HEC (Hydroxyethyl Cellulose)ni amazi asanzwe ashonga polymer akoreshwa cyane mugutegura imiti. Nibikomoka kuri selile, byabonetse mugukora Ethanolamine (okiside ya Ethylene) hamwe na selile. Bitewe no gukemuka kwiza, gutuza, ubushobozi bwo guhindura ibishishwa hamwe na biocompatibilité, HEC ifite uburyo bwinshi bwo gukoresha mubijyanye na farumasi, cyane cyane mugutezimbere, gushiraho imiterere ya dosiye no kugenzura ibiyobyabwenge.
1. Ibintu shingiro bya HEC
HEC, nka selile yahinduwe, ifite ibintu byibanze bikurikira:
Amazi meza: AnxinCel®HEC irashobora gukora igisubizo kiboneka mumazi, kandi gukomera kwayo bijyanye nubushyuhe na pH. Uyu mutungo utuma ukoreshwa muburyo butandukanye bwa dosiye nkumunwa hamwe ningenzi.
Biocompatibilité: HEC ntabwo ari uburozi kandi ntibitera umubiri wumuntu kandi irahuza nibiyobyabwenge byinshi. Kubwibyo, ikoreshwa cyane muburyo bwa dosiye irambye-irekurwa hamwe nubuyobozi bwibanze bwibiyobyabwenge.
Guhindura ibishishwa: Ubukonje bwa HEC burashobora guhinduka muguhindura uburemere bwa molekuline cyangwa ubunini bwabyo, ibyo bikaba ari ingenzi cyane mukugenzura igipimo cy’ibiyobyabwenge cyangwa kuzamura ibiyobyabwenge.
2. Gukoresha HEC mugutegura imiti
Nkibintu byingenzi mugutegura imiti, HEC ifite imirimo myinshi. Ibikurikira nibice byingenzi byifashishwa mugutegura imiti.
2.1 Gusaba mu myiteguro yo mu kanwa
Mu buryo bwa dosiye yo mu kanwa, HEC ikoreshwa kenshi mugukora ibinini, capsules hamwe nogutegura amazi. Ibikorwa byayo byingenzi birimo:
Binder: Mubinini na granules, HEC irashobora gukoreshwa nkumuhuza kugirango uhuze neza uduce duto twibiyobyabwenge cyangwa ifu hamwe kugirango tumenye ubukana nibihamye byibinini.
Igenzura rirambye: HEC irashobora kugera ku ngaruka ihoraho yo kurekura igenzura igipimo cy’ibiyobyabwenge. Iyo HEC ikoreshejwe hamwe nibindi bikoresho (nka polyvinyl pyrrolidone, carboxymethyl selulose, nibindi), irashobora kongera igihe kinini cyo gusohora imiti mumubiri, kugabanya inshuro zimiti, no kunoza kubahiriza abarwayi.
Thickener: Mu myiteguro yo mu kanwa, AnxinCel®HEC nkibyimbye irashobora kunoza uburyohe bwibiyobyabwenge hamwe nuburyo bwa dosiye.
2.2 Gushyira mubikorwa byateguwe
HEC ikoreshwa cyane mumavuta yibanze, amavuta, geles, amavuta yo kwisiga hamwe nindi myiteguro, ikina inshingano nyinshi:
Gel matrix: HEC ikoreshwa nka matrix ya geles, cyane cyane muri sisitemu yo gutanga imiti ya transdermal. Irashobora gutanga ubudahwema bukwiye kandi ikongerera igihe cyo gutura imiti kuruhu, bityo ikanoza imikorere.
Viscosity and stabilite: Ubukonje bwa HEC burashobora kongera guhuza imyiteguro yibanze kuruhu kandi bikarinda ibiyobyabwenge kugwa imburagihe bitewe nimpamvu zituruka hanze nko guterana cyangwa gukaraba. Byongeye kandi, HEC irashobora kunoza ituze ryamavuta namavuta kandi ikarinda gutondeka cyangwa korohereza.
