'ai e fa'aleleia atili ai le tino ma le fa'aola.
Gelation:
I nisi faʻatonuga ma vevela, e mafai e le HPMC ona fai ni gels. O lenei meatotino e aoga i vailaʻau faʻamaʻi, lea e faʻaaogaina e fatu ai faiga faʻasaʻo-pulea.
Fa'aaogāga ole Hydroxypropyl Methylcellulose
Alamanuia tau vailaau:
O lo'o fa'aaogaina le HPMC e fai ma mea fa'apipi'i i fuala'au papa, aemaise i faiga fa'alaua'itele ma fa'asa'oloto. E galue foi o se sui faʻapipiʻi mo papa ma capsules e pulea ai le tuʻuina atu o le mea aoga. O lona gafatia e fausia ai ata mautu ma gels e lelei mo faiga faʻatau fualaau.
Alamanuia Taumafa
I le alamanuia o mea'ai, o le HPMC o lo'o fa'aaogaina e fai ma sui mafiafia, emulsifier, ma fa'amautu i le tele o oloa, e aofia ai sosi, la'ei, ma mea tao tao. E fesoasoani i le fa'aleleia atili o le tino ma fa'alautele le ola e ala i le fa'aitiitia o le susu.
Mea teuteu ma Tausiga a le Tagata Lava Ia:
O le HPMC e masani ona faʻaaogaina i mea teuteu, lea e galue e pei o se mafiafia ma faʻamautu i kulimi, lotions, shampoos, ma isi mea tau tausiga a le tagata lava ia. O lona gafatia e fausia ai se fausaga gel e sili ona aoga i nei talosaga.
Alamanuia Faufale:
I totonu o fale faufale, aemaise lava i sima ma sima faʻapipiʻi, o loʻo faʻaaogaina le HPMC e avea o se mea e teu ai vai. E fesoasoani i le fa'aleleia atili o galuega ma fa'aleleia atili le fa'aogaina o meafaitino.
Isi Talosaga:
O lo'o fa'afaigaluegaina fo'i le HPMC i fale 'ie, fa'alava pepa, ma e o'o fo'i i le gaosiga o ata e mafai ona pala.
Hydroxypropyl Methylcellulose (HPMC)ose fa'aoga sili ona lelei e fa'aogaina i le tele o alamanuia ona o ona uiga fa'apitoa e pei o le mafai ona fa'asolo ata, mafai fa'amalo, ma le taofiofia o le vai. E ui e leai se "numera fa'asologa" i le uiga masani, e fa'ailoaina e fa'amatalaga fa'amalama e pei o lona numera CAS (9004-65-3) ma togi fa'apitoa (eg, HPMC K100M, HPMC E4M). O le 'ese'ese o togi HPMC o lo'o avanoa e fa'amautinoa ai lona fa'aogaina i vaega eseese, mai vaila'au i mea'ai, mea teuteu, ma faufale.
Taimi meli: Mati-21-2025