Kukonzekera kwa Hydroxypropyl Methylcellulose

Hydroxypropyl Methylcellulose (HPMC)ndi polima osungunuka m'madzi omwe amapezeka posintha mankhwala a cellulose. Amagwiritsidwa ntchito makamaka pazamankhwala, chakudya, zodzoladzola, ndi zomangamanga, ndipo ali ndi zinthu zabwino kwambiri monga kukhuthala, kupanga mafilimu, emulsification, ndi kukhazikika.

1. Mfundo yokonzekera

Hydroxypropyl methylcellulose ndi chochokera ku hydrophilic cellulose, ndipo kusungunuka kwake kumakhudzidwa makamaka ndi hydroxypropyl ndi methyl substituents mu molekyulu. Gulu la methyl limawonjezera kusungunuka kwake kwamadzi, pomwe gulu la hydroxypropyl limawonjezera kusungunuka kwake m'madzi. Nthawi zambiri, AnxinCel®HPMC imatha kusungunuka mwachangu m'madzi ozizira kuti ipange njira yofananira ya colloidal, koma imasungunuka pang'onopang'ono m'madzi otentha, ndipo zinthu zagranular zimatha kuphatikizika panthawi ya kusungunuka. Choncho, chidwi chiyenera kuperekedwa pakuwongolera kutentha kwa kutentha ndi kusungunuka panthawi yokonzekera.

2. Kukonzekera zakuthupi

HPMC ufa: Sankhani ufa wa HPMC wokhala ndi ma viscosities osiyanasiyana ndi madigiri olowa m'malo malinga ndi zofunikira zogwiritsira ntchito. Zitsanzo zodziwika bwino zimaphatikizapo kukhuthala kochepa (kuchepa kwa maselo) ndi kukhuthala kwakukulu (kulemera kwa maselo). Kusankhidwa kuyenera kutengera zosowa za kapangidwe kake.

Zosungunulira: Madzi ndi mankhwala omwe amagwiritsidwa ntchito kwambiri, makamaka popaka mankhwala ndi zakudya. Malingana ndi zofunikira zowonongeka, chisakanizo cha madzi ndi zosungunulira zamoyo, monga ethanol / madzi osakanikirana, angagwiritsidwenso ntchito.

3. Njira yokonzekera

Kulemera kwa HPMC
Choyamba, yesani molondola ufa wa HPMC wofunikira malinga ndi kuchuluka kwa yankho lokonzekera. Nthawi zambiri, ndende ya HPMC ndi 0.5% mpaka 10%, koma ndende yake iyenera kusinthidwa malinga ndi cholinga komanso kukhuthala kofunikira.

Kusungunula chisanadze
Pofuna kupewa HPMC ufa kuchokera ku agglomerating, kusungunula kusanayambe kulowetsedwa kumatengedwa. Ntchito yeniyeni ndi: kuwaza ufa wa HPMC wolemera mofanana mu gawo la zosungunulira, gwedezani pang'onopang'ono, ndi kupanga HPMC ufa kukhudzana ndi zosungunulira pang'ono poyamba kupanga dziko lonyowa. Izi zitha kulepheretsa ufa wa HPMC kuti usagwirizane ndikulimbikitsa kubalalitsidwa kwake yunifolomu.

Njira yothetsera
Pang'onopang'ono yonjezerani zosungunulira zotsalira ku ufa wonyowa wa HPMC ndikupitiriza kuyambitsa. Popeza HPMC ali bwino madzi solubility, madzi ndi HPMC kupasuka mwamsanga firiji. Pewani kugwiritsa ntchito mphamvu yometa ubweya wambiri poyambitsa, chifukwa kugwedezeka kwakukulu kumapangitsa kuti thovu lipangike, zomwe zimakhudza kuwonekera ndi kufanana kwa yankho. Nthawi zambiri, liwiro loyambitsanso liyenera kusungidwa pamtunda wocheperako kuti zitsimikizire kusungunuka kofanana.

Kuwongolera kutentha
Ngakhale HPMC ikhoza kusungunuka m'madzi ozizira, ngati kusungunuka kuli pang'onopang'ono, yankho likhoza kutenthedwa moyenera. Kutentha kwa kutentha kuyenera kuyendetsedwa pakati pa 40 ° C ndi 50 ° C kuti zisatenthe kwambiri zomwe zimayambitsa kusintha kwa maselo kapena kusintha kwakukulu kwa kukhuthala kwa yankho. Panthawi yotentha, kusonkhezera kuyenera kupitilira mpaka HPMC itasungunuka kwathunthu.

