Hydroxypropyl methylcellulose ikorwa n'iki?

Hydroxypropyl methylcellulose (HPMC) ni polymer ikoreshwa mu buryo bwinshi kandi ikoreshwa cyane mu nganda zitandukanye, izwiho imiterere yayo yihariye n'ikoreshwa ryayo. Iyi mvange ni ikomoka kuri cellulose, polymer karemano iboneka mu nkuta z'uturemangingo tw'ibimera. Kugira ngo dusobanukirwe imiterere ya hydroxypropylmethylcellulose, ni ngombwa gusesengura imiterere n'imikorere y'iyi cellulose ikomokaho.

Imiterere ya selulose:

Selulose ni karubohidrati igizwe n'uruhererekane rw'ibice bya β-D-glucose bihujwe n'imigozi ya β-1,4-glycosidic. Iyi migozi ya glucose ifatwa hamwe n'imigozi ya hydrogen kugira ngo ikore imiterere ikomeye. Selulose ni yo gice cy'ingenzi cy'inkuta z'uturemangingo tw'ibimera, igatanga imbaraga n'ubudahangarwa ku turemangingo tw'ibimera.

Ibikomoka kuri Hydroxypropyl Methylcellulose:

Hydroxypropyl methylcellulose ikorwa binyuze mu guhindura cellulose hakoreshejwe imiti no gushyira hydroxypropyl na methyl mu ruhererekane rw'ingenzi rwa cellulose. Ubusanzwe umusaruro ukubiyemo intambwe zikurikira:

Uburyo bwo guhindura eteri:

Methylation: Gutera selulose umuti wa alkaline na methyl chloride kugira ngo winjize amatsinda ya methyl (-CH3) mu matsinda ya hydroxyl (-OH) ya selulose.

Hydroxypropylation: Selulosi ya methylated irushaho gukorana na propylene oxide kugira ngo yinjize amatsinda ya hydroxypropyl (-CH2CHOHCH3) mu miterere ya selulosi. Iyi gahunda yongera ubushobozi bwo gushonga kw'amazi no guhindura imiterere ya selulosi.

gutunganya:

Hanyuma selulose yahinduwe isukurwa kugira ngo ikureho ibintu byose bitarakozweho, ibyavuye mu bimera cyangwa imyanda.

Kumisha no gusya:

Hydroxypropyl methylcellulose isukuye irayumishwa ikayisya ikayihindura ifu nziza yiteguye gukoreshwa mu buryo butandukanye.

Ibikoresho bya Hydroxypropyl Methylcellulose:

Imiterere ya hydroxypropyl methylcellulose irangwa n'urwego rwo gusimbuza, bivuze urwego hydroxypropyl na methyl groups zisimbura hydroxyl groups mu ruhererekane rwa cellulose. Ibyiciro bitandukanye bya HPMC bifite urwego rutandukanye rwo gusimbuza, bigira ingaruka ku gushonga kwabyo, ubukana n'ibindi bintu.

Formule y'ibinyabutabire ya hydroxypropyl methylcellulose ishobora kugaragazwa nka (C6H7O2(OH)3-mn(OCH3)m(OCH2CH(OH)CH3)n)_x, aho m na n bagaragaza urugero rw'isimbuza.

m: urugero rwa methylation (amatsinda ya methyl kuri buri gice cya glucose)

n: urugero rwa hydroxypropylation (amatsinda ya hydroxypropyl kuri buri gice cya glucose)

x: umubare w'ibice bya glucose mu ruhererekane rwa selulose

Ibiranga na Porogaramu:

Gushonga: HPMC irashonga mu mazi, kandi urwego rwo kuyihindura rugira ingaruka ku miterere yayo yo gushonga. Ikora umuti usobanutse kandi urimo kugorama mu mazi, bigatuma ikoreshwa mu buryo butandukanye.

Ubucucike: Ubucucike bw'umuti wa HPMC buterwa n'ibintu nk'uburemere bwa molekile n'urwego rwo gusimbuza. Iyi miterere ni ingenzi ku ikoreshwa nk'imiti ikenera imiti igenzurwa.

Imiterere ya firime: HPMC ishobora gukora uduce duto duto uko umuti wuma, bigatuma igira akamaro mu gusiga irangi mu nganda zikora imiti, ibiribwa n'izindi nganda.

Ibikoresho Bidahinduka n'Ibikomeza Ubushyuhe: Mu nganda z'ibiribwa, HPMC ikoreshwa nk'ikomeza ubushyuhe n'ibikomeza ubushyuhe mu bicuruzwa bitandukanye, birimo isosi, deseri, n'ibiryo bitetse.

Imikoreshereze y'imiti: HPMC ikoreshwa cyane mu miti, harimo ibinini, capsules, n'ibisubizo by'amaso, bitewe n'ubushobozi bwayo bwo kurekura no guhuza imiti n'ibindi bintu.

Ubwubatsi n'amabara: HPMC ikoreshwa mu bikoresho by'ubwubatsi nka mortiers, tile kole na plasters. Ikoreshwa kandi nk'ingufu zo gukurura no gushimangira mu irangi no mu mabara.

Ibikoresho byo kwisiga: Mu nganda zikora ibijyanye no kwisiga no kwita ku mubiri, HPMC iboneka mu bicuruzwa nka amavuta yo kwisiga, amavuta yo kwisiga n'amashampu, aho itanga imiterere n'ubudahangarwa.

Hydroxypropyl methylcellulose iboneka binyuze muri methylation na hydroxypropylation ya cellulose. Ni polymer ikoreshwa mu bintu byinshi kandi ikoreshwa mu buryo butandukanye. Imiterere yayo yihariye ituma igira agaciro mu nganda nko mu by'imiti, mu biribwa, mu bwubatsi no mu kwita ku buzima bwite. Guhindura cellulose mu buryo bugenzurwa bishobora kunoza imiterere ya HPMC, bigatuma iba igice cy'ingenzi cy'ibicuruzwa byinshi duhura nabyo mu buzima bwacu bwa buri munsi.