Kodi chinyezi cha HPMC ndi chiyani?

Hydroxypropyl Methylcellulose (HPMC)ndi polima wosungunuka m'madzi womwe umagwiritsidwa ntchito kwambiri m'mafakitale opanga mankhwala, chakudya, zodzola, ndi zomangamanga. Chinyezi cha HPMC chimagwira ntchito yofunika kwambiri pakukonza ndi kukhazikika kwake. Zimakhudza rheological katundu, solubility, ndi alumali moyo wa zinthu. Kumvetsetsa chinyezi ndikofunikira pakupanga kwake, kusungirako, komanso kugwiritsa ntchito komaliza.

Chinyezi cha HPMC

Chinyezi cha AnxinCel®HPMC nthawi zambiri chimatsimikiziridwa ndi momwe zimagwirira ntchito komanso mtundu wake wa polima wogwiritsidwa ntchito. Chinyezicho chimatha kusiyanasiyana malinga ndi zopangira, malo osungira, komanso kuyanika. Nthawi zambiri amawonetsedwa ngati kuchuluka kwa kulemera kwachitsanzo isanayambe kapena itatha kuyanika. Pazinthu zamafakitale, chinyezi chimakhala chofunikira, chifukwa chinyezi chambiri chingayambitse kuwonongeka, kugwa, kapena kuchepa kwa magwiridwe antchito a HPMC.

Chinyezi cha HPMC chikhoza kuchoka pa 5% kufika pa 12%, ngakhale kuti mtundu wake uli pakati pa 7% ndi 10%. Chinyezicho chikhoza kuzindikirika poyanika chitsanzo pa kutentha kwina (mwachitsanzo, 105 ° C) mpaka kufika kulemera kosalekeza. Kusiyana kwa kulemera musanayambe kuyanika kumayimira chinyezi.

Zomwe Zimakhudza Chinyezi mu HPMC

Zinthu zingapo zimatha kukhudza chinyezi cha HPMC:

Chinyezi ndi Zosungirako:

Chinyezi chapamwamba kapena malo osayenera osungira amatha kuwonjezera chinyezi cha HPMC.

HPMC ndi hygroscopic, kutanthauza kuti imakonda kuyamwa chinyezi kuchokera mumlengalenga wozungulira.

Kuyika ndi kusindikiza mankhwala kumachepetsa kuyamwa kwa chinyezi.

Zoyenera Kukonzekera:

Kutentha kwa kuyanika ndi nthawi yopangira zinthu kumatha kukhudza chinyezi chomaliza.

Kuyanika msanga kungayambitse chinyezi chotsalira, pamene kuyanika pang'onopang'ono kungapangitse kuti chinyezi chisungidwe.

Gawo la HPMC:

Mitundu yosiyanasiyana ya HPMC (mwachitsanzo, kukhuthala kotsika, kukhuthala kwapakati, kapena kukhuthala kwakukulu) ikhoza kukhala ndi chinyezi chosiyana pang'ono chifukwa cha kusiyana kwa mamolekyu ndi kachitidwe.

Zotsatsa Zotsatsa:

Othandizira atha kupatsa HPMC ndi chinyezi chodziwika chomwe chimagwirizana ndi miyezo yamakampani.

Chinyezi Chodziwika cha HPMC potengera Giredi

Chinyezi cha HPMC chimasiyana malinga ndi giredi ndi ntchito yomwe mukufuna. Nayi tebulo lomwe likuwonetsa kuchuluka kwa chinyezi m'makalasi osiyanasiyana a HPMC.

Kuyesa ndi Kutsimikiza kwa Chinyezi

Pali njira zingapo zodziwira chinyezi cha HPMC. Njira ziwiri zodziwika bwino ndi izi:

Njira ya Gravimetric (Kutayika pa Kuyanika, LOD):

Iyi ndi njira yomwe imagwiritsidwa ntchito kwambiri pozindikira kuchuluka kwa chinyezi. Kulemera kodziwika kwa HPMC kumayikidwa mu uvuni woyanika pa 105 ° C. Pambuyo pa nthawi yodziwika (nthawi zambiri maola 2-4), chitsanzocho chimayesedwanso. Kusiyana kwa kulemera kumapereka chinyezi, chomwe chimawonetsedwa ngati chiwerengero cha kulemera kwachitsanzo choyambirira.

