HPMC irashobora gushonga mumazi ashyushye?

HPMC (Hydroxypropyl Methylcellulose)ni polimeri itari ionic igice cya sintetike ikoreshwa cyane mubuvuzi, ibiryo, ubwubatsi, impuzu nizindi nganda. Ku bijyanye no kumenya niba HPMC ishobora gushonga mu mazi ashyushye, ibiranga ubukana bwayo n'ingaruka z'ubushyuhe ku myitwarire yayo.

Incamake yo gukemura HPMC

HPMC ifite amazi meza, ariko imyitwarire yo kuyasesa ifitanye isano nubushyuhe bwamazi. Mubisanzwe, HPMC irashobora gukwirakwira no gushonga mumazi akonje, ariko irerekana ibintu bitandukanye mumazi ashyushye. Ubushobozi bwa HPMC mumazi akonje bugira ingaruka cyane cyane kumiterere ya molekuline nubwoko bwimbaraga. Iyo HPMC ihuye n’amazi, amatsinda ya hydrophilique (nka hydroxyl na hydroxypropyl) muri molekile zayo azakora imigozi ya hydrogène hamwe na molekile y’amazi, bigatuma buhoro buhoro ikabyimba. Nyamara, ibisubizo biranga HPMC biratandukanye mumazi mubushyuhe butandukanye.

Gukemura HPMC mumazi ashyushye

Ubushobozi bwa HPMC mumazi ashyushye biterwa nubushyuhe:

Ubushyuhe buke (0-40 ° C): HPMC irashobora kwinjiza buhoro buhoro amazi ikabyimba, amaherezo igakora igisubizo kibonerana cyangwa cyoroshye. Igipimo cyo gusesa kiratinda kubushyuhe buke, ariko gelation ntabwo ibaho.

Ubushyuhe bwo hagati (40-60 ° C): HPMC irabyimba muri ubu bushyuhe, ariko ntishonga rwose. Ahubwo, byoroshye gukora agglomerates itaringaniye cyangwa guhagarikwa, bigira ingaruka kumuti umwe.

Ubushyuhe bwo hejuru (hejuru ya 60 ° C): HPMC izatandukana nicyiciro cyubushyuhe bwo hejuru, bigaragazwa nkimvura cyangwa imvura, bikagorana gushonga. Muri rusange, iyo ubushyuhe bwamazi burenze 60-70 ° C, umuvuduko wubushyuhe bwurunigi rwa molekile ya HPMC urakomera, kandi gukomera kwayo kugabanuka, kandi amaherezo bishobora gukora gel cyangwa imvura.

Imiterere ya Thermogel ya HPMC

HPMC ifite imiterere isanzwe ya thermogel, ni ukuvuga ko ikora gel mubushyuhe bwo hejuru kandi irashobora gukemurwa nubushyuhe buke. Uyu mutungo ni ingenzi cyane mubisabwa byinshi, nka:

Inganda zubaka: HPMC ikoreshwa nkibibyimbye bya sima. Irashobora kugumana ubuhehere bwiza mugihe cyubwubatsi kandi ikagaragaza imiterere yubushyuhe bwo hejuru kugirango igabanye amazi.

Imyiteguro ya farumasi: Iyo ikoreshejwe nk'ibikoresho byo gutwikira mu bisate, imiterere yacyo ya gelasiyo igomba gutekerezwa kugirango ibashe gukemuka neza.

Inganda zibiribwa: HPMC ikoreshwa nkibyimbye na emulisiferi mubiribwa bimwe na bimwe, kandi ubushyuhe bwayo bwumuriro bufasha gutunga ibiryo.

Nigute ushobora gusesa HPMC neza?

Mu rwego rwo kwirinda HPMC gukora gel mu mazi ashyushye no kunanirwa gushonga, uburyo bukurikira bukoreshwa:

Uburyo bwo gukwirakwiza amazi akonje:

Ubwa mbere, kuringaniza HPMC mumazi akonje cyangwa amazi yubushyuhe bwicyumba kugirango utose kandi ubyimbye.

Buhoro buhoro uzamura ubushyuhe mugihe cyo gukurura HPMC.

Nyuma yo gushonga burundu, ubushyuhe burashobora kwiyongera muburyo bukwiye kugirango byihuse igisubizo.

Uburyo bukonje bwo gukwirakwiza amazi ashyushye:

Ubwa mbere, koresha amazi ashyushye (hafi 80-90 ° C) kugirango ukwirakwize vuba HPMC kugirango habeho urwego rwo gukingira gel rudashobora gushonga hejuru yacyo kugirango wirinde guhita habaho ibibyimba bifatanye.

Nyuma yo gukonjesha ubushyuhe bwicyumba cyangwa kongeramo amazi akonje, HPMC irashonga buhoro buhoro kugirango ikore igisubizo kimwe.

Uburyo bwo kuvanga bwumye:

Kuvanga HPMC nibindi bintu bishonga (nk'isukari, krahisi, mannitol, nibindi) hanyuma wongeremo amazi kugirango ugabanye agglomeration kandi uteze imbere gusesekara kimwe.

HPMCntishobora gushonga mumazi ashyushye. Biroroshye gukora gel cyangwa kugwa mubushyuhe bwinshi, bigabanya gukomera kwayo. Uburyo bwiza bwo gusesa ni ugukwirakwiza amazi akonje mbere cyangwa kubanza gutatanya amazi ashyushye hanyuma ugakonja kugirango ubone igisubizo kimwe kandi gihamye. Mubikorwa bifatika, hitamo uburyo bukwiye bwo gusesa ukurikije ibikenewe kugirango HPMC ikore neza.