Kuziziritsa ndi kusefera
Pambuyo pa kusungunuka kwathunthu, lolani kuti yankho lizizizira mwachibadwa mpaka kutentha. Panthawi yoziziritsa, tinthu tating'onoting'ono tating'onoting'ono kapena zonyansa zitha kuwoneka mu yankho. Ngati ndi kotheka, fyuluta ingagwiritsidwe ntchito kusefa kuti ichotse tinthu tating'ono tolimba ndikuwonetsetsa kumveka bwino kwa yankho.

Kusintha komaliza ndi kusungirako
Njirayo itakhazikika, ndende yake imatha kusinthidwa malinga ndi zosowa zenizeni. Ngati ndendeyo ili yochulukirapo, chosungunulira chikhoza kuwonjezeredwa kuti chichepetse; ngati chiwerengerocho chili chochepa kwambiri, ufa wambiri wa HPMC uyenera kuwonjezeredwa. Njirayi ikatha kukonzedwa, iyenera kugwiritsidwa ntchito nthawi yomweyo. Ngati ikufunika kusungidwa kwa nthawi yayitali, iyenera kusungidwa mu chidebe chotsekedwa kuti madzi asasunthike kapena kuipitsidwa ndi yankho.

4. Njira zodzitetezera

Kuwongolera kutentha: Kutentha kwakukulu kuyenera kupewedwa panthawi ya kusungunuka kuti zisakhudze kusungunuka ndi ntchito ya AnxinCel®HPMC. Pa kutentha kwambiri, HPMC akhoza amanyoza kapena mamasukidwe akayendedwe ake akhoza kuchepa, okhudza ntchito zotsatira zake.

Njira yokondolera: Pewani kumeta mopambanitsa kapena kuthamanga kwambiri pakugwedeza, chifukwa kugwedezeka mwamphamvu kungayambitse thovu ndi kusokoneza kuwonekera kwa yankho.

Kusankha zosungunulira: Madzi ndi omwe amagwiritsidwa ntchito kwambiri, koma muzinthu zina zapadera, njira yosakanikirana yamadzi ndi zosungunulira zina (monga mowa, acetone, etc.) zikhoza kusankhidwa. Mitundu yosiyanasiyana ya zosungunulira idzakhudza kuchuluka kwa kusungunuka ndi ntchito ya yankho.

Kusungirako: Njira yokonzekera ya HPMC iyenera kusungidwa pamalo ozizira komanso owuma kuti asatengeke kwa nthawi yayitali kutentha kapena kuwala kwa dzuwa kuti asasinthe kusintha kwa yankho.

Anti-caking: Pamene ufa umawonjezeredwa ku zosungunulira, ngati ufawo wawonjezeredwa mofulumira kwambiri kapena wosagwirizana, zimakhala zosavuta kupanga zotupa, choncho ziyenera kuwonjezeredwa pang'onopang'ono.

5. Minda yofunsira

Hydroxypropyl methylcellulose imagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana chifukwa cha kusungunuka kwake bwino m'madzi komanso kuyanjana ndi biocompatibility:

Makampani opanga mankhwala: Monga filimu yakale, zomatira, zokhuthala, zotulutsa zokhazikika, ndi zina zotero za mankhwala, zimagwira ntchito yofunika kwambiri pokonzekera mankhwala.

Makampani azakudya: Monga thickener, emulsifier, stabilizer, nthawi zambiri amagwiritsidwa ntchito pokonza zakudya, monga ayisikilimu, zokometsera, zakumwa, ndi zina.

Makampani omanga: Monga chokhuthala cha zokutira zomanga ndi matope, imatha kupititsa patsogolo kumamatira ndi madzimadzi osakaniza.

Zodzoladzola: Monga chowonjezera, chokhazikika komanso choyambirira cha filimu, chimagwiritsidwa ntchito mu zodzoladzola monga mafuta opaka, ma shampoos, ndi mankhwala osamalira khungu kuti apititse patsogolo khalidwe lazogulitsa ndi luso la ogwiritsa ntchito.

Kukonzekera kwaMtengo wa HPMCndi njira yomwe imafuna chidwi chatsatanetsatane. Panthawi yokonzekera, zinthu monga kutentha, njira yogwedeza, ndi kusankha zosungunulira ziyenera kuyang'aniridwa kuti zitsimikizidwe kuti zitha kusungunuka ndi kusunga ntchito yabwino. Kupyolera mu njira yoyenera yokonzekera, AnxinCel®HPMC ikhoza kugwiritsidwa ntchito kwambiri m'mafakitale angapo ndikugwira ntchito yofunika kwambiri.