Karl Fischer Titration:

Njirayi ndi yolondola kuposa LOD ndipo imakhudzanso kachitidwe kakemiko komwe kamawerengera kuchuluka kwa madzi. Njirayi imagwiritsidwa ntchito nthawi zambiri pakafunika kudziwa chinyezi.

Zotsatira za Chinyezi pa Zida za HPMC

Chinyezi cha AnxinCel®HPMC chimakhudza magwiridwe antchito osiyanasiyana:

Viscosity:Chinyezicho chimatha kukhudza kukhuthala kwa mayankho a HPMC. Kuchuluka kwa chinyezi kungapangitse mamasukidwe akayendedwe ena, pomwe chinyezi chochepa chingapangitse kukhuthala kocheperako.

Kusungunuka:Kuchuluka kwa chinyezi kungayambitse kusakanikirana kapena kuchepetsa kusungunuka kwa HPMC m'madzi, kupangitsa kuti ikhale yocheperapo pazinthu zina, monga kumasulidwa koyendetsedwa mumakampani opanga mankhwala.

Kukhazikika:HPMC nthawi zambiri imakhala yokhazikika pakauma, koma kuchuluka kwa chinyezi kungayambitse kukula kwa tizilombo toyambitsa matenda kapena kuwonongeka kwa mankhwala. Pachifukwa ichi, HPMC nthawi zambiri imasungidwa m'mitsuko yosindikizidwa m'malo opanda chinyezi.

Chinyezi ndi Kupaka kwa HPMC

Chifukwa cha chikhalidwe cha hygroscopic cha HPMC, kuyika bwino ndikofunikira kuti tipewe kuyamwa kwa chinyezi kuchokera mumlengalenga. HPMC nthawi zambiri imayikidwa m'matumba oteteza chinyezi kapena zotengera zopangidwa ndi zinthu monga polyethylene kapena laminates zamitundu ingapo kuti ziteteze ku chinyezi. Kupakako kumatsimikizira kuti chinyezi chimakhalabe mkati momwe mukufunira panthawi yosungira ndi kuyendetsa.

Kuwongolera kwachinyezi pakupanga

Popanga HPMC, ndikofunikira kuyang'anira ndikuwongolera chinyezi kuti zinthu zisamayende bwino. Izi zitha kutheka kudzera:

Njira Zoyanika:HPMC ikhoza kuumitsidwa pogwiritsa ntchito mpweya wotentha, zowumitsa vacuum, kapena zowumitsa zozungulira. Kutentha ndi nthawi ya kuyanika ziyenera kukonzedwa bwino kuti zisamawumitse (kuchuluka kwa chinyezi) ndi kuumitsa mopitirira muyeso (zomwe zingayambitse kuwonongeka kwa kutentha).

Kuwongolera Zachilengedwe:Kusunga malo olamulidwa ndi chinyezi chochepa m'malo opangira ndizofunikira. Izi zingaphatikizepo zochepetsera chinyezi, zoziziritsira mpweya, ndi kugwiritsa ntchito masensa a chinyezi kuyang'anira momwe mlengalenga ukugwirira ntchito.

Chinyezi cha Mtengo wa HPMCnthawi zambiri zimagwera mkati mwa 7% mpaka 10%, ngakhale zimatha kusiyanasiyana kutengera giredi, kugwiritsa ntchito, ndi kusungirako. Chinyezi ndi gawo lofunikira lomwe limakhudza rheological properties, solubility, ndi kukhazikika kwa AnxinCel®HPMC. Opanga ndi opanga ma formula amayenera kuwongolera mosamala ndikuwunika momwe chinyezi chilili kuti awonetsetse kuti ntchito zawo zikuyenda bwino.