Lubricant and moisturizer: HEC ifite imiterere myiza yubushuhe kandi irashobora gufasha kugumya uruhu no kwirinda gukama, bityo ikoreshwa no mubushuhe nibindi bicuruzwa byita kuruhu.
2.3 Gushyira mubikorwa byamaso
Gushyira mu bikorwa HEC mu myiteguro y’amaso bigaragarira cyane cyane mu nshingano zayo zifata kandi zisiga amavuta:
Indwara ya Ophthalmic hamwe nigitonyanga cyamaso: HEC irashobora gukoreshwa nkumuti wogutegura amaso kugirango wongere igihe cyo guhura hagati yibiyobyabwenge nijisho kandi bikomeza imikorere yibiyobyabwenge. Muri icyo gihe, ububobere bwacyo burashobora kandi kubuza ko ijisho ritakaza vuba kandi bikongera igihe cyo gufata ibiyobyabwenge.
Amavuta: HEC ifite hydrated nziza kandi irashobora gutanga amavuta ahoraho mukuvura indwara zamaso nkamaso yumye, bikagabanya kubura amaso.
2.4 Gusaba mugutegura inshinge
HEC irashobora kandi gukoreshwa mugutegura impapuro zatewe inshinge, cyane cyane mugutera inshinge ndende no gutegura-kurekura. Ibikorwa by'ingenzi bya HEC muri iyi myiteguro harimo:
Thickener na stabilisateur: Mu gutera inshinge,HECirashobora kongera ubwiza bwumuti, kugabanya umuvuduko wo gutera inshinge, no kongera umutekano wibiyobyabwenge.
Kugenzura irekurwa ry'ibiyobyabwenge: Nka kimwe mu bigize sisitemu ikomeza kurekura ibiyobyabwenge, HEC irashobora kugenzura igipimo cyo kurekura imiti ikora geli nyuma yo guterwa inshinge, kugirango igere ku ntego yo kuvura igihe kirekire.
3. Uruhare rwa HEC muri sisitemu yo gutanga ibiyobyabwenge
Hamwe n’iterambere ry’ikoranabuhanga mu bya farumasi, HEC yakoreshejwe cyane muri sisitemu zitandukanye zo gutanga ibiyobyabwenge, cyane cyane mu bijyanye n’abatwara ibiyobyabwenge nano, microsperes, hamwe n’ibiyobyabwenge bikomeza kurekura. HEC irashobora guhuzwa nibikoresho bitandukanye bitwara ibiyobyabwenge kugirango bibe urwego ruhamye kugirango irekure kandi itangwe neza.
Abatwara ibiyobyabwenge bya Nano: HEC irashobora gukoreshwa nka stabilisateur kubatwara ibiyobyabwenge bya nano kugirango birinde kwegeranya cyangwa kugwa kwinshi kwabatwara no kongera bioavailable yibiyobyabwenge.
Microsperes nuduce: HEC irashobora gukoreshwa mugutegura microsperes hamwe nabatwara ibiyobyabwenge bya microparticle kugirango ibiyobyabwenge bisohore buhoro mumubiri no kunoza imikorere yibiyobyabwenge.
Nka farumasi ikora kandi ikora neza, AnxinCel®HEC ifite amahirwe menshi yo gukoresha mugutegura imiti. Hamwe n’iterambere rikomeje ry’ikoranabuhanga mu bya farumasi, HEC igira uruhare runini mu kugenzura irekurwa ry’ibiyobyabwenge, ubuyobozi bw’ibanze, imyiteguro irekura-uburyo bushya bwo gutanga imiti. Nibyiza biocompatibilité, guhindagurika kwijimye no gutuza bituma bidasimburwa mubijyanye nubuvuzi. Mu bihe biri imbere, hamwe n’ubushakashatsi bwimbitse bwa HEC, ikoreshwa ryayo mu miti ya farumasi rizaba ryinshi kandi ritandukanye.
Igihe cyo kohereza: Ukuboza-28-2024