Hydroxypropyl methylcellulose (HPMC)ni selile idafite ionic selile ikoreshwa cyane mubikoresho byubaka, ubuvuzi, ibiryo, amavuta yo kwisiga nizindi nganda. Ifite ibintu byinshi byiza bifatika, bituma ikora neza mubikorwa bitandukanye.
1. Kugaragara no kwikemurira ibibazo
Ubusanzwe HPMC ni ifu yera cyangwa idafite umweru, impumuro nziza, uburyohe kandi ntabwo ari uburozi. Irashobora gushonga mumazi akonje hamwe na solge zimwe na zimwe (nkumuti uvanze nka Ethanol / amazi na acetone / amazi), ariko ntigishobora gushonga muri Ethanol yera, ether na chloroform. Bitewe na kamere yayo itari ionic, ntabwo izagira reaction ya electrolytique mugisubizo cyamazi kandi ntabwo izagerwaho cyane nagaciro ka pH.
2. Viscosity and rheology
HPMC igisubizo cyamazi gifite umubyimba mwiza na thixotropy. Ubwoko butandukanye bwa AnxinCel®HPMC bufite viscosities zitandukanye, kandi urwego rusanzwe ni mPa · s 5 kugeza 100000 (igisubizo cyamazi 2%, 20 ° C). Igisubizo cyacyo cyerekana pseudoplastique, ni ukuvuga kogosha ibintu, kandi birakwiriye gukoreshwa muburyo bukoreshwa nka coatings, slurries, adhesives, nibindi bisaba imvugo nziza.
3. Gutanga ubushyuhe
Iyo HPMC ishyutswe mumazi, transparency yumuti iragabanuka na gel ikorwa mubushyuhe runaka. Nyuma yo gukonja, leta ya gel izasubira mubisubizo. Ubwoko butandukanye bwa HPMC bufite ubushyuhe bwa gel butandukanye, muri rusange hagati ya 50 na 75 ° C. Uyu mutungo ni ingenzi cyane mubikorwa nko kubaka minisiteri na capsules ya farumasi.
4. Igikorwa cyo hejuru
Kuberako molekile ya HPMC irimo hydrophilique na hydrophobique matsinda, berekana ibikorwa bimwe na bimwe byo hejuru kandi birashobora kugira uruhare runini, gutatanya no gutuza. Kurugero, muri coatings na emulisiyo, HPMC irashobora kunoza ituze rya emulsiyo kandi ikarinda kwangirika kwingirangingo.
5. Hygroscopicity
HPMC ifite hygroscopique runaka kandi irashobora gukurura ubushuhe mubidukikije. Kubwibyo, mubisabwa bimwe, hagomba kwitonderwa kashe yo gupakira kugirango wirinde kwinjiza amazi no guhunika.
6. Umutungo wo gukora firime
HPMC irashobora gukora firime itoroshye kandi iboneye, ikoreshwa cyane mubiribwa, ubuvuzi (nkibikoresho byo gutwikira) hamwe no gutwikira. Kurugero, muruganda rwa farumasi, firime ya HPMC irashobora gukoreshwa nkigisate kibisi kugirango bitezimbere ibiyobyabwenge no kugenzura irekurwa.
7. Biocompatibilité n'umutekano
HPMC ntabwo ari uburozi kandi ntacyo itwaye, kandi irashobora guhindurwa neza numubiri wumuntu, bityo ikoreshwa cyane mubijyanye nubuvuzi nibiribwa. Nkibikoresho bya farumasi, mubisanzwe bikoreshwa mugukora ibinini bisohora-birekuye, capsule shell, nibindi.
8. pH ituze ryumuti
HPMC ihagaze neza muri pH iri hagati ya 3 na 11, kandi ntabwo yangirika byoroshye cyangwa ngo igwe na aside na alkali, bityo irashobora gukoreshwa muburyo butandukanye bwimiti, nkibikoresho byubaka, ibikomoka kumiti ya buri munsi nubuvuzi bwa farumasi.
9. Kurwanya umunyu
Umuti wa HPMC urahagaze neza ku myunyu ngugu kandi ntabwo igwa byoroshye cyangwa ntigire icyo ikora bitewe nimpinduka ziterwa na ion, ibyo bigatuma ishobora gukomeza gukora neza muri sisitemu zimwe zirimo umunyu (nka sima ya sima).
10. Guhagarara neza
AnxinCel®HPMC ifite ituze ryiza mubushyuhe bwo hejuru, ariko irashobora gutesha agaciro cyangwa guhinduka ibara iyo ihuye nubushyuhe bwinshi mugihe kirekire. Irashobora gukomeza gukora neza murwego runaka rwubushyuhe (mubisanzwe munsi ya 200 ° C), kubwibyo rero birakwiriye gukoreshwa mubushyuhe bwo hejuru.
11. Imiti ihamye
HPMCbirasa neza kumucyo, okiside hamwe nimiti isanzwe, kandi ntabwo byoroshye ingaruka ziterwa nubumara bwo hanze. Kubwibyo, irashobora gukoreshwa mubicuruzwa bisaba kubika igihe kirekire, nkibikoresho byo kubaka n'imiti.
Hydroxypropyl methylcellulose ikoreshwa cyane mu nganda nyinshi bitewe no gukomera kwayo, kubyimbye, kuzunguruka ubushyuhe, imiterere ya firime no gutuza imiti. Mu nganda zubaka, irashobora gukoreshwa nkububiko bwa sima; mu nganda zimiti, irashobora gukoreshwa nkibikoresho bya farumasi; mu nganda zibiribwa, ni inyongeramusaruro isanzwe. Nibintu byihariye byumubiri bituma HPMC yibikoresho byingenzi bya polymer.
Igihe cyo kohereza: Gashyantare-10-2025