Makhalidwe aukadaulo wotentha kwambiri wa hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC)ndi chinthu chofunikira chamankhwala, chomwe chimagwiritsidwa ntchito kwambiri pomanga, mankhwala, chakudya ndi madera ena. Makamaka pamakampani omanga, HPMC imagwiritsidwa ntchito kwambiri chifukwa chakuchita bwino. Ukadaulo wa kutentha kwambiri umagwira ntchito yofunika kwambiri pakupanga ndi kugwiritsa ntchito HPMC.

1. Udindo wa teknoloji yotentha kwambiri mu HPMC

kupanga Hydroxypropyl methylcellulose imapezeka ndi machitidwe angapo amankhwala monga alkalization ndi etherification ya cellulose yachilengedwe. High kutentha luso zimagwiritsa ntchito kuvunda, kuyanika ndi akamaumba magawo anachita ndondomeko. Mkulu kutentha mankhwala sangakhoze imathandizira zimene mlingo, komanso kusintha chiyero ndi bata la mankhwala.

Kupititsa patsogolo anachita bwino

Pansi pa kutentha kwambiri, zomwe zimayendera pa cellulose ndi sodium hydroxide zimathamanga, zomwe zimalimbikitsa hydroxypropyl ndi methyl m'malo momwe zimachitikira mkati mwa mamolekyu a cellulose, potero kuwongolera kuchuluka kwa m'malo (DS) ndi kufanana kwa HPMC.

Chotsani zonyansa

Kutentha kwapamwamba kumatha kuchotsa bwino zinthu zopangidwa ndi zomwe zimapangidwira, monga njira yosasinthika ya alkali ndi zosungunulira, ndikuwongolera chiyero cha HPMC.

Kuwongolera kuyanika bwino

Panthawi yowumitsa kutentha kwambiri, chinyezi cha HPMC chimasanduka nthunzi msanga, kupeŵa mankhwalawo kuti asakhale agglomerating kapena denaturing pa kutentha kochepa, ndikuwongolera kukhazikika ndi kusungirako ntchito.

2. Zotsatira za teknoloji yotentha kwambiri pa ntchito ya HPMC

Ukadaulo wotentha kwambiri umangokhudza mawonekedwe akuthupi a HPMC, komanso umakhudza kwambiri zinthu zake zama mankhwala ndi zotsatira zake.

Kusintha kwa viscosity

The mkulu-kutentha ndondomeko akhoza bwino kulamulira maselo kulemera kugawa HPMC, potero kusintha mamasukidwe akayendedwe ake. Kutentha kwapamwamba kumathandizira kuchepetsa kuthekera kwa kusweka kwa maselo, kupangitsa kukhuthala kwa HPMC mu njira yamadzi yokhazikika.

Kuteteza kutentha

Kukhazikika kwa kutentha kwa HPMC kumakhala bwino kwambiri chifukwa cha chithandizo cha kutentha kwambiri. Pomanga zomatira zamatope ndi matailosi, HPMC imatha kukhalabe yomatira komanso anti-sagging katundu pansi pa kutentha kwambiri.

Kusungunuka kwabwino

Pa kutentha kwambiri kuyanika ndondomeko, ndi microstructure wa HPMC wokometsedwa, kupangitsa kuti sungunuka m'madzi ozizira. Makamaka m'malo omanga otsika kutentha, HPMC imatha kusungunuka mwachangu ndikupanga njira yofananira ya colloidal.

3. Kugwiritsa ntchito mwachindunji kwaukadaulo wa kutentha kwambiri munjira yopangira HPMC

Etherification reaction stage

Pochita etherification reaction pa kutentha kwakukulu kwa 80-100 ° C, kusintha kwa hydroxypropyl ndi magulu a methyl kumatha kufulumizitsidwa, kotero kuti HPMC ili ndi digiri yapamwamba yolowa m'malo komanso kukhazikika bwino.

Kuyanika ndi kuphwanya siteji

Ukadaulo wowumitsa mpweya wotentha pamwamba pa 120 ° C sungathe kungochotsa chinyezi, komanso umalepheretsa ufa wa HPMC kuti usakanike panthawi yowumitsa. Pambuyo pake, ukadaulo wapamwamba wophwanya kutentha umagwiritsidwa ntchito kupanga tinthu tating'ono ta HPMC kukhala osakhwima komanso yunifolomu, ndipo dispersibility ya mankhwalawa imakhala bwino.

Kutentha kwambiri kuchiritsa mankhwala

HPMC ikagwiritsidwa ntchito pomanga zomangira kapena zokutira, kutentha kwambiri kuchiritsa chithandizo kumatha kukulitsa kukana kwake ming'alu, kukana kwamadzi komanso kusunga madzi, ndikuwonetsetsa kuti zomangamanga zimakhala zabwino m'malo ovuta.

4. Ubwino waukadaulo wotentha kwambiri m'magawo ogwiritsira ntchito a HPMC

Zomangira

Pansi pa kutentha kwakukulu, HPMC imawonetsa kukhuthala bwino komanso kusunga madzi mumatope ndi ufa wa putty, kuteteza matope kuti asatuluke mwachangu komanso kusweka.

Makampani opanga utoto

HPMC yopangidwa ndi kutentha kwambiri imakhala ndi zowongolera bwino komanso zotsutsa-zotupa mu utoto wa latex, zomwe zimathandizira kumamatira komanso kukana kuvala kwa zokutira.

Makampani opanga mankhwala

Ukadaulo wotentha kwambiri ukhoza kupangitsa kuti HPMC ikhale yofananira pakupaka mankhwala ndikuwonetsetsa kuti kukhazikika kwamankhwala kumatulutsidwa.

Kugwiritsa ntchito luso lapamwamba la kutentha kwahydroxypropyl methylcellulosesikuti kumangowonjezera kupanga bwino, komanso kumawonjezera magwiridwe antchito azinthu. Kupyolera mu kutentha kwapamwamba, kukhuthala, kusungunuka ndi kukhazikika kwa kutentha kwa HPMC kwakonzedwa bwino, ndikupangitsa kuti ikhale ndi chiyembekezo chogwiritsa ntchito pomanga, zokutira ndi mankhwala. M'tsogolomu, ndi luso lopitirizabe la teknoloji yotentha kwambiri, ntchito ya HPMC idzapitirizidwa bwino, ndikuthandiza kwambiri pakupanga zipangizo zobiriwira komanso zachilengedwe.